ID C9SFR8_VERA1 Unreviewed; 3746 AA.
AC C9SFR8;
DT 24-NOV-2009, integrated into UniProtKB/TrEMBL.
DT 24-NOV-2009, sequence version 1.
DT 27-MAR-2024, entry version 76.
DE SubName: Full=Transcription-associated protein {ECO:0000313|EMBL:EEY18013.1};
GN ORFNames=VDBG_04122 {ECO:0000313|EMBL:EEY18013.1};
OS Verticillium alfalfae (strain VaMs.102 / ATCC MYA-4576 / FGSC 10136)
OS (Verticillium wilt of alfalfa) (Verticillium albo-atrum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Glomerellales; Plectosphaerellaceae; Verticillium.
OX NCBI_TaxID=526221 {ECO:0000313|Proteomes:UP000008698};
RN [1] {ECO:0000313|Proteomes:UP000008698}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VaMs.102 / ATCC MYA-4576 / FGSC 10136
RC {ECO:0000313|Proteomes:UP000008698};
RX PubMed=21829347; DOI=10.1371/journal.ppat.1002137;
RA Klosterman S.J., Subbarao K.V., Kang S., Veronese P., Gold S.E.,
RA Thomma B.P.H.J., Chen Z., Henrissat B., Lee Y.-H., Park J.,
RA Garcia-Pedrajas M.D., Barbara D.J., Anchieta A., de Jonge R., Santhanam P.,
RA Maruthachalam K., Atallah Z., Amyotte S.G., Paz Z., Inderbitzin P.,
RA Hayes R.J., Heiman D.I., Young S., Zeng Q., Engels R., Galagan J.,
RA Cuomo C.A., Dobinson K.F., Ma L.-J.;
RT "Comparative genomics yields insights into niche adaptation of plant
RT vascular wilt pathogens.";
RL PLoS Pathog. 7:E1002137-E1002137(2011).
CC -!- FUNCTION: Serine/threonine protein kinase which activates checkpoint
CC signaling upon genotoxic stresses such as ionizing radiation (IR),
CC ultraviolet light (UV), or DNA replication stalling, thereby acting as
CC a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-
CC Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of
CC DNA damage, involved in the regulation of DNA damage response
CC mechanism. Required for the control of telomere length and genome
CC stability. {ECO:0000256|ARBA:ARBA00025079}.
CC -!- SUBUNIT: Associates with DNA double-strand breaks.
CC {ECO:0000256|ARBA:ARBA00011370}.
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DR EMBL; DS985217; EEY18013.1; -; Genomic_DNA.
DR RefSeq; XP_003006169.1; XM_003006123.1.
DR STRING; 526221.C9SFR8; -.
DR GeneID; 9534650; -.
DR KEGG; val:VDBG_04122; -.
DR eggNOG; KOG0889; Eukaryota.
DR HOGENOM; CLU_000129_1_0_1; -.
DR OMA; CLDLYGQ; -.
DR OrthoDB; 3666795at2759; -.
DR Proteomes; UP000008698; Unassembled WGS sequence.
DR GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR CDD; cd05163; PIKK_TRRAP; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR003152; FATC_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR003151; PIK-rel_kinase_FAT.
DR InterPro; IPR014009; PIK_FAT.
DR InterPro; IPR046807; Tra1_central.
DR InterPro; IPR046805; Tra1_ring.
DR PANTHER; PTHR11139; ATAXIA TELANGIECTASIA MUTATED ATM -RELATED; 1.
DR PANTHER; PTHR11139:SF1; TRANSFORMATION_TRANSCRIPTION DOMAIN-ASSOCIATED PROTEIN; 1.
DR Pfam; PF02259; FAT; 1.
DR Pfam; PF02260; FATC; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF20175; Tra1_central; 1.
DR Pfam; PF20206; Tra1_ring; 1.
DR SMART; SM01343; FATC; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF48371; ARM repeat; 2.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51189; FAT; 1.
DR PROSITE; PS51190; FATC; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 4: Predicted;
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW Reference proteome {ECO:0000313|Proteomes:UP000008698}.
