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Database: UniProt
Entry: C8ZCR2
LinkDB: C8ZCR2
Original site: C8ZCR2 
ID   NFT1_YEAS8              Reviewed;        1558 AA.
AC   C8ZCR2; C8ZCR3;
DT   23-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT   03-NOV-2009, sequence version 1.
DT   16-JAN-2019, entry version 39.
DE   RecName: Full=ABC transporter NFT1;
DE   AltName: Full=New full-length MRP-type transporter 1;
GN   Name=NFT1; ORFNames=EC1118_1K5_3730g, EC1118_1K5_3741p;
OS   Saccharomyces cerevisiae (strain Lalvin EC1118 / Prise de mousse)
OS   (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
OC   Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=643680;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Lalvin EC1118 / Prise de mousse;
RX   PubMed=19805302; DOI=10.1073/pnas.0904673106;
RA   Novo M., Bigey F., Beyne E., Galeote V., Gavory F., Mallet S.,
RA   Cambon B., Legras J.-L., Wincker P., Casaregola S., Dequin S.;
RT   "Eukaryote-to-eukaryote gene transfer events revealed by the genome
RT   sequence of the wine yeast Saccharomyces cerevisiae EC1118.";
RL   Proc. Natl. Acad. Sci. U.S.A. 106:16333-16338(2009).
CC   -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCC
CC       family. Conjugate transporter (TC 3.A.1.208) subfamily.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAY81179.1; Type=Erroneous initiation; Evidence={ECO:0000305};
DR   EMBL; FN393077; CAY81178.1; -; Genomic_DNA.
DR   EMBL; FN393077; CAY81179.1; ALT_INIT; Genomic_DNA.
DR   PRIDE; C8ZCR2; -.
DR   EnsemblFungi; CAY81178; CAY81178; EC1118_1K5_3730g.
DR   EnsemblFungi; CAY81179; CAY81179; EC1118_1K5_3741g.
DR   Proteomes; UP000000286; Chromosome XI, Scaffold EC1118_1K5.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0042626; F:ATPase activity, coupled to transmembrane movement of substances; IEA:InterPro.
DR   Gene3D; 1.20.1560.10; -; 2.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR011527; ABC1_TM_dom.
DR   InterPro; IPR036640; ABC1_TM_sf.
DR   InterPro; IPR003439; ABC_transporter-like.
DR   InterPro; IPR017871; ABC_transporter_CS.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF00664; ABC_membrane; 2.
DR   Pfam; PF00005; ABC_tran; 2.
DR   SMART; SM00382; AAA; 2.
DR   SUPFAM; SSF52540; SSF52540; 2.
DR   SUPFAM; SSF90123; SSF90123; 2.
DR   PROSITE; PS50929; ABC_TM1F; 2.
DR   PROSITE; PS00211; ABC_TRANSPORTER_1; 2.
DR   PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Glycoprotein; Membrane;
KW   Nucleotide-binding; Repeat; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN         1   1558       ABC transporter NFT1.
FT                                /FTId=PRO_0000392616.
FT   TOPO_DOM      1     29       Extracellular. {ECO:0000255}.
FT   TRANSMEM     30     50       Helical. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00441}.
FT   TOPO_DOM     51    103       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM    104    124       Helical. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00441}.
FT   TOPO_DOM    125    130       Extracellular. {ECO:0000255}.
FT   TRANSMEM    131    151       Helical. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00441}.
FT   TOPO_DOM    152    169       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM    170    190       Helical. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00441}.
FT   TOPO_DOM    191    201       Extracellular. {ECO:0000255}.
FT   TRANSMEM    202    222       Helical. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00441}.
FT   TOPO_DOM    223    302       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM    303    323       Helical. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00441}.
FT   TOPO_DOM    324    351       Extracellular. {ECO:0000255}.
FT   TRANSMEM    352    374       Helical. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00441}.
FT   TOPO_DOM    375    449       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM    450    470       Helical. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00441}.
FT   TOPO_DOM    471    481       Extracellular. {ECO:0000255}.
FT   TRANSMEM    482    504       Helical. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00441}.
FT   TOPO_DOM    505    558       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM    559    579       Helical. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00441}.
FT   TOPO_DOM    580    584       Extracellular. {ECO:0000255}.
FT   TRANSMEM    585    605       Helical. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00441}.
FT   TOPO_DOM    606    953       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM    954    974       Helical. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00441}.
FT   TOPO_DOM    975   1013       Extracellular. {ECO:0000255}.
FT   TRANSMEM   1014   1034       Helical. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00441}.
FT   TOPO_DOM   1035   1082       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM   1083   1105       Helical. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00441}.
FT   TOPO_DOM   1106   1109       Extracellular. {ECO:0000255}.
FT   TRANSMEM   1110   1132       Helical. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00441}.
