ID C7ME51_BRAFD Unreviewed; 497 AA.
AC C7ME51;
DT 13-OCT-2009, integrated into UniProtKB/TrEMBL.
DT 13-OCT-2009, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN OrderedLocusNames=Bfae_20510 {ECO:0000313|EMBL:ACU85858.1};
OS Brachybacterium faecium (strain ATCC 43885 / DSM 4810 / JCM 11609 / LMG
OS 19847 / NBRC 14762 / NCIMB 9860 / 6-10).
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Dermabacteraceae;
OC Brachybacterium.
OX NCBI_TaxID=446465 {ECO:0000313|EMBL:ACU85858.1, ECO:0000313|Proteomes:UP000001919};
RN [1] {ECO:0000313|EMBL:ACU85858.1, ECO:0000313|Proteomes:UP000001919}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 43885 / DSM 4810 / JCM 11609 / LMG 19847 / NBRC 14762 /
RC NCIMB 9860 / 6-10 {ECO:0000313|Proteomes:UP000001919};
RX PubMed=21304631; DOI=10.4056/sigs.492;
RA Lapidus A., Pukall R., Labuttii K., Copeland A., Del Rio T.G., Nolan M.,
RA Chen F., Lucas S., Tice H., Cheng J.F., Bruce D., Goodwin L., Pitluck S.,
RA Rohde M., Goker M., Pati A., Ivanova N., Mavrommatis K., Chen A.,
RA Palaniappan K., D'haeseleer P., Chain P., Bristow J., Eisen J.A.,
RA Markowitz V., Hugenholtz P., Kyrpides N.C., Klenk H.P.;
RT "Complete genome sequence of Brachybacterium faecium type strain
RT (Schefferle 6-10).";
RL Stand. Genomic Sci. 1:3-11(2009).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
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DR EMBL; CP001643; ACU85858.1; -; Genomic_DNA.
DR RefSeq; WP_015776067.1; NC_013172.1.
DR RefSeq; YP_003155448.1; NC_013172.1.
DR AlphaFoldDB; C7ME51; -.
DR STRING; 446465.Bfae_20510; -.
DR KEGG; bfa:Bfae_20510; -.
DR PATRIC; fig|446465.5.peg.2034; -.
DR eggNOG; COG3920; Bacteria.
DR HOGENOM; CLU_045351_1_0_11; -.
DR OrthoDB; 9767435at2; -.
DR Proteomes; UP000001919; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004673; F:protein histidine kinase activity; IEA:InterPro.
DR Gene3D; 3.30.450.280; GAF domain; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 1.
DR InterPro; IPR038424; H_kinase_PdtaS_GAF_sf.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR013656; PAS_4.
DR InterPro; IPR022066; PdtaS_GAF.
DR InterPro; IPR011495; Sig_transdc_His_kin_sub2_dim/P.
DR InterPro; IPR011102; Sig_transdc_His_kinase_HWE.
DR PANTHER; PTHR41523:SF7; ETHYLENE RESPONSE SENSOR PROTEIN; 1.
DR PANTHER; PTHR41523; TWO-COMPONENT SYSTEM SENSOR PROTEIN; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF07568; HisKA_2; 1.
DR Pfam; PF08448; PAS_4; 1.
DR Pfam; PF12282; PdtaS_GAF; 1.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00911; HWE_HK; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR PROSITE; PS50109; HIS_KIN; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:ACU85858.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000001919};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 292..494
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
SQ SEQUENCE 497 AA; 53530 MW; DBAEB55BF5284205 CRC64;
MPSLSKFLAD NPGLSEKEAD WLQHLVGDWN LLSDLLRSDL VLWIKEESGA LAVAHCRPAT
GSTVYYEDPV GRPSDGGTEG VEIVRLLDGG EASRVPTAIE REGRAATGLL VPVRKNGQTL
AVLAAESPDS DGHPSNNETQ QRKLGHRLLR MLESGAFPIE GAPIPPRRGA PRVGDGVVEL
DDAGVVCWIS PNAISAFHRF GIEGDMEGVT LAELSTEVLQ SRSPVDESLP LVLMGRAAWR
SDMQARGGTL SLRAVPLTEQ GRRTGAVILV RDVTELRRRE RELITKDATI REVHHRVKNN
LQTVAALLRM QSRRMKTDEA REALAEAMRR VSTIALVHES LLQGSQEAVH FDEVIDRCLR
LAVDAASATV HRAGTPQLTD AQVEVRTEKI GRVGSIRAEE ATPLALVVTE LATNAVEHGL
SETGGTLTIR SERTGSHLVI SIEDDGDGMG AAKPTGLGTN IALTLVQGQL GGTLTWEDRP
GGGTRAMVEV YLDPLTL
//
