ID C8X2N6_DESRD Unreviewed; 1159 AA.
AC C8X2N6;
DT 03-NOV-2009, integrated into UniProtKB/TrEMBL.
DT 03-NOV-2009, sequence version 1.
DT 27-MAR-2024, entry version 83.
DE RecName: Full=DNA polymerase III subunit alpha {ECO:0000256|ARBA:ARBA00019114};
DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
GN OrderedLocusNames=Dret_1396 {ECO:0000313|EMBL:ACV68683.1};
OS Desulfohalobium retbaense (strain ATCC 49708 / DSM 5692 / JCM 16813 /
OS HR100).
OC Bacteria; Thermodesulfobacteriota; Desulfovibrionia; Desulfovibrionales;
OC Desulfohalobiaceae; Desulfohalobium.
OX NCBI_TaxID=485915 {ECO:0000313|EMBL:ACV68683.1, ECO:0000313|Proteomes:UP000001052};
RN [1] {ECO:0000313|Proteomes:UP000001052}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 5692 {ECO:0000313|Proteomes:UP000001052};
RG US DOE Joint Genome Institute (JGI-PGF);
RA Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA Bruce D., Goodwin L., Pitluck S., Kyrpides N., Mavromatis K., Ivanova N.,
RA Mikhailova N., Munk A.C., Brettin T., Detter J.C., Han C., Tapia R.,
RA Larimer F., Land M., Hauser L., Markowitz V., Cheng J.-F., Hugenholtz P.,
RA Woyke T., Wu D., Spring S., Klenk H.-P., Eisen J.A.;
RT "The complete chromosome of Desulfohalobium retbaense DSM 5692.";
RL Submitted (SEP-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ACV68683.1, ECO:0000313|Proteomes:UP000001052}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 5692 {ECO:0000313|EMBL:ACV68683.1,
RC ECO:0000313|Proteomes:UP000001052};
RX PubMed=21304676;
RA Spring S., Nolan M., Lapidus A., Glavina Del Rio T., Copeland A., Tice H.,
RA Cheng J.F., Lucas S., Land M., Chen F., Bruce D., Goodwin L., Pitluck S.,
RA Ivanova N., Mavromatis K., Mikhailova N., Pati A., Chen A., Palaniappan K.,
RA Hauser L., Chang Y.J., Jeffries C.D., Munk C., Kiss H., Chain P., Han C.,
RA Brettin T., Detter J.C., Schuler E., Goker M., Rohde M., Bristow J.,
RA Eisen J.A., Markowitz V., Hugenholtz P., Kyrpides N.C., Klenk H.P.;
RT "Complete genome sequence of Desulfohalobium retbaense type strain
RT (HR(100)).";
RL Stand. Genomic Sci. 2:38-48(2010).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR EMBL; CP001734; ACV68683.1; -; Genomic_DNA.
DR RefSeq; WP_015751830.1; NC_013223.1.
DR AlphaFoldDB; C8X2N6; -.
DR STRING; 485915.Dret_1396; -.
DR KEGG; drt:Dret_1396; -.
DR eggNOG; COG0587; Bacteria.
DR HOGENOM; CLU_001600_0_0_7; -.
DR OrthoDB; 9803237at2; -.
DR Proteomes; UP000001052; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR CDD; cd04485; DnaE_OBF; 1.
DR CDD; cd12113; PHP_PolIIIA_DnaE3; 1.
DR Gene3D; 1.10.150.870; -; 1.
DR Gene3D; 1.10.10.1600; Bacterial DNA polymerase III alpha subunit, thumb domain; 1.
DR Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR InterPro; IPR011708; DNA_pol3_alpha_NTPase_dom.
DR InterPro; IPR041931; DNA_pol3_alpha_thumb_dom.
DR InterPro; IPR040982; DNA_pol3_finger.
DR InterPro; IPR004805; DnaE2/DnaE/PolC.
DR InterPro; IPR029460; DNAPol_HHH.
DR InterPro; IPR004365; NA-bd_OB_tRNA.
DR InterPro; IPR004013; PHP_dom.
