ID C8V691_EMENI Unreviewed; 1052 AA.
AC C8V691;
DT 03-NOV-2009, integrated into UniProtKB/TrEMBL.
DT 03-NOV-2009, sequence version 1.
DT 24-JAN-2024, entry version 69.
DE SubName: Full=NRPS-like enzyme, putative (JCVI) {ECO:0000313|EMBL:CBF75107.1};
GN ORFNames=ANIA_10486 {ECO:0000313|EMBL:CBF75107.1};
OS Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 /
OS M139) (Aspergillus nidulans).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Nidulantes.
OX NCBI_TaxID=227321 {ECO:0000313|EMBL:CBF75107.1, ECO:0000313|Proteomes:UP000000560};
RN [1] {ECO:0000313|Proteomes:UP000000560}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139
RC {ECO:0000313|Proteomes:UP000000560};
RX PubMed=16372000; DOI=10.1038/nature04341;
RA Galagan J.E., Calvo S.E., Cuomo C., Ma L.J., Wortman J.R., Batzoglou S.,
RA Lee S.I., Basturkmen M., Spevak C.C., Clutterbuck J., Kapitonov V.,
RA Jurka J., Scazzocchio C., Farman M., Butler J., Purcell S., Harris S.,
RA Braus G.H., Draht O., Busch S., D'Enfert C., Bouchier C., Goldman G.H.,
RA Bell-Pedersen D., Griffiths-Jones S., Doonan J.H., Yu J., Vienken K.,
RA Pain A., Freitag M., Selker E.U., Archer D.B., Penalva M.A., Oakley B.R.,
RA Momany M., Tanaka T., Kumagai T., Asai K., Machida M., Nierman W.C.,
RA Denning D.W., Caddick M., Hynes M., Paoletti M., Fischer R., Miller B.,
RA Dyer P., Sachs M.S., Osmani S.A., Birren B.W.;
RT "Sequencing of Aspergillus nidulans and comparative analysis with A.
RT fumigatus and A. oryzae.";
RL Nature 438:1105-1115(2005).
RN [2] {ECO:0000313|Proteomes:UP000000560}
RP GENOME REANNOTATION.
RC STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139
RC {ECO:0000313|Proteomes:UP000000560};
RX PubMed=19146970; DOI=10.1016/j.fgb.2008.12.003;
RA Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J.,
RA Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H.,
RA Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M.,
RA Estrada C.G., Geysens S., Goldman G., de Groot P.W., Hansen K.,
RA Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G.,
RA Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L.,
RA Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M.,
RA van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P.,
RA Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J.,
RA Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A.,
RA Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X.,
RA Robson G., Seiboth B., van Solingen P., Specht T., Sun J.,
RA Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H.,
RA van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y.,
RA Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J.,
RA Oliver S.G., Turner G.;
RT "The 2008 update of the Aspergillus nidulans genome annotation: a community
RT effort.";
RL Fungal Genet. Biol. 46:S2-13(2009).
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DR EMBL; BN001302; CBF75107.1; -; Genomic_DNA.
DR AlphaFoldDB; C8V691; -.
DR STRING; 227321.C8V691; -.
DR EnsemblFungi; CBF75107; CBF75107; ANIA_10486.
DR VEuPathDB; FungiDB:AN10486; -.
DR eggNOG; KOG1178; Eukaryota.
DR HOGENOM; CLU_002220_2_1_1; -.
DR InParanoid; C8V691; -.
DR OMA; QNMGYAQ; -.
DR Proteomes; UP000000560; Chromosome II.
DR GO; GO:0031956; F:medium-chain fatty acid-CoA ligase activity; IBA:GO_Central.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0006631; P:fatty acid metabolic process; IBA:GO_Central.
DR GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR GO; GO:0019748; P:secondary metabolic process; NAS:AspGD.
DR GO; GO:0044550; P:secondary metabolite biosynthetic process; IEA:UniProt.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR013120; Far_NAD-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR PANTHER; PTHR43439:SF2; ENZYME, PUTATIVE (JCVI)-RELATED; 1.
DR PANTHER; PTHR43439; PHENYLACETATE-COENZYME A LIGASE; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF07993; NAD_binding_4; 1.
DR Pfam; PF00550; PP-binding; 1.
DR SMART; SM00823; PKS_PP; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR SUPFAM; SSF47336; ACP-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
DR PROSITE; PS50075; CARRIER; 1.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000000560}.
FT DOMAIN 553..634
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1052 AA; 116760 MW; 2EE8D8A682CEF37A CRC64;
MLSTIRPQAP THIDKLAHDT EDVASPQAEP LTVDELVRHR ASLGPSQPVV YYPRAGIEYS
EFPLQNLDVF AYRVAKILAE KIPPRKSSSE CPAVVALLGP SNLDYLVLLL AVTKLGHAGL
LLSTRISVEA HVSLIERTNA QHMFVHGSFR DIAAKVSERI PLVQVHSIPS EENYDYHIPD
EPIDTNLLSH LDPEVETKHL AWIIHSSGST GLPKPIFQSQ RAAVKNYAGN MNMRGFITLP
LYHNHGICCL FRTIYSNKTL HLYNPQLPLT SQYLVEIMRS YNFEIFYGVP YALKLLAESE
EGIEALAKLK AVMFGGSPCP DSLGNLLVEN GVNLIAHYGS TETGQLMTSM RPPGDKRWDW
LRPSETVKKY LRMEERYPGI YESVVLDGWP SKVMSNRPDG AYATKDLFLK HPEMEAYKYY
SRLDDTITLV NGEKVIPLDL EGRVRQLSVV ADALAFGIGK SNIGLAVIRA PEAASMTDEQ
VIDAIWPAVE DAHQTLPAYG LLPKNMVRVL PADAPYARTD KGTVIRQAFY RDFADLIEAS
YEAGDDMTGT MLLSEEELKA FLHKELSAIV PARTTNGFTD EEDFFSLGMD SLQASQLRSV
LVKSLDTKGY KLGLNVVFEH PSIASLARYL FSLTSKTLET MASIEEQMEA LISKYSDFEH
HVPRPNELSG RYIVVTGATG SLGCHVVAKL STLPDVQKIY CFVRANSTLD AYGRLLGSLR
TRRVYDTLST SAKNKLIALP SNLALATLGL DTMTYNTLTS TITDIIHCAW SVNFTLHLSS
FEKDNIAGIQ HLANLCLRAQ RPAPATLNFC SSISAVVRSP EPSIPESLPL SLAHAQAMGY
AQSKLVAEHL CVKAYQQTGL CTRVLRIGQV VADTENGIWN TTEAIPLMIQ SATTIGALPK
LDEFHRWLPV NTVAGVVVDI ALSESDVDGP KDAQAIYNII SPYPFHWTNE LLPCLRDAGL
VFEELDTRTW LKRLRESNPD PQANPPIKLV DFWTGKYDHD FPPRVVGWET GKTKAVSRTF
GQAKKLQRDI VQKMMSYFFG VDGWGKGKVK LT
//
