ID C9RQA8_FIBSS Unreviewed; 1266 AA.
AC C9RQA8;
DT 24-NOV-2009, integrated into UniProtKB/TrEMBL.
DT 24-NOV-2009, sequence version 1.
DT 27-MAR-2024, entry version 98.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN Name=recB {ECO:0000313|EMBL:ADL25288.1};
GN OrderedLocusNames=FSU_1644 {ECO:0000313|EMBL:ADL25288.1};
OS Fibrobacter succinogenes (strain ATCC 19169 / S85).
OC Bacteria; Fibrobacterota; Fibrobacteria; Fibrobacterales; Fibrobacteraceae;
OC Fibrobacter.
OX NCBI_TaxID=59374 {ECO:0000313|EMBL:ADL25288.1, ECO:0000313|Proteomes:UP000000517};
RN [1] {ECO:0000313|Proteomes:UP000000517}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 19169 / S85 {ECO:0000313|Proteomes:UP000000517};
RA Durkin A.S., Nelson K.E., Morrison M., Forsberg C.W., Wilson D.B.,
RA Russell J.B., Cann I.K.O., Mackie R.I., White B.A.;
RT "Complete sequence of Fibrobacter succinogenes subsp. succinogenes S85.";
RL Submitted (AUG-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
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DR EMBL; CP002158; ADL25288.1; -; Genomic_DNA.
DR RefSeq; WP_014545905.1; NC_017448.1.
DR AlphaFoldDB; C9RQA8; -.
DR STRING; 59374.FSU_1644; -.
DR GeneID; 34755531; -.
DR KEGG; fsc:FSU_1644; -.
DR PATRIC; fig|59374.8.peg.1585; -.
DR eggNOG; COG1074; Bacteria.
DR HOGENOM; CLU_001114_6_1_0; -.
DR OrthoDB; 9810135at2; -.
DR Proteomes; UP000000517; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0008854; F:exodeoxyribonuclease V activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR CDD; cd22352; RecB_C-like; 1.
DR Gene3D; 3.90.320.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 1.10.3170.10; Recbcd, chain B, domain 2; 1.
DR HAMAP; MF_01485; RecB; 1.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011604; PDDEXK-like_dom_sf.
DR InterPro; IPR004586; RecB.
DR InterPro; IPR011335; Restrct_endonuc-II-like.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF23; RECBCD ENZYME SUBUNIT RECB; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52980; Restriction endonuclease-like; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}.
FT DOMAIN 1..451
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 473..756
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT REGION 934..964
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 944..964
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 19..26
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 1266 AA; 145434 MW; E093199C1D90B78A CRC64;
MENFSLNKFD PSQSLFIEAS AGTGKTYTIQ LMVSKLIKLG TPLKKILIVT YTEKAAGELK
DRIRKKIDEV LINRKIDKSD DSEEPLSDAK IALFTKAYQD VDNAAIFTIH SFCQKALKEF
AYDAGRPFNM SMIDDKEVND LIEKFIRDNW SEDEEFKALL VNAEKTSSLI NKLKDLFTKA
INVYKGKNDN GEEIIKLESP SIEWGEDCIS KEEAEALLEK DIVDFESLKK FKKFYSNVQI
LEKDENKDKI YYSEEISSGE KAISDLLNTI HTWDSSTKNP FTPTKIGKNI TDVPNDEFGN
ALKYVHERIS KLSKIKEALQ EELDSYPLKK FLFDHIPELF DEWQKYKTDM KAQSFNDMIL
SVHQAVLDKS KGESPLKTRL RAQYTYAIID EFQDTNQLQW DIFSAVFDKI FVVGDPKQSI
YSFQGADVNV YQKAIQKINN GMSLKTNFRS TKGIIDGCND LFNDSFFKPY EGSPKLVDFE
SSLSPDKEGQ VKALPQINGK EVAPIWISQQ NIDEIDFAQA TVQKIVEWCS FVGDKTVLQV
FDKKDCTKLR NVSFKDFAVL ARTRSEMDEI EDAMRAAGVP FSRYKDSNLF SSRECTEWIA
LFKAIDAPDF SAWNRRLLSE ALITDFFRIS YQEIEYVESE AFDDPENPVR KKINSWHELV
QKRRYAEMLE RIYSDTQIEE RLTEISKLQN LAKLRQIGNY AVEYLYNHNC SIEDLVRHLE
ALASYNAGTD DEDGNLIEKS TDYDAVQIMT IHASKGLEFP IVISVAGFKQ KIKTDSGPFL
YHDKDEIRLG FGSIAKKRRA QEELEEWKRL FYVDFTRASS ILILPRYEKW YGKDNVKEEF
KFLESSINEL IKADEKRDSD KKLTTVLPKL EKWEPKKLSD DVKTKILKPL NEKSGAGAVL
TSEEIAQNIA QQKINMASLQ KKLAGASIMQ HSYSTLSGKA DSQIESDDGN RPDRDDEEKT
AAKTSTVKIR DIDTEAKNCT TAFNPKLNYQ TNLNETAKKF PRGSHAGNAL HRIFENTKFK
QFGEENSTFE QALANPKTIN LIEEEFKRES LPIWNHREAW LDIATHYTWN TLNARLPEIA
GSTTTSETFA LTDIPENDHM PEVQFNQDAS EETDENQAIS ETSASDILRR FCKGFIDLLF
VRTVNSQKYY SILDWKSDML ENNVYTPEAL KEKVDNDYSI QRVLYSYCLI QWLKQFYGKG
TTENLSEAEI FEKHFGGIYY AFIRGTEGGT PKGIYAQTWN SFGELEKAYQ KVKDLMSKPS
IVKEEK
//
