ID C9LKM6_9BACT Unreviewed; 612 AA.
AC C9LKM6;
DT 24-NOV-2009, integrated into UniProtKB/TrEMBL.
DT 24-NOV-2009, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE RecName: Full=DNA mismatch repair protein MutL {ECO:0000256|HAMAP-Rule:MF_00149};
GN Name=mutL {ECO:0000256|HAMAP-Rule:MF_00149,
GN ECO:0000313|EMBL:EEX70342.1};
GN ORFNames=GCWU000325_02796 {ECO:0000313|EMBL:EEX70342.1};
OS Alloprevotella tannerae ATCC 51259.
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Prevotellaceae;
OC Alloprevotella.
OX NCBI_TaxID=626522 {ECO:0000313|EMBL:EEX70342.1, ECO:0000313|Proteomes:UP000003460};
RN [1] {ECO:0000313|EMBL:EEX70342.1, ECO:0000313|Proteomes:UP000003460}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51259 {ECO:0000313|EMBL:EEX70342.1,
RC ECO:0000313|Proteomes:UP000003460};
RA Weinstock G., Sodergren E., Clifton S., Fulton L., Fulton B., Courtney L.,
RA Fronick C., Harrison M., Strong C., Farmer C., Delahaunty K., Markovic C.,
RA Hall O., Minx P., Tomlinson C., Mitreva M., Nelson J., Hou S., Wollam A.,
RA Pepin K.H., Johnson M., Bhonagiri V., Nash W.E., Warren W., Chinwalla A.,
RA Mardis E.R., Wilson R.K.;
RL Submitted (SEP-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is required for dam-dependent methyl-directed DNA mismatch repair.
CC May act as a 'molecular matchmaker', a protein that promotes the
CC formation of a stable complex between two or more DNA-binding proteins
CC in an ATP-dependent manner without itself being part of a final
CC effector complex. {ECO:0000256|HAMAP-Rule:MF_00149}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000256|ARBA:ARBA00006082, ECO:0000256|HAMAP-Rule:MF_00149}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EEX70342.1}.
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DR EMBL; ACIJ02000030; EEX70342.1; -; Genomic_DNA.
DR RefSeq; WP_006256626.1; NZ_GG700644.1.
DR AlphaFoldDB; C9LKM6; -.
DR STRING; 626522.GCWU000325_02796; -.
DR GeneID; 84577301; -.
DR eggNOG; COG0323; Bacteria.
DR HOGENOM; CLU_004131_4_0_10; -.
DR OrthoDB; 9763467at2; -.
DR Proteomes; UP000003460; Unassembled WGS sequence.
DR GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd16926; HATPase_MutL-MLH-PMS-like; 1.
DR CDD; cd00782; MutL_Trans; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.1540.20; MutL, C-terminal domain, dimerisation subdomain; 1.
DR Gene3D; 3.30.1370.100; MutL, C-terminal domain, regulatory subdomain; 1.
DR HAMAP; MF_00149; DNA_mis_repair; 1.
DR InterPro; IPR014762; DNA_mismatch_repair_CS.
DR InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR002099; MutL/Mlh/PMS.
DR InterPro; IPR038973; MutL/Mlh/Pms-like.
DR InterPro; IPR014790; MutL_C.
DR InterPro; IPR042120; MutL_C_dimsub.
DR InterPro; IPR042121; MutL_C_regsub.
DR InterPro; IPR037198; MutL_C_sf.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR NCBIfam; TIGR00585; mutl; 1.
DR PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR PANTHER; PTHR10073:SF12; DNA MISMATCH REPAIR PROTEIN MLH1; 1.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF13589; HATPase_c_3; 1.
DR Pfam; PF08676; MutL_C; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SMART; SM00853; MutL_C; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF118116; DNA mismatch repair protein MutL; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00149};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00149}; Reference proteome {ECO:0000313|Proteomes:UP000003460}.
FT DOMAIN 209..326
FT /note="DNA mismatch repair protein S5"
FT /evidence="ECO:0000259|SMART:SM01340"
FT DOMAIN 430..571
FT /note="MutL C-terminal dimerisation"
FT /evidence="ECO:0000259|SMART:SM00853"
SQ SEQUENCE 612 AA; 68408 MW; 645A3649C60E6115 CRC64;
MSDIIHLLPD SVANQIAAGE VIQRPSSIVK ELIENSIDAE SSLIQVFITD AGKSCVQIVD
NGKGMSEMDA RLSFERHATS KISTPSDLFA LKTMGFRGEA LASIAAVAQV ELKTRTEEEE
LGICVDVEGG RIKSQSVVAC PVGANFSVRN IFFNIPARRK FLKSNQTEMG SIMSEFERLA
LANPSVAFKL YNNNSLLIDL PAGNFRQRIK ALFGSKLDEQ LMSIEVKTEL VSIKGFVGSP
NSSKKKCHQF FFVNGRYMRH NYFAKAIQTA FERLIPENEQ IPYFVALEVD PSRIDVNIHP
TKTEIKFQDE GAIWQVVLAC VREALGKYAA VPLIEFDTNN KPVMPVFEPI DKAQVLSPPQ
VHINQNFNPF NKERSHQNTR QVESNWERDL DRLFQSRRSE LSALTEEQST LLAKSPSLEG
FDVDDLSDKY MQLLGRFILL PVKSGLMLVE QHRADVRILY DYYLRQIKNQ AGPSQGILFP
QTIHFSPTEK VYLEKILLPL TDIGFDLTQQ TNGEYEVRGI PSGTEGLDIS DLLLNIVQEL
KQGNIEAINE IHHHVALTLA SKSAIPIGEA LSNEEMGNLM QRLFACECPN YGPDGATILA
IIQSEKILSI FS
//
