ID C9JLT6_HUMAN Unreviewed; 155 AA.
AC C9JLT6;
DT 03-NOV-2009, integrated into UniProtKB/TrEMBL.
DT 03-NOV-2009, sequence version 1.
DT 27-MAR-2024, entry version 73.
DE SubName: Full=Growth factor receptor bound protein 14 {ECO:0000313|Ensembl:ENSP00000401702.1};
DE Flags: Fragment;
GN Name=GRB14 {ECO:0000313|Ensembl:ENSP00000401702.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000401702.1, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000401702.1, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [2] {ECO:0000313|Ensembl:ENSP00000401702.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AC107075; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC110086; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; C9JLT6; -.
DR SMR; C9JLT6; -.
DR MassIVE; C9JLT6; -.
DR MaxQB; C9JLT6; -.
DR PeptideAtlas; C9JLT6; -.
DR ProteomicsDB; 10749; -.
DR Antibodypedia; 33757; 215 antibodies from 29 providers.
DR Ensembl; ENST00000424693.1; ENSP00000401702.1; ENSG00000115290.11.
DR UCSC; uc061pbt.1; human.
DR HGNC; HGNC:4565; GRB14.
DR VEuPathDB; HostDB:ENSG00000115290; -.
DR GeneTree; ENSGT00940000158609; -.
DR HOGENOM; CLU_1699521_0_0_1; -.
DR ChiTaRS; GRB14; human.
DR Proteomes; UP000005640; Chromosome 2.
DR Bgee; ENSG00000115290; Expressed in adrenal tissue and 132 other cell types or tissues.
DR ExpressionAtlas; C9JLT6; baseline and differential.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd16139; RA_GRB14; 1.
DR InterPro; IPR039664; GRB/APBB1IP.
DR InterPro; IPR000159; RA_dom.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR11243; GROWTH FACTOR RECEPTOR-BOUND PROTEIN; 1.
DR PANTHER; PTHR11243:SF22; GROWTH FACTOR RECEPTOR-BOUND PROTEIN 14; 1.
DR Pfam; PF00788; RA; 1.
DR SMART; SM00314; RA; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50200; RA; 1.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|PeptideAtlas:C9JLT6,
KW ECO:0007829|ProteomicsDB:C9JLT6};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640}.
FT DOMAIN 48..134
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
FT NON_TER 155
FT /evidence="ECO:0000313|Ensembl:ENSP00000401702.1"
SQ SEQUENCE 155 AA; 18298 MW; E37A155C56BCC4F1 CRC64;
MFSYCRRKKK DLDVPEMPSI PNPFPELCCS PFTSVLSADL FPKANSRKKQ VIKVYSEDET
SRALDVPSDI TARDVCQLLI LKNHYIDDHS WTLFEHLPHI GVERTIEDHE LVIEVLSNWG
IEEENKLYFR KNYAKYEFFK NPMYFFPEHM VSFAT
//
