ID C9KQK7_9FIRM Unreviewed; 781 AA.
AC C9KQK7;
DT 24-NOV-2009, integrated into UniProtKB/TrEMBL.
DT 24-NOV-2009, sequence version 1.
DT 18-JUN-2025, entry version 67.
DE RecName: Full=Ferrous iron transport protein B {ECO:0000256|NCBIfam:TIGR00437, ECO:0000256|RuleBase:RU362098};
GN Name=feoB {ECO:0000313|EMBL:EEX67783.1};
GN ORFNames=MITSMUL_05526 {ECO:0000313|EMBL:EEX67783.1};
OS Mitsuokella multacida DSM 20544.
OC Bacteria; Bacillati; Bacillota; Negativicutes; Selenomonadales;
OC Selenomonadaceae; Mitsuokella.
OX NCBI_TaxID=500635 {ECO:0000313|EMBL:EEX67783.1, ECO:0000313|Proteomes:UP000003671};
RN [1] {ECO:0000313|EMBL:EEX67783.1, ECO:0000313|Proteomes:UP000003671}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 20544 {ECO:0000313|EMBL:EEX67783.1,
RC ECO:0000313|Proteomes:UP000003671};
RA Weinstock G., Sodergren E., Clifton S., Fulton L., Fulton B., Courtney L.,
RA Fronick C., Harrison M., Strong C., Farmer C., Delahaunty K., Markovic C.,
RA Hall O., Minx P., Tomlinson C., Mitreva M., Nelson J., Hou S., Wollam A.,
RA Pepin K.H., Johnson M., Bhonagiri V., Nash W.E., Warren W., Chinwalla A.,
RA Mardis E.R., Wilson R.K.;
RL Submitted (SEP-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Probable transporter of a GTP-driven Fe(2+) uptake system.
CC {ECO:0000256|ARBA:ARBA00003926, ECO:0000256|RuleBase:RU362098}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|ARBA:ARBA00004429}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004429}. Cell membrane
CC {ECO:0000256|RuleBase:RU362098}; Multi-pass membrane protein
CC {ECO:0000256|RuleBase:RU362098}.
CC -!- SIMILARITY: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like
CC GTPase superfamily. FeoB GTPase (TC 9.A.8) family.
CC {ECO:0000256|RuleBase:RU362098}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EEX67783.1}.
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DR EMBL; ABWK02000025; EEX67783.1; -; Genomic_DNA.
DR RefSeq; WP_005842873.1; NZ_GG697143.2.
DR AlphaFoldDB; C9KQK7; -.
DR STRING; 500635.MITSMUL_05526; -.
DR GeneID; 93482406; -.
DR PATRIC; fig|500635.8.peg.2127; -.
DR eggNOG; COG0370; Bacteria.
DR HOGENOM; CLU_013350_3_0_9; -.
DR Proteomes; UP000003671; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015093; F:ferrous iron transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0046914; F:transition metal ion binding; IEA:InterPro.
DR CDD; cd01879; FeoB; 1.
DR FunFam; 3.40.50.300:FF:000426; Ferrous iron transport protein B; 1.
DR Gene3D; 1.10.287.1770; -; 1.
DR Gene3D; 2.30.30.90; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR007167; Fe-transptr_FeoA-like.
DR InterPro; IPR003373; Fe2_transport_prot-B.
DR InterPro; IPR011640; Fe2_transport_prot_B_C.
DR InterPro; IPR038157; FeoA_core_dom.
DR InterPro; IPR041069; FeoB_Cyto.
DR InterPro; IPR050860; FeoB_GTPase.
DR InterPro; IPR030389; G_FEOB_dom.
DR InterPro; IPR011642; Gate_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR008988; Transcriptional_repressor_C.
DR NCBIfam; TIGR00437; feoB; 1.
DR PANTHER; PTHR43185:SF1; FE(2+) TRANSPORTER FEOB; 1.
DR PANTHER; PTHR43185; FERROUS IRON TRANSPORT PROTEIN B; 1.
DR Pfam; PF04023; FeoA; 1.
DR Pfam; PF07664; FeoB_C; 1.
DR Pfam; PF17910; FeoB_Cyto; 1.
DR Pfam; PF02421; FeoB_N; 1.
DR Pfam; PF07670; Gate; 2.
DR SMART; SM00899; FeoA; 1.
