ID C8WLM5_EGGLE Unreviewed; 555 AA.
AC C8WLM5;
DT 03-NOV-2009, integrated into UniProtKB/TrEMBL.
DT 03-NOV-2009, sequence version 1.
DT 27-MAR-2024, entry version 71.
DE SubName: Full=Fumarate reductase/succinate dehydrogenase flavoprotein domain protein {ECO:0000313|EMBL:ACV56488.1};
DE Flags: Precursor;
GN OrderedLocusNames=Elen_2533 {ECO:0000313|EMBL:ACV56488.1};
OS Eggerthella lenta (strain ATCC 25559 / DSM 2243 / CCUG 17323 / JCM 9979 /
OS KCTC 3265 / NCTC 11813 / VPI 0255 / 1899 B) (Eubacterium lentum).
OC Bacteria; Actinomycetota; Coriobacteriia; Eggerthellales; Eggerthellaceae;
OC Eggerthella.
OX NCBI_TaxID=479437 {ECO:0000313|EMBL:ACV56488.1, ECO:0000313|Proteomes:UP000001377};
RN [1] {ECO:0000313|EMBL:ACV56488.1, ECO:0000313|Proteomes:UP000001377}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25559 / DSM 2243 / CCUG 17323 / JCM 9979 / KCTC 3265 /
RC NCTC 11813 / VPI 0255 / 1899 B {ECO:0000313|Proteomes:UP000001377};
RX PubMed=21304654; DOI=10.4056/sigs.33592;
RA Saunders E., Pukall R., Abt B., Lapidus A., Glavina Del Rio T.,
RA Copeland A., Tice H., Cheng J.F., Lucas S., Chen F., Nolan M., Bruce D.,
RA Goodwin L., Pitluck S., Ivanova N., Mavromatis K., Ovchinnikova G.,
RA Pati A., Chen A., Palaniappan K., Land M., Hauser L., Chang Y.J.,
RA Jeffries C.D., Chain P., Meincke L., Sims D., Brettin T., Detter J.C.,
RA Goker M., Bristow J., Eisen J.A., Markowitz V., Hugenholtz P.,
RA Kyrpides N.C., Klenk H.P., Han C.;
RT "Complete genome sequence of Eggerthella lenta type strain (IPP VPI
RT 0255).";
RL Stand. Genomic Sci. 1:174-182(2009).
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
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DR EMBL; CP001726; ACV56488.1; -; Genomic_DNA.
DR RefSeq; WP_015761241.1; NC_013204.1.
DR AlphaFoldDB; C8WLM5; -.
DR SMR; C8WLM5; -.
DR STRING; 479437.Elen_2533; -.
DR PaxDb; 479437-Elen_2533; -.
DR GeneID; 69511863; -.
DR KEGG; ele:Elen_2533; -.
DR eggNOG; COG1053; Bacteria.
DR HOGENOM; CLU_011398_4_3_11; -.
DR OrthoDB; 9813348at2; -.
DR BioCyc; ELEN479437:G1GFY-2556-MONOMER; -.
DR Proteomes; UP000001377; Chromosome.
DR GO; GO:0033765; F:steroid dehydrogenase activity, acting on the CH-CH group of donors; IEA:UniProt.
DR GO; GO:0008202; P:steroid metabolic process; IEA:UniProt.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR Gene3D; 3.90.700.10; Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain; 1.
DR InterPro; IPR003953; FAD-binding_2.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR027477; Succ_DH/fumarate_Rdtase_cat_sf.
DR InterPro; IPR006311; TAT_signal.
DR InterPro; IPR019546; TAT_signal_bac_arc.
DR NCBIfam; TIGR01409; TAT_signal_seq; 1.
DR PANTHER; PTHR43400:SF7; FAD_BINDING_2 DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR43400; FUMARATE REDUCTASE; 1.
DR Pfam; PF00890; FAD_binding_2; 1.
DR Pfam; PF10518; TAT_signal; 1.
DR PRINTS; PR00411; PNDRDTASEI.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR SUPFAM; SSF56425; Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
DR PROSITE; PS51318; TAT; 1.
PE 4: Predicted;
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000001377}.
FT DOMAIN 74..508
FT /note="FAD-dependent oxidoreductase 2 FAD binding"
FT /evidence="ECO:0000259|Pfam:PF00890"
SQ SEQUENCE 555 AA; 59799 MW; 5A06B06042F4C741 CRC64;
MNLNRRDFLK GGALIGGTAA LGTMFGCAAS PKGSTSGAVS TDAGLPAGTT AEDFAQSSVS
LDPITAFSEE KTYDIVVVGA GTAGVPAVYS ALEEGATVAC LQREGTVQAN GNGSSGIILE
ESNEAGILQY MQAWRKAGGY RMNPDLLKLF VDHSGETHMW MLQRSAEVDY IPSPISATKT
TYDEGNFCTA VIKTYGPKPK NHTDIMALLA AAAEKQGAEF FYSTPAVQLV KDESGAITGV
IGKSENDYIK FSATKAVILA AGDYQNNESM VERYSPDVVR FGRKQMNRTG DGILLGMTAG
GAMSPVNHAK TMHDMDAAPM LMTRIPLMAL DEKGERFMNE EIPMESWDLT LNTRKDVEDP
GRFFRIFDSD YMVKYGSKTS IESLENYIPG FKESPENVYP SLVDTHRADT LDELAEQLGI
PADALKKSVE KWNEACASGV DNEFGVLKEN LHPIDTPPYW GIRQWIRCSA INSGVMVNGN
CQVLDAQGNV IKGLYSVGSG AGNLCGGLEW NLAQGGLCCG SYMTMGRYAA IHAITGKMEP
SKPATYEDTK SYWAK
//
