ID C8NFI6_9LACT Unreviewed; 595 AA.
AC C8NFI6;
DT 03-NOV-2009, integrated into UniProtKB/TrEMBL.
DT 03-NOV-2009, sequence version 1.
DT 24-JAN-2024, entry version 41.
DE SubName: Full=Penicillin-binding protein, transpeptidase domain protein {ECO:0000313|EMBL:EEW37591.1};
GN Name=pbpC {ECO:0000313|EMBL:EEW37591.1};
GN ORFNames=HMPREF0444_0681 {ECO:0000313|EMBL:EEW37591.1};
OS Granulicatella adiacens ATCC 49175.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Carnobacteriaceae;
OC Granulicatella.
OX NCBI_TaxID=638301 {ECO:0000313|EMBL:EEW37591.1, ECO:0000313|Proteomes:UP000005926};
RN [1] {ECO:0000313|EMBL:EEW37591.1, ECO:0000313|Proteomes:UP000005926}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 49175 {ECO:0000313|EMBL:EEW37591.1,
RC ECO:0000313|Proteomes:UP000005926};
RA Muzny D., Qin X., Deng J., Jiang H., Liu Y., Qu J., Song X.-Z., Zhang L.,
RA Thornton R., Coyle M., Francisco L., Jackson L., Javaid M., Korchina V.,
RA Kovar C., Mata R., Mathew T., Ngo R., Nguyen L., Nguyen N., Okwuonu G.,
RA Ongeri F., Pham C., Simmons D., Wilczek-Boney K., Hale W., Jakkamsetti A.,
RA Pham P., Ruth R., San Lucas F., Warren J., Zhang J., Zhao Z., Zhou C.,
RA Zhu D., Lee S., Bess C., Blankenburg K., Forbes L., Fu Q., Gubbala S.,
RA Hirani K., Jayaseelan J.C., Lara F., Munidasa M., Palculict T., Patil S.,
RA Pu L.-L., Saada N., Tang L., Weissenberger G., Zhu Y., Hemphill L.,
RA Shang Y., Youmans B., Ayvaz T., Ross M., Santibanez J., Aqrawi P.,
RA Gross S., Joshi V., Fowler G., Nazareth L., Reid J., Worley K.,
RA Petrosino J., Highlander S., Gibbs R.;
RL Submitted (AUG-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004162};
CC Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004162}. Membrane
CC {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004167}.
CC -!- SIMILARITY: Belongs to the transpeptidase family.
CC {ECO:0000256|ARBA:ARBA00007171}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EEW37591.1}.
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DR EMBL; ACKZ01000014; EEW37591.1; -; Genomic_DNA.
DR RefSeq; WP_005605984.1; NZ_GG694015.1.
DR AlphaFoldDB; C8NFI6; -.
DR STRING; 638301.HMPREF0444_0681; -.
DR eggNOG; COG0768; Bacteria.
DR HOGENOM; CLU_009289_6_1_9; -.
DR Proteomes; UP000005926; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR Gene3D; 2.20.70.70; -; 1.
DR Gene3D; 3.30.70.2110; -; 1.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR005311; PBP_dimer.
DR InterPro; IPR036138; PBP_dimer_sf.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR PANTHER; PTHR30627:SF1; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE FTSI; 1.
DR Pfam; PF03717; PBP_dimer; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF56519; Penicillin binding protein dimerisation domain; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005926};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 16..36
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 64..235
FT /note="Penicillin-binding protein dimerisation"
FT /evidence="ECO:0000259|Pfam:PF03717"
FT DOMAIN 277..585
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
SQ SEQUENCE 595 AA; 66034 MW; 3515A2CFCAB430C3 CRC64;
MKKTNNNNIA RNRRRASFIL MGLASVLFLI FSVRFFRIMV LGNIHNVDLR AEINDKIHQK
RTLAAKRGTI YDASGSPIAV DATNYSIYAV LTNQWSKNAE TPDYVTDINK TAEALSKHIS
LSKEEIVKIL NQKDVSQVEF GNAGKNLSVQ VKDKIEAEKL PGIKFSESPA RYYPNGIFAS
HLIGYTDSVE ETVDHKTTIS LVGKTGLEGL YNEQLTGTAG EVEYTVDGNG YVISDTEKVT
KQPKDGKDIT LTLDKRLQTY LESLVSAADK QYQPVQMTAM LVDPKSGNIV AATQRPTYNS
TTKEGIDVQW NNLLTDQAYE PGSTMKVLAL AAAINEGVFD PNERYQSGSV KIYTDLVRDY
NKVGWGNITY LEGLAHSSNV AFVHVIQKIG AEKWKQYLEA FGFSKSTNSG FANEISGSNP
FNSYLQQLST GFGQGITVTV YQMMQAFTAI ANGGQMQKLR LVDHFTEPNT DKETPNPVNS
LGKVISPEAA KKTLEYLYQA TRMKNGTAYE FNIDGEEIAA KTGTAEIINP ETGKYYSNGN
NYIFSVVGFA PYNDPKYILY VTVKQPRVAV TGNTILKEIF NPLMKRSLEY SRLSE
//