DR SUPFAM; SSF50037; C-terminal domain of transcriptional repressors; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51711; G_FEOB; 1.
PE 3: Inferred from homology;
KW Cell inner membrane {ECO:0000256|ARBA:ARBA00022519};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134, ECO:0000256|PIRSR:PIRSR603373-
KW 1}; Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Iron {ECO:0000256|ARBA:ARBA00023004, ECO:0000256|RuleBase:RU362098};
KW Iron transport {ECO:0000256|ARBA:ARBA00022496,
KW ECO:0000256|RuleBase:RU362098};
KW Magnesium {ECO:0000256|PIRSR:PIRSR603373-2};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362098};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR603373-2};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|PIRSR:PIRSR603373-1};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362098};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362098};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU362098}.
FT TRANSMEM 405..427
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362098"
FT TRANSMEM 466..490
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362098"
FT TRANSMEM 510..533
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362098"
FT TRANSMEM 545..570
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362098"
FT TRANSMEM 576..595
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362098"
FT TRANSMEM 634..653
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362098"
FT TRANSMEM 668..687
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362098"
FT TRANSMEM 699..719
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362098"
FT TRANSMEM 725..744
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362098"
FT TRANSMEM 756..780
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362098"
FT DOMAIN 117..278
FT /note="FeoB-type G"
FT /evidence="ECO:0000259|PROSITE:PS51711"
FT BINDING 124..131
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /ligand_label="1"
FT /evidence="ECO:0000256|PIRSR:PIRSR603373-1"
FT BINDING 135
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /ligand_label="2"
FT /evidence="ECO:0000256|PIRSR:PIRSR603373-2"
FT BINDING 138
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /ligand_label="2"
FT /evidence="ECO:0000256|PIRSR:PIRSR603373-2"
FT BINDING 139
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /ligand_label="2"
FT /evidence="ECO:0000256|PIRSR:PIRSR603373-2"
FT BINDING 149..153
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /ligand_label="1"
FT /evidence="ECO:0000256|PIRSR:PIRSR603373-1"
FT BINDING 169..172
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /ligand_label="1"
FT /evidence="ECO:0000256|PIRSR:PIRSR603373-1"
FT BINDING 229..232
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /ligand_label="1"
FT /evidence="ECO:0000256|PIRSR:PIRSR603373-1"
SQ SEQUENCE 781 AA; 86290 MW; D24A9AF1943ADF23 CRC64;
MFLNELKAGE RAVVRSVGGE GALRQHFLDM GVIPGAEITL VKFAPMGDPI EFRIHEYELT
LRVDDAKQIG IEKLPKWESD QHPVVKIPHE PTDHPGLGEG GRYHVREGEH PLPDDQLLTF
ALAGNQNCGK TTLFNQLTGS NQHVGNFPGV TVDQKSGSIR GHENTKITDL PGIYSMSPYT
DEEIVSREFI LREQPTGIIN IVDATNIERN LYLTLQLIEL DRPMVLALNM MDELTGNGGS
VDINAMESLL GIPIVPISAS KGEGIEELVA HALHVAHYQE KPGRMDFCDA ESHRGAVHRC
LHGIMHLIED HAKEARIPVR FAATKIVEGD SRIIEALMLD QNEMEMIEHI ICQMEKERGL
DRSAAIADMR FSFIGKLVDR TFHKAHESRQ HERSRRIDKV LTGKYTAIPA FIAIMSLVFY
LTFNVIGAGL QDLLAAGIGL LQDQVDAAMT AAGVNEAMHS LVIDGIFQGV GTVLSFLPII
VTLFFFLSLL EDTGYMARIA FVMDKWLRKI GLSGRSIVPL LIGFGCSVPA IMSTRTLPSE
RDRRMTILLT PFMSCSAKLP IYGFFIAAFF GDYGALPMIV LYFGAMLVGI LVAYLGKNTI
FKGEAVPFVM ELPNYRMPGR RNVMQLLWEK SKDFLERAFS VIFIATIVIW FLQTFNFRLD
MVTDSSESML AAVAGIIAPI FAPLGFGDWR ISTALISGFM AKESVVSTLG VLFGTSSIST
VLTPLSAASL LAFCLLYTPC VAAITSVKRE LGTTWAIWVV IFQCVIAWIV SFIVHTIGLL
L
//
