ID C7RB80_KANKD Unreviewed; 543 AA.
AC C7RB80;
DT 13-OCT-2009, integrated into UniProtKB/TrEMBL.
DT 13-OCT-2009, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=Tryptophan halogenase {ECO:0000313|EMBL:ACV26522.1};
GN OrderedLocusNames=Kkor_1103 {ECO:0000313|EMBL:ACV26522.1};
OS Kangiella koreensis (strain DSM 16069 / KCTC 12182 / SW-125).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Kangiellales; Kangiellaceae;
OC Kangiella.
OX NCBI_TaxID=523791 {ECO:0000313|EMBL:ACV26522.1, ECO:0000313|Proteomes:UP000001231};
RN [1] {ECO:0000313|EMBL:ACV26522.1, ECO:0000313|Proteomes:UP000001231}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 16069 / KCTC 12182 / SW-125
RC {ECO:0000313|Proteomes:UP000001231};
RX PubMed=21304661; DOI=10.4056/sigs.36635;
RA Han C., Sikorski J., Lapidus A., Nolan M., Glavina Del Rio T., Tice H.,
RA Cheng J.F., Lucas S., Chen F., Copeland A., Ivanova N., Mavromatis K.,
RA Ovchinnikova G., Pati A., Bruce D., Goodwin L., Pitluck S., Chen A.,
RA Palaniappan K., Land M., Hauser L., Chang Y.J., Jeffries C.D., Chain P.,
RA Saunders E., Brettin T., Goker M., Tindall B.J., Bristow J., Eisen J.A.,
RA Markowitz V., Hugenholtz P., Kyrpides N.C., Klenk H.P., Detter J.C.;
RT "Complete genome sequence of Kangiella koreensis type strain (SW-125).";
RL Stand. Genomic Sci. 1:226-233(2009).
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DR EMBL; CP001707; ACV26522.1; -; Genomic_DNA.
DR RefSeq; WP_012801036.1; NC_013166.1.
DR AlphaFoldDB; C7RB80; -.
DR STRING; 523791.Kkor_1103; -.
DR KEGG; kko:Kkor_1103; -.
DR eggNOG; COG0644; Bacteria.
DR HOGENOM; CLU_022247_0_0_6; -.
DR InParanoid; C7RB80; -.
DR OrthoDB; 5751025at2; -.
DR Proteomes; UP000001231; Chromosome.
DR GO; GO:0004497; F:monooxygenase activity; IEA:InterPro.
DR GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR006905; Flavin_halogenase.
DR InterPro; IPR033856; Trp_halogen.
DR PANTHER; PTHR43747; FAD-BINDING PROTEIN; 1.
DR PANTHER; PTHR43747:SF4; FLAVIN-DEPENDENT TRYPTOPHAN HALOGENASE; 1.
DR Pfam; PF04820; Trp_halogenase; 1.
DR PIRSF; PIRSF011396; Trp_halogenase; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE 4: Predicted;
KW FAD {ECO:0000256|PIRSR:PIRSR011396-2};
KW Flavoprotein {ECO:0000256|PIRSR:PIRSR011396-2};
KW Nucleotide-binding {ECO:0000256|PIRSR:PIRSR011396-2};
KW Reference proteome {ECO:0000313|Proteomes:UP000001231}.
FT ACT_SITE 82
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-1"
FT BINDING 82
FT /ligand="7-chloro-L-tryptophan"
FT /ligand_id="ChEBI:CHEBI:58713"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 185
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 337
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 346
FT /ligand="L-tryptophan"
FT /ligand_id="ChEBI:CHEBI:57912"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
SQ SEQUENCE 543 AA; 61993 MW; C5728A9AF0DD1BB1 CRC64;
MNKRRRLLIV GGGSSGWIVA AYLNSALKAL KAPIDVEITL VESPDIPRIS VGEATIPSIR
HLLATIGINE TDFMVATDAT FKQSIRYVNW EKLNSFYHHP FTRVRKQPLD DLAENWLKSD
RSIPFMETCS EQPIICEMGL APVMYSPWDM GTPLSYAYHM NAQKFADYLR DISVSRGVNH
VLANVTDIEM KSDKQIKAVN TDNAGRLEAD LFIDCTGFRA KLIEEKLGVG FEDCSQWLLC
DRAVAMHVPY DKYYPGMVRP YTTATALSNG WVWDIPMQSQ RSLGYVHSSA FISKEAAERE
LRAYQGGSCD ELPARFVDFK VGRRHKAWEG NCIAIGLSGG FIEPLESTGL YLSDLGAVAL
AEYFPYRDED IEALSFRYNR ILSNRFYEIL DFINMHYCLT RRADTEFWRT VQKPEHITDR
LKTKLEFWER KIPSMSDFDD QFFLNQNTGS LGNLGANFDS RAPVDTAGLW NHESYQCILY
GMHFKSKIPS IDISTASQLN VHPYILNRLQ QAKNKLPKHA DWLQRTLGMR QYRYSSKPAG
WVV
//
