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Database: UniProt
Entry: C7MLD2_CRYCD
LinkDB: C7MLD2_CRYCD
Original site: C7MLD2_CRYCD 
ID   C7MLD2_CRYCD            Unreviewed;       506 AA.
AC   C7MLD2;
DT   13-OCT-2009, integrated into UniProtKB/TrEMBL.
DT   13-OCT-2009, sequence version 1.
DT   16-JAN-2019, entry version 72.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS01081161};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   OrderedLocusNames=Ccur_00010 {ECO:0000313|EMBL:ACU93738.1};
OS   Cryptobacterium curtum (strain ATCC 700683 / DSM 15641 / 12-3).
OC   Bacteria; Actinobacteria; Coriobacteriia; Eggerthellales;
OC   Eggerthellaceae; Cryptobacterium.
OX   NCBI_TaxID=469378 {ECO:0000313|EMBL:ACU93738.1};
RN   [1] {ECO:0000313|EMBL:ACU93738.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 15641 {ECO:0000313|EMBL:ACU93738.1};
RX   PubMed=21304644; DOI=10.40456/sigs.12260;
RA   Mavrommatis K., Pukall R., Rohde C., Chen F., Sims D., Brettin T.,
RA   Kuske C., Detter J.C., Han C., Lapidus A., Copeland A.,
RA   Glavina Del Rio T., Nolan M., Lucas S., Tice H., Cheng J.F., Bruce D.,
RA   Goodwin L., Pitluck S., Ovchinnikova G., Pati A., Ivanova N., Chen A.,
RA   Palaniappan K., Chain P., D'haeseleer P., Goker M., Bristow J.,
RA   Eisen J.A., Markowitz V., Hugenholtz P., Rohde M., Klenk H.P.,
RA   Kyrpides N.C.;
RT   "Complete genome sequence of Cryptobacterium curtum type strain (12-
RT   3).";
RL   Stand. Genomic Sci. 1:93-100(2009).
RN   [2] {ECO:0000313|EMBL:ACU93738.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=DSM 15641 {ECO:0000313|EMBL:ACU93738.1};
RG   US DOE Joint Genome Institute (JGI-PGF);
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E.,
RA   Tice H., Bruce D., Goodwin L., Pitluck S., Kyrpides N., Mavromatis K.,
RA   Ivanova N., Ovchinnikova G., Sims D., Brettin T., Detter J.C., Han C.,
RA   Kuske C., Larimer F., Land M., Hauser L., Markowitz V., Cheng J.-F.,
RA   Hugenholtz P., Woyke T., Wu D., Pukall R., Klenk H.-P., Eisen J.A.;
RT   "The complete genome of Cryptobacter curtum DSM 15641.";
RL   Submitted (AUG-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756121}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS01082709}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
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DR   EMBL; CP001682; ACU93738.1; -; Genomic_DNA.
DR   RefSeq; WP_012802427.1; NC_013170.1.
DR   ProteinModelPortal; C7MLD2; -.
DR   STRING; 469378.Ccur_00010; -.
DR   EnsemblBacteria; ACU93738; ACU93738; Ccur_00010.
DR   KEGG; ccu:Ccur_00010; -.
DR   eggNOG; ENOG4105CI4; Bacteria.
DR   eggNOG; COG0593; LUCA.
DR   HOGENOM; HOG000235658; -.
DR   KO; K02313; -.
DR   OMA; REFNPLF; -.
DR   OrthoDB; 219876at2; -.
DR   BioCyc; CCUR469378:G1GFI-1-MONOMER; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   Gene3D; 3.30.300.180; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR038454; DnaA_N_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756129};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS01082702};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00756116};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS01082706};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756117}.
FT   DOMAIN      193    331       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      414    482       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     201    208       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   506 AA;  57207 MW;  9A419CCBA2C9385B CRC64;
     MSADKYDALW NTVVERIKTY ENIDASQIDA FFSRLVPQAF SEGFLMLTSD TEFIKKWIES
     HYTDVIKQAL EEIYQVPFTI AIEVDTPSSA AEGVQQDQQN DVTHTTPQHT SQQSEPSVKS
     LNERGSQSPF SPVSNNHSAS PFTPTAEETI SHNQDFLNSV ISGYSFESFV IGTSNKMAYS
     MAVAVAETPG QPQFNPLFIY GKSGLGKTHL LRSIQNYVHH AYPTAKTVYV DTMALVNDYT
     DAAISRSNKS FSQFKQKYET ADVLLIDDVQ GLQNKKETLN MVFQILNSMI DRGKQVVFSA
     DRAPKNIDID ERYMSRFNMG GTCDIQPPEL ETKLGIIKNY LEECRRGAND DFSIPADVQE
     YIAQNSSSNI RELKSAVTKV VFELRNNGKS EITIDEAARL LTDHFSGGAM KRLSISDIQT
     AVEQYYNVSH TELVGRKRSA NITYARQIAI YLCRTMIDIP FNSIGTEFNR DHSTIMYSFR
     SVEEKVKESR QVNEELEIIR QMIIEQ
//
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