ID C9J088_HUMAN Unreviewed; 658 AA.
AC C9J088;
DT 03-NOV-2009, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 2.
DT 27-MAR-2024, entry version 78.
DE RecName: Full=Transcription initiation factor TFIID subunit 6 {ECO:0000256|ARBA:ARBA00040091};
GN Name=TAF6 {ECO:0000313|Ensembl:ENSP00000412346.3};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000412346.3, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000412346.3, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12853948; DOI=10.1038/nature01782;
RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA Wilson R.K.;
RT "The DNA sequence of human chromosome 7.";
RL Nature 424:157-164(2003).
RN [2] {ECO:0007829|PubMed:21269460}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Burckstummer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [3] {ECO:0007829|PubMed:23186163}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=23186163;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
RN [4] {ECO:0000313|Ensembl:ENSP00000412346.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the TAF6 family.
CC {ECO:0000256|ARBA:ARBA00007688}.
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DR EMBL; AC073842; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR ProteomicsDB; 7905; -.
DR Antibodypedia; 1765; 223 antibodies from 24 providers.
DR Ensembl; ENST00000452438.7; ENSP00000412346.3; ENSG00000106290.16.
DR Ensembl; ENST00000687216.1; ENSP00000509789.1; ENSG00000106290.16.
DR Ensembl; ENST00000688086.1; ENSP00000510349.1; ENSG00000106290.16.
DR Ensembl; ENST00000689284.1; ENSP00000509292.1; ENSG00000106290.16.
DR Ensembl; ENST00000691413.1; ENSP00000509680.1; ENSG00000106290.16.
DR Ensembl; ENST00000693225.1; ENSP00000510019.1; ENSG00000106290.16.
DR UCSC; uc064gad.1; human.
DR HGNC; HGNC:11540; TAF6.
DR VEuPathDB; HostDB:ENSG00000106290; -.
DR GeneTree; ENSGT00640000091486; -.
DR ChiTaRS; TAF6; human.
DR Proteomes; UP000005640; Chromosome 7.
DR Bgee; ENSG00000106290; Expressed in stromal cell of endometrium and 206 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IDA:HPA.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR GO; GO:0000124; C:SAGA complex; IEA:InterPro.
DR GO; GO:0046695; C:SLIK (SAGA-like) complex; IEA:InterPro.
DR GO; GO:0005669; C:transcription factor TFIID complex; IEA:InterPro.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR GO; GO:0016251; F:RNA polymerase II general transcription initiation factor activity; IEA:InterPro.
DR GO; GO:0006367; P:transcription initiation at RNA polymerase II promoter; IEA:InterPro.
DR CDD; cd08050; TAF6C; 1.
DR Gene3D; 1.10.20.10; Histone, subunit A; 1.
DR Gene3D; 1.25.40.770; TAF6, C-terminal HEAT repeat domain; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR009072; Histone-fold.
DR InterPro; IPR037796; TAF6.
DR InterPro; IPR011442; TAF6_C.
DR InterPro; IPR046344; TAF6_C_sf.
DR InterPro; IPR004823; TAF_TATA-bd_Histone-like_dom.
DR PANTHER; PTHR10221; TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 6; 1.
DR PANTHER; PTHR10221:SF9; TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 6; 1.
DR Pfam; PF02969; TAF; 1.
DR Pfam; PF07571; TAF6_C; 1.
DR SMART; SM00803; TAF; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF47113; Histone-fold; 1.
PE 1: Evidence at protein level;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Proteomics identification {ECO:0007829|EPD:C9J088,
KW ECO:0007829|MaxQB:C9J088};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 12..78
FT /note="TATA box binding protein associated factor (TAF)
FT histone-like fold"
FT /evidence="ECO:0000259|SMART:SM00803"
FT REGION 136..182
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 505..555
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 592..658
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 136..157
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 518..555
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 658 AA; 70630 MW; DE471AD1F02FCCAF CRC64;
MAEEKKLKLS NTVLPSESMK VVAESMGIAQ IQEETCQLLT DEVSYRIKEI AQDALKFMHM
GKRQKLTTSD IDYALKLKNV EPLYGFHAQE FIPFRFASGG GRELYFYEEK EVDLSDIINT
PLPRVPLDVC LKAPKEQQKA EATEPLKSAK PGQEEDGPLK GKGQGATTAD GKGKEKKAPP
LLEGAPLRLK PRSIHELSVE QQLYYKEITE ACVGSCEAKR AEALQSIATD PGLYQMLPRF
STFISEGVRV NVVQNNLALL IYLMRMVKAL MDNPTLYLEK YVHELIPAVM TCIVSRQLCL
RPDVDNHWAL RDFAARLVAQ ICKHFSTTTN NIQSRITKTF TKSWVDEKTP WTTRYGSIAG
LAELGHDVIK TLILPRLQQE GERIRSVLDG PVLSNIDRIG ADHVQSLLLK HCAPVLAKLR
PPPDNQDAYR AEFGSLGPLL CSQVVKARAQ AALQAQQVNR TTLTITQPRP TLTLSQAPQP
GPRTPGLLKV PGSIALPVQT LVSARAAAPP QPSPPPTKFI VMSSSSSAPS TQQVLSLSTS
APGSGSTTTS PVTTTVPSVQ PIVKLVSTAT TAPPSTAPSG PGSVQKYIVV SLPPTGEGKG
GPTSHPSPVP PPASSPSPLS GSALCGGKQE AGDSPPPAPG TPKANGSQPN SGSPQPAP
//
