ID C9RMT1_FIBSS Unreviewed; 894 AA.
AC C9RMT1;
DT 24-NOV-2009, integrated into UniProtKB/TrEMBL.
DT 24-NOV-2009, sequence version 1.
DT 27-MAR-2024, entry version 75.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN OrderedLocusNames=FSU_1135 {ECO:0000313|EMBL:ADL24987.1};
OS Fibrobacter succinogenes (strain ATCC 19169 / S85).
OC Bacteria; Fibrobacterota; Fibrobacteria; Fibrobacterales; Fibrobacteraceae;
OC Fibrobacter.
OX NCBI_TaxID=59374 {ECO:0000313|EMBL:ADL24987.1, ECO:0000313|Proteomes:UP000000517};
RN [1] {ECO:0000313|Proteomes:UP000000517}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 19169 / S85 {ECO:0000313|Proteomes:UP000000517};
RA Durkin A.S., Nelson K.E., Morrison M., Forsberg C.W., Wilson D.B.,
RA Russell J.B., Cann I.K.O., Mackie R.I., White B.A.;
RT "Complete sequence of Fibrobacter succinogenes subsp. succinogenes S85.";
RL Submitted (AUG-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
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DR EMBL; CP002158; ADL24987.1; -; Genomic_DNA.
DR RefSeq; WP_014545471.1; NC_017448.1.
DR AlphaFoldDB; C9RMT1; -.
DR STRING; 59374.FSU_1135; -.
DR REBASE; 22227; Fsu85ORF699P.
DR REBASE; 27332; FssORF1135P.
DR GeneID; 34755056; -.
DR KEGG; fsc:FSU_1135; -.
DR PATRIC; fig|59374.8.peg.1096; -.
DR eggNOG; COG0286; Bacteria.
DR HOGENOM; CLU_015410_1_0_0; -.
DR OrthoDB; 9814572at2; -.
DR Proteomes; UP000000517; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0006306; P:DNA methylation; IEA:InterPro.
DR GO; GO:0009307; P:DNA restriction-modification system; IEA:UniProtKB-KW.
DR Gene3D; 3.90.220.20; DNA methylase specificity domains; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR003356; DNA_methylase_A-5.
DR InterPro; IPR044946; Restrct_endonuc_typeI_TRD_sf.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR42933:SF1; SITE-SPECIFIC DNA-METHYLTRANSFERASE (ADENINE-SPECIFIC); 1.
DR PANTHER; PTHR42933; SLR6095 PROTEIN; 1.
DR Pfam; PF02384; N6_Mtase; 2.
DR SUPFAM; SSF116734; DNA methylase specificity domain; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Endonuclease {ECO:0000313|EMBL:ADL24987.1};
KW Hydrolase {ECO:0000313|EMBL:ADL24987.1};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:ADL24987.1}; Nuclease {ECO:0000313|EMBL:ADL24987.1};
KW Restriction system {ECO:0000256|ARBA:ARBA00022747};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:ADL24987.1}.
FT DOMAIN 353..481
FT /note="DNA methylase adenine-specific"
FT /evidence="ECO:0000259|Pfam:PF02384"
FT DOMAIN 487..582
FT /note="DNA methylase adenine-specific"
FT /evidence="ECO:0000259|Pfam:PF02384"
FT COILED 172..206
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 894 AA; 101419 MW; 0A80BF8119D47AC7 CRC64;
MAKSIEEQVE DWCKNQLENY FTKTESINSE IDKALKTAPS KKGGSGQNLP DIKCFVSVGF
RNIPVMIECK GTKGDFAKTD ENGLISNTNK KGETDYTAIT KYAVNGAIHY AKSILDFTET
YKETIAIGVN GYKQDNDLQL EIGVYYLSKD NLAIPKKVGD FSDLSFLKKK NLKEFFEKID
ELKLTLEEIE SRKLALEDEI ETKLKRLNQT MHDDLSITVK SRVMLIVGLI MAGLGVEDVS
EGLKVEELKG ELGPKSNDAQ KIINKVEDFL RMKNLPEEKR EAIMHELSNV FKNEDLYKPK
NGESKLRKVY VIVHKDILPY LTSDLPNIDF TGRLFNVLND WVDVPDGAEN DVVLTPRYVT
ELMAKLTEVN MNSYVWDYAT GSAGFLISAM HLMIADAKNK IKSPEELRKT IAKIKAEKLL
GIEKLPEIYI LAVLNMILMG DGSSNIINGD STQFDGKYKQ GKMKDKEFPA NVFLLNPPYS
APGKGLNFVE KALSKMKSGK AAVLIQENAG STQGDGYTKK ILNKNTLIAS IHMSTDLFIG
KSSVQTAIYV FDVGIPHDTE KLVKFIDFSN DGYARQNRKK SSQSVNLKDA DNAKERYAEL
VNLVVRGKGK DDKNLNYYKD CYVEDYITSE GNDWTYSQHK KIDIKPTEND FKKIIKEYMA
WQISNLIRNE DIYPWTNKSP EQSNCILSKK ERDCIQMKNA TFKAITIGSL FDIHPTKAYK
ATNKDLFKEK GKVPVVANSS VDNGIGGWTN LKATEKGNKV VFSDTTTSDS IFYQPNDFVG
YPHVQGLYPY CNKWDENSLL YFITCFRKSA SGLFNYGNKF TRKNALKMKV FLPEKNKEDI
DFSFMETFIS AQKKLIIQKL SCWLEQQKIN NEIYIIEKEI PQDTLSMIAE KKHH
//
