ID C9P788_VIBME Unreviewed; 687 AA.
AC C9P788;
DT 24-NOV-2009, integrated into UniProtKB/TrEMBL.
DT 24-NOV-2009, sequence version 1.
DT 27-MAR-2024, entry version 66.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN ORFNames=VIB_002379 {ECO:0000313|EMBL:EEX36065.1};
OS Vibrio metschnikovii CIP 69.14.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC Vibrio.
OX NCBI_TaxID=675813 {ECO:0000313|EMBL:EEX36065.1, ECO:0000313|Proteomes:UP000005604};
RN [1] {ECO:0000313|EMBL:EEX36065.1, ECO:0000313|Proteomes:UP000005604}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CIP 69.14 {ECO:0000313|EMBL:EEX36065.1,
RC ECO:0000313|Proteomes:UP000005604};
RG Los Alamos National Laboratory (LANL);
RG National Microbial Pathogen Data Resource (NMPDR);
RA Munk A.C., Tapia R., Green L., Rogers Y., Detter J.C., Bruce D.,
RA Brettin T.S., Colwell R.R., Huq A., Grim C.J., Hasan N.A., Bartels D.,
RA Vonstein V.;
RL Submitted (OCT-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC {ECO:0000256|ARBA:ARBA00009922}.
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DR EMBL; ACZO01000007; EEX36065.1; -; Genomic_DNA.
DR RefSeq; WP_004396668.1; NZ_ACZO01000007.1.
DR AlphaFoldDB; C9P788; -.
DR STRING; 675813.VIB_002379; -.
DR GeneID; 79889276; -.
DR eggNOG; COG0210; Bacteria.
DR Proteomes; UP000005604; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR CDD; cd18807; SF1_C_UvrD; 1.
DR Gene3D; 1.10.10.160; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR022161; Helicase_IV_N.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF63; DNA HELICASE IV; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF12462; Helicase_IV_N; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000005604}.
FT DOMAIN 198..511
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT BINDING 219..226
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 687 AA; 79377 MW; 4E4CF941BD7B6C30 CRC64;
MQLSATQTAQ FFIANEYHHV GLENQRLVLS SLHSEERIPF TVWNGQVKVR RGILWAELRF
FAHPEQDTQR VWVVQGLPWP QARQFAHHIV NVYQQWLEQQ CQQLRLHLPQ WQQKLHHLQH
LPAFLPHSPL EEWINHVFAD LTAMNMSLEE AIKHLPHVME PLVPWLLTPD QALQARNQAW
LDIERQNWTV LFSQLESSPL NVSQQQAVLI NDDHNLVLAG AGSGKTSVLT ARVAYLLQSH
LAQADELLLV AFGKDAANEM DQRLKSKIGL AADKIRVNTF HQLGLSIINQ VENQSVVISP
LALDDKLKKA WCTDWLKRHW MTPTNFKRWQ KHLAQWPIAY LVGDDELGSH VENPKLIAWL
EKQLDQLAQL GTTKKAIQQY IIDHVDYPRL NSELALCWPC YQAWQQMLKD EQQIDFNIMI
SQATDYVRKG KFSVPWKFIM IDEYQDISPA RLALIQALCE QGPNHPNLFA VGDDWQSIYQ
FAGSDVHLTT EFAARFPQST IHHLDTTYRF NDQIGLVANQ FVQKNPHQLP KTLNSFKSQK
QRAVVLCASN QIEKILDKLN RQAKVPKQVL LLGRNHYHQP EHLAEWQRRY ASLQIEFMTC
HASKGKEADF VIILAVNEGQ FPARVKARHL DSALTQSKVD FPFAEERRLF YVAMTRAKEK
VWITYSGNGS CFIQELLTEG YPVSKSI
//
