ID C9IZC7_HUMAN Unreviewed; 70 AA.
AC C9IZC7;
DT 03-NOV-2009, integrated into UniProtKB/TrEMBL.
DT 03-NOV-2009, sequence version 1.
DT 27-MAR-2024, entry version 87.
DE SubName: Full=Islet cell autoantigen 1 {ECO:0000313|Ensembl:ENSP00000406722.1};
DE Flags: Fragment;
GN Name=ICA1 {ECO:0000313|Ensembl:ENSP00000406722.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000406722.1, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000406722.1, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12853948; DOI=10.1038/nature01782;
RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA Wilson R.K.;
RT "The DNA sequence of human chromosome 7.";
RL Nature 424:157-164(2003).
RN [2] {ECO:0000313|Ensembl:ENSP00000406722.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AC006042; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC007009; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; C9IZC7; -.
DR MassIVE; C9IZC7; -.
DR MaxQB; C9IZC7; -.
DR PeptideAtlas; C9IZC7; -.
DR ProteomicsDB; 7781; -.
DR Antibodypedia; 1895; 282 antibodies from 28 providers.
DR Ensembl; ENST00000446305.1; ENSP00000406722.1; ENSG00000003147.19.
DR UCSC; uc064bmq.1; human.
DR HGNC; HGNC:5343; ICA1.
DR VEuPathDB; HostDB:ENSG00000003147; -.
DR GeneTree; ENSGT00390000005530; -.
DR HOGENOM; CLU_172933_0_0_1; -.
DR ChiTaRS; ICA1; human.
DR Proteomes; UP000005640; Chromosome 7.
DR Bgee; ENSG00000003147; Expressed in body of pancreas and 183 other cell types or tissues.
DR ExpressionAtlas; C9IZC7; baseline and differential.
DR GO; GO:0019904; F:protein domain specific binding; IEA:InterPro.
DR InterPro; IPR010504; AH_dom.
DR InterPro; IPR024114; Islet_autoAg_Ica1/Ica1-like.
DR PANTHER; PTHR10164; ISLET CELL AUTOANTIGEN 1; 1.
DR PANTHER; PTHR10164:SF3; ISLET CELL AUTOANTIGEN 1; 1.
DR Pfam; PF06456; Arfaptin; 1.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|EPD:C9IZC7,
KW ECO:0007829|MaxQB:C9IZC7};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640}.
FT DOMAIN 21..69
FT /note="AH"
FT /evidence="ECO:0000259|Pfam:PF06456"
FT NON_TER 70
FT /evidence="ECO:0000313|Ensembl:ENSP00000406722.1"
SQ SEQUENCE 70 AA; 8203 MW; DEECA7E1B8001E19 CRC64;
MSGHKCYPWD LQDRYAQDKS VVNKMQQKYW ETKQAFIKAT GKKEDEHVVA SDADLDAKLE
LFHSIQRTCL
//