DR InterPro; IPR003141; Pol/His_phosphatase_N.
DR InterPro; IPR016195; Pol/histidinol_Pase-like.
DR NCBIfam; TIGR00594; polc; 1.
DR PANTHER; PTHR32294; DNA POLYMERASE III SUBUNIT ALPHA; 1.
DR PANTHER; PTHR32294:SF0; DNA POLYMERASE III SUBUNIT ALPHA; 1.
DR Pfam; PF07733; DNA_pol3_alpha; 1.
DR Pfam; PF17657; DNA_pol3_finger; 1.
DR Pfam; PF14579; HHH_6; 1.
DR Pfam; PF02811; PHP; 1.
DR Pfam; PF01336; tRNA_anti-codon; 1.
DR SMART; SM00481; POLIIIAc; 1.
DR SUPFAM; SSF89550; PHP domain-like; 1.
PE 4: Predicted;
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Reference proteome {ECO:0000313|Proteomes:UP000001052};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 5..72
FT /note="Polymerase/histidinol phosphatase N-terminal"
FT /evidence="ECO:0000259|SMART:SM00481"
SQ SEQUENCE 1159 AA; 129257 MW; 7D14A209EA9687B0 CRC64;
MTDFTHLHCH TEYSLLDGAI RIGDLCQQAV DFGFSSVAIS DHGNLFGALD FYLTAKKFGV
KPIIGCEVYV APGDRRTKHT DKDIRSGYHL VLLAQNLTGY YNLVRLVSRG WLEGFHYKPR
VDKELLSQWN EGLIALSACL KGEVPYGLRH EGMSRGKALA EEYSALFPGR FYLELQANGI
PEQVTLNEQL LELAETTKLP LVATNDCHYL SYNDVEAHDI LLCIQTNAQY YAKDRMRFDT
QELYYRPPEE MEQAFAHCPQ ALENVGAIAR NCNVELDLGQ NYFPVYDVPQ GRTLEEEFIR
LVREGLRTRL AKLPYTVDEE VYWQRLDTEL DVICAKGFPA YFLIVQDFIN WAKEQGIPVG
PGRGSAAGSL VAYCLGITNL DPLRYNLLFE RFLNVERASM PDIDVDFCYN RREEVIRYVT
AKYGKESVAQ ITTFGTMKAK AVVRDVGRAL GLSFAETDKI AKLVPDDLKM TIDKALEQEP
DLAALAENDE TVAKLIDVSR RLEGLARHAS THAAGIVISD SHPLEDHLPL YLGKKGEVVT
QFDMKKVEKV GLIKFDFLGL KTLTVIADTL HLAQQAGKSV PDIDTLPLED EATFALLCRT
ETDGVFQLES SGMRNVIKDL QPTSFEDIIA LLALYRPGPL ESGMVTDFIR RKHGEIPVEY
PHPLLEPILE ATYGVILYQE QVMRIASDMA NYSLGDGDIL RRAMGKKDPS VMAEQRTKFV
NGAKENEIDE ATATYIFDLM EKFAGYGFNK SHSAAYALVS YQTAYLKAHY PVEFMAALIT
SEVSNTDKVI AHINACREMG IEVLPPDVNH SERHFTVENE KLRFGLSGVK NVGGGAIEAL
VAERRRNGPY ASLLDFCKRV GSRKVTKRVL ESLIKSGAMD SLGCSRASLL AALDKVVSTA
QRQSRDKSRG QLSLMAMMGE EDSCVLSGIG MDIEEAQVEE WDDEKRLQYE KEALGFFLSG
HPLLRFREEL KRQRLLSLQD CGELGGDTEV RTAVLVTGVK EHVTKKGGRM AFCQIEDLTG
TGEMTMFPET YAKVRNGLDL EQPLVVTAKI SSYEGGGNGD EGAKQIKLLA QEVGLLNDQV
GRGDEPVRVD IEAAALQGQS AQELKQIIGR YPGRAPVHLG VCLERADCVL QLGPNYRVAA
SPDFWREIRR WQSAHRPAS
//
