ID C7NWS0_HALMD Unreviewed; 665 AA.
AC C7NWS0;
DT 13-OCT-2009, integrated into UniProtKB/TrEMBL.
DT 13-OCT-2009, sequence version 1.
DT 27-MAR-2024, entry version 66.
DE RecName: Full=acetate--CoA ligase {ECO:0000256|ARBA:ARBA00013275};
DE EC=6.2.1.1 {ECO:0000256|ARBA:ARBA00013275};
GN OrderedLocusNames=Hmuk_2167 {ECO:0000313|EMBL:ACV48280.1};
OS Halomicrobium mukohataei (strain ATCC 700874 / DSM 12286 / JCM 9738 / NCIMB
OS 13541) (Haloarcula mukohataei).
OC Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC Haloarculaceae; Halomicrobium.
OX NCBI_TaxID=485914 {ECO:0000313|EMBL:ACV48280.1, ECO:0000313|Proteomes:UP000001746};
RN [1] {ECO:0000313|EMBL:ACV48280.1, ECO:0000313|Proteomes:UP000001746}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700874 / DSM 12286 / JCM 9738 / NCIMB 13541
RC {ECO:0000313|Proteomes:UP000001746};
RX PubMed=21304667; DOI=10.4056/sigs.42644;
RA Tindall B.J., Schneider S., Lapidus A., Copeland A., Glavina Del Rio T.,
RA Nolan M., Lucas S., Chen F., Tice H., Cheng J.F., Saunders E., Bruce D.,
RA Goodwin L., Pitluck S., Mikhailova N., Pati A., Ivanova N., Mavrommatis K.,
RA Chen A., Palaniappan K., Chain P., Land M., Hauser L., Chang Y.J.,
RA Jeffries C.D., Brettin T., Han C., Rohde M., Goker M., Bristow J.,
RA Eisen J.A., Markowitz V., Hugenholtz P., Klenk H.P., Kyrpides N.C.,
RA Detter J.C.;
RT "Complete genome sequence of Halomicrobium mukohataei type strain (arg-
RT 2).";
RL Stand. Genomic Sci. 1:270-277(2009).
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DR EMBL; CP001688; ACV48280.1; -; Genomic_DNA.
DR RefSeq; WP_015763122.1; NC_013202.1.
DR AlphaFoldDB; C7NWS0; -.
DR STRING; 485914.Hmuk_2167; -.
DR GeneID; 8411706; -.
DR KEGG; hmu:Hmuk_2167; -.
DR eggNOG; arCOG04201; Archaea.
DR HOGENOM; CLU_000022_3_6_2; -.
DR OrthoDB; 371752at2157; -.
DR Proteomes; UP000001746; Chromosome.
DR GO; GO:0003987; F:acetate-CoA ligase activity; IEA:InterPro.
DR GO; GO:0016208; F:AMP binding; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0019427; P:acetyl-CoA biosynthetic process from acetate; IEA:InterPro.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR InterPro; IPR011904; Ac_CoA_lig.
DR InterPro; IPR032387; ACAS_N.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR NCBIfam; TIGR02188; Ac_CoA_lig_AcsA; 1.
DR PANTHER; PTHR24095; ACETYL-COENZYME A SYNTHETASE; 1.
DR PANTHER; PTHR24095:SF14; ACETYL-COENZYME A SYNTHETASE 1; 1.
DR Pfam; PF16177; ACAS_N; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF13193; AMP-binding_C; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000313|EMBL:ACV48280.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000001746}.
FT DOMAIN 35..86
FT /note="Acetyl-coenzyme A synthetase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16177"
FT DOMAIN 89..480
FT /note="AMP-dependent synthetase/ligase"
FT /evidence="ECO:0000259|Pfam:PF00501"
FT DOMAIN 550..628
FT /note="AMP-binding enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13193"
FT REGION 642..665
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 665 AA; 74773 MW; 128D751C4854DBCC CRC64;
MPDEGPELEA RLTEQEYFRP PTDFVGQANV TDPDIHERFD ENYPEAFEEY AELLDWDEHW
DEVLDDSNPP FYEWFTGGKL NASHNCIDRH LDERKNQAAI IWEGTDADES ETITYQDLYN
RVNAMAASLQ DVDVREDDVV TCHLPMLPAL PVTMLACARI GAPHSEVFAG FSAQALADRI
DSADSDVVVT CDGYYRRGEF LNHKEKCDEA LEAAESDVDT VLLWTREDEL HPDVEIGEDD
PYVLVDDLLA DNERARVDPV SRDAEDPLFL MYTSGTTGQP KGCQHRTGGY LSYVTATSKN
VLDIKPEDTY WCAADIGWIT GHSYIVYGPL SLGTTSVMYE DTPDYPHKGR IWEIAERYDV
DIFHTSPTAV RMFMKWGEEY VQDYDFDFRH MTTVGEPIQP EAWLWYYKYI GGEDAAIVDT
WWQTETGGHL ITNLPALDDM KPGSAGKAVP GIQPAIYDDN GDPIEPASGR AGNLVIEKPW
PGMLQTVYGN DERFIEEYWQ DFSDTDSDDP EDWVYKAGDG AVHGQDSYYR VLGRLDDVMN
VAGHRLGTME LESAVAEVED AAEAAVASRE DAEKGEVPDV YVVLRDGIEP SEAVRDRIVS
AVEDEIGKFA RPANVIFCGD LPKTRSGKIM RRILENISNG EELGNTTTLR DPSVPEEIRD
QVQGD
//
