ID C7NCK7_LEPBD Unreviewed; 691 AA.
AC C7NCK7;
DT 13-OCT-2009, integrated into UniProtKB/TrEMBL.
DT 13-OCT-2009, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN OrderedLocusNames=Lebu_1991 {ECO:0000313|EMBL:ACV39853.1};
OS Leptotrichia buccalis (strain ATCC 14201 / DSM 1135 / JCM 12969 / NCTC
OS 10249 / C-1013-b).
OC Bacteria; Fusobacteriota; Fusobacteriia; Fusobacteriales; Leptotrichiaceae;
OC Leptotrichia.
OX NCBI_TaxID=523794 {ECO:0000313|EMBL:ACV39853.1, ECO:0000313|Proteomes:UP000001910};
RN [1] {ECO:0000313|EMBL:ACV39853.1, ECO:0000313|Proteomes:UP000001910}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 14201 / DSM 1135 / JCM 12969 / NCTC 10249 / C-1013-b
RC {ECO:0000313|Proteomes:UP000001910};
RX PubMed=21304648; DOI=10.4056/sigs.1854;
RA Ivanova N., Gronow S., Lapidus A., Copeland A., Glavina Del Rio T.,
RA Nolan M., Lucas S., Chen F., Tice H., Cheng J.F., Saunders E., Bruce D.,
RA Goodwin L., Brettin T., Detter J.C., Han C., Pitluck S., Mikhailova N.,
RA Pati A., Mavrommatis K., Chen A., Palaniappan K., Land M., Hauser L.,
RA Chang Y.J., Jeffries C.D., Chain P., Rohde C., Goker M., Bristow J.,
RA Eisen J.A., Markowitz V., Hugenholtz P., Kyrpides N.C., Klenk H.P.;
RT "Complete genome sequence of Leptotrichia buccalis type strain (C-1013-
RT b).";
RL Stand. Genomic Sci. 1:126-132(2009).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
CC -!- SIMILARITY: Belongs to the N(4)/N(6)-methyltransferase family.
CC {ECO:0000256|ARBA:ARBA00006594}.
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DR EMBL; CP001685; ACV39853.1; -; Genomic_DNA.
DR RefSeq; WP_015770191.1; NC_013192.1.
DR AlphaFoldDB; C7NCK7; -.
DR STRING; 523794.Lebu_1991; -.
DR REBASE; 21855; M.LbuDORF1991P.
DR KEGG; lba:Lebu_1991; -.
DR eggNOG; COG0827; Bacteria.
DR HOGENOM; CLU_025185_0_0_0; -.
DR OrthoDB; 9815272at2; -.
DR Proteomes; UP000001910; Chromosome.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR011639; MethylTrfase_TaqI-like_dom.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR33841; DNA METHYLTRANSFERASE YEEA-RELATED; 1.
DR PANTHER; PTHR33841:SF5; TYPE II METHYLTRANSFERASE M.HINDII; 1.
DR Pfam; PF07669; Eco57I; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:ACV39853.1};
KW Restriction system {ECO:0000256|ARBA:ARBA00022747};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:ACV39853.1}.
FT DOMAIN 333..440
FT /note="Type II methyltransferase M.TaqI-like"
FT /evidence="ECO:0000259|Pfam:PF07669"
SQ SEQUENCE 691 AA; 82482 MW; 5518517FBE7CDE3F CRC64;
MNKKIVILQE ILDYQEKIFN FIKREEFFLE TSLNEEKLLK LISGLAIISS IYEKFTTKLI
TIYCDIFMKT EKEKDGIIQN NKSIGNLSKM IKELKLEVDE MYRLLKLNND FEKNDILKKD
SNLLTYGDLI VHMNKIYQKR NKYVHGAFEI NENIDKEKFE KYVLDTLDKE SAILLVLKNA
FISKIPYYLI EKEELTKNYK KYEELYNNFF ENIDNEIIKE KSQFFTPIAI SQKLVDDLKH
LNKKFEKENI KILDPSCGFG ILTINLLEKI VEISSDSNKR INKIEVDMID IDEKCIENCK
IIMKEFLEKN NLNDLVEVNY IIGNYLNYEI KRKYDFIVQN PPFKKIKKEE KVKYDGEITK
YINGQANLYH LFIIKSLKLL DEKGILFTIS PKNFLSGKYT ENLRKFLFNN YSLTRLHLFD
ERKKIFKNII QEICITQIEK RKHKNIKISY NGSKPFELDR EILFLKRKNN ILLSPRNREE
SNFIKSINEI FVKNNVFSFH PGKVVQFRVD KKNLSSEKFN KEKKQVPLLV PKHLKNERIE
YEDLDKKKNK SISIFYNEET QNLFLKNKRY IILNKNSGKE EKKLIKPVLY DGIFDIEYIA
LDNNLAYIEF FDNNVSDFIF YGVFCVLNSK QFDNYYRMIN GSHTLNSYEF QNLLFPKKEI
LEKIGLEYLN TKKENSIEMC SEIFEKYIKN K
//
