ID C7MIA5_BRAFD Unreviewed; 347 AA.
AC C7MIA5;
DT 13-OCT-2009, integrated into UniProtKB/TrEMBL.
DT 13-OCT-2009, sequence version 1.
DT 24-JAN-2024, entry version 68.
DE RecName: Full=glutaminase {ECO:0000256|ARBA:ARBA00012918};
DE EC=3.5.1.2 {ECO:0000256|ARBA:ARBA00012918};
GN OrderedLocusNames=Bfae_06680 {ECO:0000313|EMBL:ACU84531.1};
OS Brachybacterium faecium (strain ATCC 43885 / DSM 4810 / JCM 11609 / LMG
OS 19847 / NBRC 14762 / NCIMB 9860 / 6-10).
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Dermabacteraceae;
OC Brachybacterium.
OX NCBI_TaxID=446465 {ECO:0000313|EMBL:ACU84531.1, ECO:0000313|Proteomes:UP000001919};
RN [1] {ECO:0000313|EMBL:ACU84531.1, ECO:0000313|Proteomes:UP000001919}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 43885 / DSM 4810 / JCM 11609 / LMG 19847 / NBRC 14762 /
RC NCIMB 9860 / 6-10 {ECO:0000313|Proteomes:UP000001919};
RX PubMed=21304631; DOI=10.4056/sigs.492;
RA Lapidus A., Pukall R., Labuttii K., Copeland A., Del Rio T.G., Nolan M.,
RA Chen F., Lucas S., Tice H., Cheng J.F., Bruce D., Goodwin L., Pitluck S.,
RA Rohde M., Goker M., Pati A., Ivanova N., Mavrommatis K., Chen A.,
RA Palaniappan K., D'haeseleer P., Chain P., Bristow J., Eisen J.A.,
RA Markowitz V., Hugenholtz P., Kyrpides N.C., Klenk H.P.;
RT "Complete genome sequence of Brachybacterium faecium type strain
RT (Schefferle 6-10).";
RL Stand. Genomic Sci. 1:3-11(2009).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + L-glutamine = L-glutamate + NH4(+);
CC Xref=Rhea:RHEA:15889, ChEBI:CHEBI:15377, ChEBI:CHEBI:28938,
CC ChEBI:CHEBI:29985, ChEBI:CHEBI:58359; EC=3.5.1.2;
CC Evidence={ECO:0000256|ARBA:ARBA00001062};
CC -!- SUBUNIT: Homotetramer. {ECO:0000256|ARBA:ARBA00011881}.
CC -!- SIMILARITY: Belongs to the glutaminase family.
CC {ECO:0000256|ARBA:ARBA00011076}.
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DR EMBL; CP001643; ACU84531.1; -; Genomic_DNA.
DR RefSeq; WP_012804306.1; NC_013172.1.
DR RefSeq; YP_003154121.1; NC_013172.1.
DR AlphaFoldDB; C7MIA5; -.
DR STRING; 446465.Bfae_06680; -.
DR KEGG; bfa:Bfae_06680; -.
DR PATRIC; fig|446465.5.peg.660; -.
DR eggNOG; COG2066; Bacteria.
DR HOGENOM; CLU_027932_1_0_11; -.
DR OrthoDB; 9788822at2; -.
DR Proteomes; UP000001919; Chromosome.
DR GO; GO:0004359; F:glutaminase activity; IEA:UniProtKB-EC.
DR GO; GO:0006541; P:glutamine metabolic process; IEA:InterPro.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR015868; Glutaminase.
DR NCBIfam; TIGR03814; Gln_ase; 1.
DR PANTHER; PTHR12544; GLUTAMINASE; 1.
DR PANTHER; PTHR12544:SF29; GLUTAMINASE; 1.
DR Pfam; PF04960; Glutaminase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000001919}.
SQ SEQUENCE 347 AA; 36586 MW; E5537FB70A3B954C CRC64;
MNSASTALDL YLSRLTTALS TATATGEPEV VVPDRGITGD VETQGDIPEL SFLSGARQDH
LSVAICSVDG EITRSGTDHT FPIQSISKAF AYGAAIDLHG MDHVNSLVDE EPSGEQFNAL
SLDPVTKKPK NPLVNIGAIR THAMLGTTTQ ERTQRLRAVL DAAAGRPLEP HDATWREELK
SADRNLALAY MLRAAGSMTE DAADVVGGYI EGCAVLAGVT DLAVMAATLA SGGTNPLTGE
VVFSRVAARK VLSVMLTCGM YDNAGDWVSD VGLPAKSGVG GGIIAALPSR FGVASYAPQL
DLHGNSVRGT LFFERFSTDF ALHMLDGVEP RDLEECAQEL MEVGTHL
//
