ID C9QPK7_CAEBR Unreviewed; 264 AA.
AC C9QPK7;
DT 24-NOV-2009, integrated into UniProtKB/TrEMBL.
DT 24-NOV-2009, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE RecName: Full=Cyanocobalamin reductase (cyanide-eliminating) {ECO:0000256|ARBA:ARBA00031313};
GN Name=cblc-1 {ECO:0000313|WormBase:CBG28142};
GN ORFNames=CBG28142 {ECO:0000313|EMBL:CBG92367.1,
GN ECO:0000313|WormBase:CBG28142}, CBG_28142
GN {ECO:0000313|EMBL:CBG92367.1};
OS Caenorhabditis briggsae.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6238 {ECO:0000313|EMBL:CBG92367.1, ECO:0000313|Proteomes:UP000008549};
RN [1] {ECO:0000313|EMBL:CBG92367.1, ECO:0000313|Proteomes:UP000008549}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AF16 {ECO:0000313|EMBL:CBG92367.1,
RC ECO:0000313|Proteomes:UP000008549};
RX PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA Fitch D.H., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA Durbin R., Waterston R.H.;
RT "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT genomics.";
RL PLoS Biol. 1:166-192(2003).
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
CC -!- COFACTOR:
CC Name=FMN; Xref=ChEBI:CHEBI:58210;
CC Evidence={ECO:0000256|ARBA:ARBA00001917};
CC -!- SIMILARITY: Belongs to the MMACHC family.
CC {ECO:0000256|ARBA:ARBA00007762}.
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DR EMBL; HE601438; CBG92367.1; -; Genomic_DNA.
DR AlphaFoldDB; C9QPK7; -.
DR STRING; 6238.C9QPK7; -.
DR EnsemblMetazoa; CBG28142.1; CBG28142.1; WBGene00194763.
DR WormBase; CBG28142; CBP37600; WBGene00194763; Cbr-cblc-1.
DR eggNOG; KOG4552; Eukaryota.
DR HOGENOM; CLU_095722_0_0_1; -.
DR InParanoid; C9QPK7; -.
DR OMA; SDPVDQC; -.
DR OrthoDB; 3035512at2759; -.
DR Proteomes; UP000008549; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0031419; F:cobalamin binding; IEA:EnsemblMetazoa.
DR GO; GO:0033787; F:cyanocobalamin reductase (cyanide-eliminating) activity; IBA:GO_Central.
DR GO; GO:0032451; F:demethylase activity; IBA:GO_Central.
DR GO; GO:0071949; F:FAD binding; IBA:GO_Central.
DR GO; GO:0009235; P:cobalamin metabolic process; IBA:GO_Central.
DR CDD; cd12959; MMACHC-like; 1.
DR InterPro; IPR032037; MMACHC.
DR PANTHER; PTHR31457:SF2; CYANOCOBALAMIN REDUCTASE _ ALKYLCOBALAMIN DEALKYLASE; 1.
DR PANTHER; PTHR31457; METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE C PROTEIN; 1.
DR Pfam; PF16690; MMACHC; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000008549}.
FT COILED 88..115
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 264 AA; 30423 MW; A79CE9E938D5B1D1 CRC64;
MERAESIKKA VDQHLPSKDG FETHMFRIGS YNRSVGDPFS LPYDDSTMAL LILSTPDMFD
VAFRKWVVQK TMEFGSFDMS EFVSSPIQSF LEDRLEDLSE KLQSVEENFE ILHDYMTPQR
RPKILMQTCG HVAGAAFYYQ PCHFQEDGLA WPSSGRMGPN LKFIGLSLHP IYGGHFAFRS
VLIFPNVLIP DFKESVPLPI LKEASEVRTA LEKFNYNWKD SGFRDFGNPA RRYSTTQMEF
FGRPVAERWE VLRPWIEGGA KHID
//
