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Database: UniProt
Entry: C7XXK1_9LACO
LinkDB: C7XXK1_9LACO
Original site: C7XXK1_9LACO 
ID   C7XXK1_9LACO            Unreviewed;       439 AA.
AC   C7XXK1;
DT   13-OCT-2009, integrated into UniProtKB/TrEMBL.
DT   13-OCT-2009, sequence version 1.
DT   13-FEB-2019, entry version 65.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377,
GN   ECO:0000313|EMBL:EEU29752.1};
GN   ORFNames=HMPREF0501_01546 {ECO:0000313|EMBL:EEU29752.1};
OS   Lactobacillus coleohominis 101-4-CHN.
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Lactobacillus.
OX   NCBI_TaxID=575594 {ECO:0000313|EMBL:EEU29752.1, ECO:0000313|Proteomes:UP000003987};
RN   [1] {ECO:0000313|EMBL:EEU29752.1, ECO:0000313|Proteomes:UP000003987}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=101-4-CHN {ECO:0000313|EMBL:EEU29752.1,
RC   ECO:0000313|Proteomes:UP000003987};
RG   The Broad Institute Genome Sequencing Platform;
RA   Ward D., Young S.K., Zeng Q., Koehrsen M., Alvarado L., Berlin A.,
RA   Borenstein D., Chen Z., Engels R., Freedman E., Gellesch M.,
RA   Goldberg J., Griggs A., Gujja S., Heiman D., Hepburn T., Howarth C.,
RA   Jen D., Larson L., Lewis B., Mehta T., Park D., Pearson M.,
RA   Roberts A., Saif S., Shea T., Shenoy N., Sisk P., Stolte C., Sykes S.,
RA   Walk T., White J., Yandava C., Liu Y., Xu Q., Lander E., Nusbaum C.,
RA   Galagan J., Birren B.;
RT   "The Genome Sequence of Lactobacillus coleohominis strain 101-4-CHN.";
RL   Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS01082709}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
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DR   EMBL; GG698806; EEU29752.1; -; Genomic_DNA.
DR   RefSeq; WP_006917487.1; NZ_GG698806.1.
DR   ProteinModelPortal; C7XXK1; -.
DR   STRING; 575594.HMPREF0501_01546; -.
DR   EnsemblBacteria; EEU29752; EEU29752; HMPREF0501_01546.
DR   eggNOG; ENOG4105CI4; Bacteria.
DR   eggNOG; COG0593; LUCA.
DR   OrthoDB; 219876at2; -.
DR   BioCyc; GCF_000161935-HMP:HMPREF0501_RS07930-MONOMER; -.
DR   Proteomes; UP000003987; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   Gene3D; 3.30.300.180; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR038454; DnaA_N_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756129};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000003987};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS01082702};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00756116};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS01082706};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756117};
KW   Reference proteome {ECO:0000313|Proteomes:UP000003987}.
FT   DOMAIN      135    264       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      347    416       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     143    150       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
FT   COILED      267    287       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   439 AA;  49899 MW;  8EF417D8B830F24F CRC64;
     MTELDSLWET VQNEFKQSIT PPTYENVVAP AKAYSLQNHQ LTVVLPTDYH LDWWKKSLNI
     QLKHILHEKT GEEIEPIYVL TKDLMKKADP APDQPTYKTQ TPLNPEYTFD NFVEGRTNQF
     AYASAFAASE QPGGLYNPLL IYGDVGLGKT HLMQAIANNM LVHNPDAKIK YVTSENFMND
     YINSIKTGTQ EQFRQEYRDL DALLVDDVQF FSEKNGTQLE FFNTFNSLHD NNKQIVLTAD
     QNPKEIPNLT DRLVSRFVWG LTVEITAPDL ETRIAILNRK AEEENLQGIP NEVFNFIASK
     INTNVRELEG ALMRVRVFAD LHKTSINEAV AREALQGIGN DAPATLSIDL IQKKVAAHFN
     INQSDITGKK RVKNIVIPRQ IAMYLSRELT DNSLPRIGKE FGGKDHTTVL HAIDKIEKQM
     TSDSNLQKEI NSLKKDLRP
//
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