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Database: UniProt
Entry: C9JKQ7_HUMAN
LinkDB: C9JKQ7_HUMAN
Original site: C9JKQ7_HUMAN 
ID   C9JKQ7_HUMAN            Unreviewed;       138 AA.
AC   C9JKQ7;
DT   03-NOV-2009, integrated into UniProtKB/TrEMBL.
DT   03-NOV-2009, sequence version 1.
DT   08-MAY-2019, entry version 70.
DE   SubName: Full=Trifunctional purine biosynthetic protein adenosine-3 {ECO:0000313|Ensembl:ENSP00000413803};
DE   Flags: Fragment;
GN   Name=GART {ECO:0000313|Ensembl:ENSP00000413803};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000413803, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000413803, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=10830953; DOI=10.1038/35012518;
RG   Chromosome 21 mapping and sequencing consortium;
RA   Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T.,
RA   Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y.,
RA   Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K.,
RA   Polley A., Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D.,
RA   Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W.,
RA   Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S.,
RA   Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E.,
RA   Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P.,
RA   Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H.,
RA   Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E.,
RA   Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F.,
RA   Lehrach H., Reinhardt R., Yaspo M.-L.;
RT   "The DNA sequence of human chromosome 21.";
RL   Nature 405:311-319(2000).
RN   [2] {ECO:0000213|PubMed:19413330}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=19413330; DOI=10.1021/ac9004309;
RA   Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,
RA   Mohammed S.;
RT   "Lys-N and trypsin cover complementary parts of the phosphoproteome in
RT   a refined SCX-based approach.";
RL   Anal. Chem. 81:4493-4501(2009).
RN   [3] {ECO:0000213|PubMed:21269460}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA   Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA   Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT   "Initial characterization of the human central proteome.";
RL   BMC Syst. Biol. 5:17-17(2011).
RN   [4] {ECO:0000313|Ensembl:ENSP00000413803}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
RN   [5] {ECO:0000213|PubMed:23186163}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=23186163;
RA   Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA   Mohammed S.;
RT   "Toward a comprehensive characterization of a human cancer cell
RT   phosphoproteome.";
RL   J. Proteome Res. 12:260-271(2013).
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DR   EMBL; AP000302; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AP000303; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF457223; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF511397; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EPD; C9JKQ7; -.
DR   jPOST; C9JKQ7; -.
DR   MaxQB; C9JKQ7; -.
DR   PeptideAtlas; C9JKQ7; -.
DR   PRIDE; C9JKQ7; -.
DR   Ensembl; ENST00000438059; ENSP00000413803; ENSG00000159131.
DR   UCSC; uc061zrb.1; human.
DR   HGNC; HGNC:4163; GART.
DR   OpenTargets; ENSG00000159131; -.
DR   eggNOG; KOG0237; Eukaryota.
DR   eggNOG; KOG3076; Eukaryota.
DR   eggNOG; COG0150; LUCA.
DR   eggNOG; COG0151; LUCA.
DR   eggNOG; COG0299; LUCA.
DR   GeneTree; ENSGT00390000000292; -.
DR   HOGENOM; HOG000033463; -.
DR   ChiTaRS; GART; human.
DR   Proteomes; UP000005640; Chromosome 21.
DR   Bgee; ENSG00000159131; Expressed in 218 organ(s), highest expression level in lung.
DR   ExpressionAtlas; C9JKQ7; baseline and differential.
DR   GO; GO:0004637; F:phosphoribosylamine-glycine ligase activity; IEA:InterPro.
DR   GO; GO:0004641; F:phosphoribosylformylglycinamidine cyclo-ligase activity; IEA:InterPro.
DR   GO; GO:0006189; P:'de novo' IMP biosynthetic process; IEA:InterPro.
DR   GO; GO:0009113; P:purine nucleobase biosynthetic process; IEA:InterPro.
DR   InterPro; IPR016185; PreATP-grasp_dom_sf.
DR   InterPro; IPR020561; PRibGlycinamid_synth_ATP-grasp.
DR   InterPro; IPR020562; PRibGlycinamide_synth_N.
DR   Pfam; PF01071; GARS_A; 1.
DR   Pfam; PF02844; GARS_N; 1.
DR   SUPFAM; SSF52440; SSF52440; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|EPD:C9JKQ7,
KW   ECO:0000213|MaxQB:C9JKQ7, ECO:0000213|PeptideAtlas:C9JKQ7};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640}.
FT   DOMAIN        4    104       GARS_N. {ECO:0000259|Pfam:PF02844}.
FT   DOMAIN      105    137       GARS_A. {ECO:0000259|Pfam:PF01071}.
FT   NON_TER     138    138       {ECO:0000313|Ensembl:ENSP00000413803}.
SQ   SEQUENCE   138 AA;  14687 MW;  4AC3990133CADB5F CRC64;
     MAARVLIIGS GGREHTLAWK LAQSHHVKQV LVAPGNAGTA CSEKISNTAI SISDHTALAQ
     FCKEKKIEFV VVGPEAPLAA GIVGNLRSAG VQCFGPTAEA AQLESSKRFA KEFMDRHGIP
     TAQWKAFTKP EEACSFIL
//
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