FT   TOPO_DOM   1133   1199       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM   1200   1220       Helical. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00441}.
FT   TOPO_DOM   1221   1222       Extracellular. {ECO:0000255}.
FT   TRANSMEM   1223   1243       Helical. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00441}.
FT   TOPO_DOM   1244   1558       Cytoplasmic. {ECO:0000255}.
FT   DOMAIN      311    621       ABC transmembrane type-1 1.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00441}.
FT   DOMAIN      651    892       ABC transporter 1. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00434}.
FT   DOMAIN      961   1251       ABC transmembrane type-1 2.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00441}.
FT   DOMAIN     1285   1538       ABC transporter 2. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00434}.
FT   NP_BIND     686    693       ATP. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00434}.
FT   NP_BIND    1319   1326       ATP. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00434}.
FT   CARBOHYD      4      4       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
SQ   SEQUENCE   1558 AA;  176347 MW;  6E0619F4DD96C731 CRC64;
     MIKNGTCPYW ERDDLSECAR REYIEFKFPL FILLTGMIYA FCKVFRAFYL RGKNHTNEAP
     EFEEQGNGNH EYARFSVLRL KSAWESRSFC NVNNRSTFDK FKKFIEGAFI VLQLTIHLYI
     LSSMLMDNKK FFHQGFLVQM FLWILLLVVI TLRLISASQS FRWVLACKRD LWAVSFYSYA
     SLFTLSILPL RSVFIGKIKD KIMVKYIISE TFIDLALLLL LSTSSIEGTR YSFLVENENK
     KLPPAPTVFG LLTFSRIDRL IWKAYKHCLG NADIWDLDIN NKSIAILANF EMSSKKGRLL
     PNIICYFKAV FISQLFLAFV SSFLNFVPSL LMPRILSYVN DPKSKSWNLV SLYVSSMLVS
     KIIATTCRGQ GLFLGEKGTM QLRTVLISNI YSKTLRRTIL KDSTTSLQKN ASTSFEENPD
     SSEAEPRKKS SRKDNSVNNV MSIDAFKVSE AMNTFYLACE AVFMTVTALM ILYSLLGWSA
     FAGTFALLAM IPLNFWCATF YGNYQADQLI LTDKRTSGIS EALNSIRVIK LLAWENLFYQ
     KIINVRDGEI RLLKKKATIF FLNHLIWFFG PTLVSAITFS VFIKFQNQTL TPTIAFTALS
     LFAILRTPMD QIASTVSLLI QSFISLERIQ DYLNESETRK YEILEQSNTK FGFEDASMEW
     EAAETSFKLK NISIDFKLNS LNAIIGPTGS GKSSLLLGLL GELNLLSGKI YVPTVESRDD
     LEIGKDGMTN SMAYCSQTPW LISGTIKDNV VFGEIFNKQK FDDVMKSCCL DKDIKAMTAG
     IRTDVGDGGF SLSGGQQQRI ALARAIYSSS RYLILDDCLS AVDPETALYI YEECLCGPMM
     KGRTCIITSH NISLVTKRAD WLVLLDRGEV KSQGKPSDLI KSNEFLRESI NNDSKNTTHN
     QIDLKRSTTS KKTKNGDPEG GNSQDEVCAE VENFEETKME GSVKFSAYKW LADYFGGLGV
     VFVFTSSSIL IHGITLSQGF WLRYWLDTGS SGSKSTWLYR IVEGHSNIYF LLTYIIIGLV
     SSFLTSGKVW IAIISGTNVT KKIFAKLLSS ILYAKLRFHN VTPTGRIMNR FSKDMDIIDQ
     QLIPNFEGLS YSVVVCLWII LLIGYVTPQF LLFAIPLCAL YYTVCTLYLR ASRELKRIDN
     INISPIHQLF AEAIKGVTTI RALADERRFI TQSLVAIDRS NAPFFYLNMA TEWITYRVDI
     IGTLVLFSSS VMIIMKASYL DAGLAGILLS NAFSFTETAQ WIIKVFSSVE LLMSSVERIK
     EYTDIPSESN GYISPPANWP QTGDVELKNL SLRYSPHSSK ALDNVSFKVK AGTKVGIVGR
     TGAGKSSIIA AIYRLSDWEN GTITIDNKDI KHIPLERLRN SISCIPQDPT LFDGTVRSNL
     DPFDRYSDVQ IYGVLSKVGL IEECDELCLI FEQEQPNFSS HKLRNRFIDL NTVVKSGGSN
     LSQGQRQLLC LARSMLGARN IMLIDEATAS IDYISDAKIQ KTIRETMKNT TILTIAHRLR
     SVIDYDKILV MEMGRVKEYD HPYTLISDRN TIFYRLCRQS GEFENLFELA KVSFDNKR
//
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