ID C9P1K5_VIBME Unreviewed; 888 AA.
AC C9P1K5;
DT 24-NOV-2009, integrated into UniProtKB/TrEMBL.
DT 24-NOV-2009, sequence version 1.
DT 27-MAR-2024, entry version 77.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN ORFNames=VIB_000353 {ECO:0000313|EMBL:EEX38407.1};
OS Vibrio metschnikovii CIP 69.14.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC Vibrio.
OX NCBI_TaxID=675813 {ECO:0000313|EMBL:EEX38407.1, ECO:0000313|Proteomes:UP000005604};
RN [1] {ECO:0000313|EMBL:EEX38407.1, ECO:0000313|Proteomes:UP000005604}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CIP 69.14 {ECO:0000313|EMBL:EEX38407.1,
RC ECO:0000313|Proteomes:UP000005604};
RG Los Alamos National Laboratory (LANL);
RG National Microbial Pathogen Data Resource (NMPDR);
RA Munk A.C., Tapia R., Green L., Rogers Y., Detter J.C., Bruce D.,
RA Brettin T.S., Colwell R.R., Huq A., Grim C.J., Hasan N.A., Bartels D.,
RA Vonstein V.;
RL Submitted (OCT-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
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DR EMBL; ACZO01000004; EEX38407.1; -; Genomic_DNA.
DR RefSeq; WP_004394312.1; NZ_ACZO01000004.1.
DR AlphaFoldDB; C9P1K5; -.
DR STRING; 675813.VIB_000353; -.
DR GeneID; 79888655; -.
DR eggNOG; COG2205; Bacteria.
DR Proteomes; UP000005604; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR GO; GO:0034220; P:monoatomic ion transmembrane transport; IEA:UniProtKB-KW.
DR CDD; cd00082; HisKA; 1.
DR Gene3D; 1.10.287.130; -; 1.
DR Gene3D; 3.30.450.40; -; 1.
DR Gene3D; 1.20.120.620; Backbone structure of the membrane domain of e. Coli histidine kinase receptor kdpd; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR029016; GAF-like_dom_sf.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR003661; HisK_dim/P.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR InterPro; IPR038318; KdpD_sf.
DR InterPro; IPR025201; KdpD_TM.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR InterPro; IPR003852; Sig_transdc_His_kinase_KdpD_N.
DR PANTHER; PTHR45569; SENSOR PROTEIN KDPD; 1.
DR PANTHER; PTHR45569:SF1; SENSOR PROTEIN KDPD; 1.
DR Pfam; PF13493; DUF4118; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF00512; HisKA; 1.
DR Pfam; PF02702; KdpD; 1.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00388; HisKA; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF55781; GAF domain-like; 1.
DR SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50109; HIS_KIN; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Ion channel {ECO:0000313|EMBL:EEX38407.1};
KW Ion transport {ECO:0000313|EMBL:EEX38407.1};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:EEX38407.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000005604};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000313|EMBL:EEX38407.1};
KW Two-component regulatory system {ECO:0000256|ARBA:ARBA00023012}.
FT TRANSMEM 397..413
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 419..438
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 445..466
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 472..490
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 665..882
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
SQ SEQUENCE 888 AA; 99992 MW; C88011FA4D062AE4 CRC64;
MHEEHRSQKA EALLCQIQKE SQGKLTIFLG AAPGVGKTYA MLNAGKECLQ RGVDVVIGLV
ETHGRQETES TMKGLEILPR KNIHYQHTLL TEFDLDAALQ RKPSLILVDE LAHTNVPGSR
HIRRWQDISE LLSTGIDVYT TVNIQHISSL NDVIAQVTGV TVREIVPDNF IDDAYEIRFI
DLPPVALIER LHQGKVYLPE YAKLALDTFF SIANLTALRE LAMKRVISKV DSHWNTMVDA
EQGKISYTLQ DNLVVLVSAN SDHRYLIRIG RKIAERRQIL WSVVWVDKGS PLTSQQRKML
NDALNLGKDL GAKVEIMRGS SCYDTVYSYL IDQRASTVLV GVGERYRYLF WRKRLYQRLI
ESGLPLEVSV YHSPESKVKI VKSNPIDPIY NRIKKHIYAL INVGLASLLA LALKEVLSSG
NLVLVFVLSI ILTGLKLGAR PAIAAAIYSF LSFNFLLTEP LLTFKVYSQD DIATLVFLII
IGLVSGPTAS RIRNQFILLK ESNRYAEILR ELAQQLSIVE SEKTLWSTVC KNISSLVQAP
SWFVTQQNDE IIFPSTFINI KLKACDESAI SWSLANAKPA GRFTDTLNAS QVTVIPIVHH
ELTIGVVVIG WKKNHRDFTQ FDKDLINSML NQASNTWQRI RLSTDLEASR VKTEVEQIRS
SLLSSVSHDL KSPLSAMMGA AETLKEFDDK LIKSQKIEML DTILQESRRL ESYIQNLLDM
TKLGYGGLKI ERDWVSIDDI VSSVISRLRR YFPNTKVNYF SQEDAPLLYV HAALIEQAIF
NILENSSRYT PEKESIAVHL NIDNNSCIIA IEDRGPGIPD DKKDSIFNMF YVISDGDNKK
NNTGMGLAIC KGMISAHGGK VRVKDRAHGR GTRFEIELPL AYPTVEIK
//
