ID C9K0I4_HUMAN Unreviewed; 81 AA.
AC C9K0I4;
DT 03-NOV-2009, integrated into UniProtKB/TrEMBL.
DT 03-NOV-2009, sequence version 1.
DT 27-MAR-2024, entry version 97.
DE RecName: Full=Transmembrane protein 50B {ECO:0000256|ARBA:ARBA00041170};
DE Flags: Fragment;
GN Name=TMEM50B {ECO:0000313|Ensembl:ENSP00000387622.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000387622.1, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000387622.1, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=10830953; DOI=10.1038/35012518;
RG Chromosome 21 mapping and sequencing consortium;
RA Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S.,
RA Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M.,
RA Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A., Menzel U.,
RA Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A.,
RA Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J.,
RA Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K.,
RA Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G.,
RA Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J.,
RA Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S.,
RA Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K.,
RA Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.;
RT "The DNA sequence of human chromosome 21.";
RL Nature 405:311-319(2000).
RN [2] {ECO:0007829|PubMed:22223895}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22223895; DOI=10.1074/mcp.M111.015131;
RA Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T.,
RA Giglione C.;
RT "Comparative large-scale characterisation of plant vs. mammal proteins
RT reveals similar and idiosyncratic N-alpha acetylation features.";
RL Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012).
RN [3] {ECO:0000313|Ensembl:ENSP00000387622.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBUNIT: May form homotrimers or homodimers.
CC {ECO:0000256|ARBA:ARBA00038714}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004477}. Golgi apparatus membrane
CC {ECO:0000256|ARBA:ARBA00004653}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004653}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the UPF0220 family.
CC {ECO:0000256|ARBA:ARBA00005335}.
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DR EMBL; AC207981; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AP000300; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AP000301; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AP000302; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR ProteomicsDB; 12552; -.
DR Antibodypedia; 42040; 41 antibodies from 18 providers.
DR Ensembl; ENST00000432504.1; ENSP00000387622.1; ENSG00000142188.17.
DR Ensembl; ENST00000574612.1; ENSP00000459785.1; ENSG00000263160.6.
DR UCSC; uc061zqk.1; human.
DR HGNC; HGNC:1280; TMEM50B.
DR VEuPathDB; HostDB:ENSG00000142188; -.
DR GeneTree; ENSGT00940000155131; -.
DR HOGENOM; CLU_2415301_0_0_1; -.
DR OMA; LWIMFAD; -.
DR ChiTaRS; TMEM50B; human.
DR Proteomes; UP000005640; Chromosome 21.
DR Bgee; ENSG00000142188; Expressed in right lobe of thyroid gland and 95 other cell types or tissues.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR007919; UPF0220.
DR PANTHER; PTHR13180; SMALL MEMBRANE PROTEIN-RELATED; 1.
DR PANTHER; PTHR13180:SF2; TRANSMEMBRANE PROTEIN 50B; 1.
DR Pfam; PF05255; UPF0220; 1.
PE 1: Evidence at protein level;
KW Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Proteomics identification {ECO:0007829|EPD:C9K0I4,
KW ECO:0007829|MaxQB:C9K0I4};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 24..42
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 54..75
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT NON_TER 81
FT /evidence="ECO:0000313|Ensembl:ENSP00000387622.1"
SQ SEQUENCE 81 AA; 9216 MW; 7AD921C90E76A274 CRC64;
MAGFLDNFRW PECECIDWSE RRNAVASVVA GILFFTGWWI MIDAAVVYPK PEQLNHAFHT
CGVFSTLAFF MINAVSNAQV R
//
