ID C8X4E0_DESRD Unreviewed; 919 AA.
AC C8X4E0;
DT 03-NOV-2009, integrated into UniProtKB/TrEMBL.
DT 03-NOV-2009, sequence version 1.
DT 27-MAR-2024, entry version 89.
DE RecName: Full=UvrABC system protein A {ECO:0000256|ARBA:ARBA00039316};
DE AltName: Full=Excinuclease ABC subunit A {ECO:0000256|ARBA:ARBA00042156};
GN OrderedLocusNames=Dret_2130 {ECO:0000313|EMBL:ACV69414.1};
OS Desulfohalobium retbaense (strain ATCC 49708 / DSM 5692 / JCM 16813 /
OS HR100).
OC Bacteria; Thermodesulfobacteriota; Desulfovibrionia; Desulfovibrionales;
OC Desulfohalobiaceae; Desulfohalobium.
OX NCBI_TaxID=485915 {ECO:0000313|EMBL:ACV69414.1, ECO:0000313|Proteomes:UP000001052};
RN [1] {ECO:0000313|Proteomes:UP000001052}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 5692 {ECO:0000313|Proteomes:UP000001052};
RG US DOE Joint Genome Institute (JGI-PGF);
RA Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA Bruce D., Goodwin L., Pitluck S., Kyrpides N., Mavromatis K., Ivanova N.,
RA Mikhailova N., Munk A.C., Brettin T., Detter J.C., Han C., Tapia R.,
RA Larimer F., Land M., Hauser L., Markowitz V., Cheng J.-F., Hugenholtz P.,
RA Woyke T., Wu D., Spring S., Klenk H.-P., Eisen J.A.;
RT "The complete chromosome of Desulfohalobium retbaense DSM 5692.";
RL Submitted (SEP-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ACV69414.1, ECO:0000313|Proteomes:UP000001052}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 5692 {ECO:0000313|EMBL:ACV69414.1,
RC ECO:0000313|Proteomes:UP000001052};
RX PubMed=21304676;
RA Spring S., Nolan M., Lapidus A., Glavina Del Rio T., Copeland A., Tice H.,
RA Cheng J.F., Lucas S., Land M., Chen F., Bruce D., Goodwin L., Pitluck S.,
RA Ivanova N., Mavromatis K., Mikhailova N., Pati A., Chen A., Palaniappan K.,
RA Hauser L., Chang Y.J., Jeffries C.D., Munk C., Kiss H., Chain P., Han C.,
RA Brettin T., Detter J.C., Schuler E., Goker M., Rohde M., Bristow J.,
RA Eisen J.A., Markowitz V., Hugenholtz P., Kyrpides N.C., Klenk H.P.;
RT "Complete genome sequence of Desulfohalobium retbaense type strain
RT (HR(100)).";
RL Stand. Genomic Sci. 2:38-48(2010).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. UvrA family.
CC {ECO:0000256|ARBA:ARBA00038000}.
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DR EMBL; CP001734; ACV69414.1; -; Genomic_DNA.
DR RefSeq; WP_015752555.1; NC_013223.1.
DR AlphaFoldDB; C8X4E0; -.
DR STRING; 485915.Dret_2130; -.
DR KEGG; drt:Dret_2130; -.
DR eggNOG; COG0178; Bacteria.
DR HOGENOM; CLU_001370_0_2_7; -.
DR OrthoDB; 9809851at2; -.
DR Proteomes; UP000001052; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004518; F:nuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:InterPro.
DR Gene3D; 3.30.190.20; -; 1.
DR Gene3D; 1.10.8.280; ABC transporter ATPase domain-like; 2.
DR Gene3D; 1.20.1580.10; ABC transporter ATPase like domain; 3.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR004602; UvrA.
DR InterPro; IPR041552; UvrA_DNA-bd.
DR InterPro; IPR041102; UvrA_inter.
DR NCBIfam; TIGR00630; uvra; 1.
DR PANTHER; PTHR43152; UVRABC SYSTEM PROTEIN A; 1.
DR PANTHER; PTHR43152:SF3; UVRABC SYSTEM PROTEIN A; 1.
DR Pfam; PF17755; UvrA_DNA-bind; 1.
DR Pfam; PF17760; UvrA_inter; 1.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 2.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA excision {ECO:0000256|ARBA:ARBA00022769};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Excision nuclease {ECO:0000256|ARBA:ARBA00022881};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000001052};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 583..914
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
SQ SEQUENCE 919 AA; 100437 MW; 37B68F8DFE843E71 CRC64;
MQTSISISGA KQHNLKNLDL DIPRDQLVVV CGPSGSGKST LAFDIVYAEG QRRYVESLST
YARQFLPQLD KPKVDKVEGL SPAISLEQHT SSRNPRSTVG TVTELYDFLR VFFARLGVPY
CPQCGKPIAA QSSDEIIDDI MALQERTKFM LLAPLVEHKK GTQAELFKKL KGQGFVRVRV
DGEVVPLDPA PQLEKNKRHT LELVVDRLVM KQGLRSRLAD SVELALQFGE GRLILDIIGD
EEKLYSTEAV CPSCNISLPK PSPQLFSFNS PQGACPTCSG LGALDYFEPR LLAPNKGLSL
NGGGIIPWKN PRVLARFADD LHALGHRYGF DLDTALGNFS EQAWQALFYG DEATGWPGAI
SHLEAGMGLG RFWRDEMARF RQSAPCPACH GARLKPESLA VRVEGVNIQD FTTWSIAHAL
EWLEGLRFTG FQKTIGDPLL QELTHRLRFL ADVGLDYLNL ARNMSTLSGG EAQRIRLAGQ
LGSGLVGVTY VLDEPSIGLH PRDNARLIRT LRQLQQRGNT VLVVEHDRPT IEAADHVLEL
GPGSGALGGE IIYSGGVEGL RQAPDSLTGK YLRGELAIEP PATRREPTSM LHLQGVRTNN
LQNLECSLPL GNLVCITGVS GSGKSSLVVD SLYKHLALAQ GIKVENPGQI DNISGTEAVE
KVIPIDQSPI GRTPRSNPAT YTKVFDEIRK IFAATPEAKK RGYKPGRFSF NVRGGRCEAC
QGDGQIRVEM HFLPDVFVTC EVCGGKRYNR ETLEVRYKDL DISEVLGLSV RQARALFSNY
PVLDRKLGVL EEVGLEYLAL GQPATTLSGG EAQRLKISRE LGKRSLPGTL YILDEPTTGL
HMHEVGKLIQ VLHKLVDKGA SVMVIEHNTD VIKAADHVID LGPGGGEFGG LIVASGTPEE
IRDNPQSVTG EFLRNGRTG
//