FT DOMAIN 2538..3095
FT /note="FAT"
FT /evidence="ECO:0000259|PROSITE:PS51189"
FT DOMAIN 3373..3717
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT DOMAIN 3714..3746
FT /note="FATC"
FT /evidence="ECO:0000259|PROSITE:PS51190"
FT REGION 1889..1925
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3103..3201
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3156..3176
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3180..3199
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3746 AA; 426983 MW; 7F6B67F743D3D051 CRC64;
MSGTTIDDVV KRLSTPETER LMDANTETKI KVEAATTLRD SLDHYTAGPI YAPFLKKLMP
IFINILKGPC IFQSNSPEQK LRNCILEVLH RLPTHPSPTE PFEPFAEEIV DLLMHLVRTD
NEENATLCVK IISDIMRHQH KVLAQKVQPF LTLIQELFEQ MEKVVREQLT NYQQNRLLLK
GMSSFKVLSE CPIIVVSIFQ VYRNTVGSNV KLFVPLIKGV LCLQASAQRQ AHADAKAKGQ
IFTGVSPLIK NRAAFGEFIT AQVKTMSFLA YLLRQYSQQL QDFLPTLPEI VVRLLKDCPR
EKSSTRKELL VAIRHIINFN FRKIFLSKID ELLDEKTLIG DGLTVYETMR PLAYSMLADL
IHHVRDQLSP EQIRKTVEVY TKNLQDNFPG TSFQTMSAKL LLNMAECIAK MQDKVDARHY
LMMILSAIGD KFKAMNTQYP NAVKLSKLYK QQAAEGTADS YLADKEHPPD WDETDIFTAM
PIKPTNPRDR GLDPVADNKF LFKNLMNGLK NTFYQLRTCN AGTNVNLQNA PAQWQEVAYG
FTAEEVKVIV KLFREGAYVF RYYEIEKPAS ESQYMSPVEY MANFYMVSSS KEEKDLLETF
ATVFHCIDPA TFHEVFQQEI PHLYDMIFEH TALLHIPQFF LASEATSPSF CGMLLRFLMD
RIDQVGSADV KRSSILLRLF KLAFMAVTLF ANQNEQVLLP HVVDIVTKSI DLSTRAEEPM
NYFLLLRSLF RSIGGGKFEH LYKQILPLLE MLLDVLNTLL MAARKQTERD LYVELCLTVP
ARLSNLLPHL SFLMRPLVVA LRAGTDLVGQ GLRTLELCVD NLTADYLDPI MAPVIDELMT
ALFDHLRPHP YSHFHAHTTM RILGKLGGRN RKYITGPQPL SFEDFADDAT SFDLRLVGSK
KDRAFPAELG VDLSIRKLME VPKPSKANQS RHFDGYYKKQ SFHFIKSQLK LRIGFDNLPD
DLPRLLRLQA QDLLSRKIEV DLSAFDASDR DRSIAKKDQQ DELVRRLLKA VMFAESLPEF
KDEAASFLIN VARHFTIVDI GRSVVDVKHT YSQFNPTAGE GPLYIDTRVF SDAIVESLSS
EHPDVRDSAR RVIREIYITA STIFGSAQSA ARLPFFGNLS TTFCHACYEE EWFTKAGGTL
GVNFLLTELE LGDQWAISKQ TDFIRALMYV VKDMPQDLPE KTRSSAQLTL EILLKKVTKN
AKKEDALPST TPGQAPQRHR LAQICMHFNN ELAHMNRHVR ETAKRSLELI AKAASCEVWE
LIEPYKERFL QPIYSKPLRA LPFPATIDAA NDALKSVLQQ TNKLPKDLLQ GGLRPVLASL
QDPKKLTSHG LDNLARLLKL LTTYFKVEIG SRLLDHVKIL ADPNVLQAIS FTYFEQHSQM
KVVSAVFNIF HLLPPAAETF KERLIDLVLD LEEKLRRTHV SPFRPPLYKY LNRYPAEMWA
FLMPKIGEVK YGRFLAQVLS HPDSGPLRKE AVSGVDNLVK ACNEIVTQDK ETKFVAIINT
IHVLDSLGQW PACDAWMDKK EILTWMKQVG KELEAQLRKY TLAANLRMPA AQASEQLMNI
LLKSLERNPK DLESLFSIVE AVTSEDFRDP QPLIAYVYKN IINNDSVEIG VAAILKCLEA
YSSRNVSQKM KCFLLHNIVN PTIAMDVQRH WNSTQQGQPR LIDRAVIDAV VAKVWKSNQD
TSQQDHDDLA QPGIDHTKFE VLQLSALLLK YHYQTIQETR KDIIKSCWTF IRLDDVINKH
AAYVVIGYFI ALYDTPIKIV TQVYLSLLKA NQNEGRALVT QALELVAPVL PKRLNTPQND
RNAAWAIAPR RVLADEGQNA QQMTSIFHFL VRHPELFYDS RDKYAMLIIT SLRKVAAPAT
ASNESKKLAL NMMWLIWLWE QRRVEGKGDA LVRSQSQSPN SKKRKLDGDQ PMSSPPSVKQ
QLAPNDYQIP PVGRLKMIRY LIEFIAQLNE RYQVPSAKFK DSPTLAGFAS PSASSTELCK
KSMSLLYHLL QPQYWSDLDI DLFPHVTDAV LASDRTQTVL TADPSDKEKF DNKFITNIIN
TLQVVRIILN VKSDDWVQKN MSSIQKVLDK CLRSENPEIQ DCLHAADPEN DDNRELKAIV
KRVLEAVPED VPMEDADADG ETEAQTSEII QALSTTAGEA MAAGNYTSGV NTLWSLGNRK
PTIIDQHIPV LMKALQSKLA REHVQHYSIV ANLQAGGAPP NRGPDAPPSG EMSTYDLEVS
TALMLKAMQV VALRMEVLGD NRRPFLSVLA TLVEKSMHIP LCEEILVMVE GWVFRSEGTW
PTLKEKTAVL HKMLSFEHRQ DPAMLTKFLE LVIRIYEDPK ITRTELTVRM EHAFLIGARA
QDVEMRNRFM AIFDKSLSKT ATARLSYVLT AQNWDTLADS FWLAQASQLL LGAVELNAAA
QLHAEDFRTL PASQLCMIYA KDTREPANMA DDKFDNLIAQ HRRFMNEIAD VKVRDLVEPL
SQLQHIDNTL AHQLWVSVFP IYWSATARDE RIELERGIVT LLTKDYHSRQ IDKRPNVVQS
LLEGAAKAWP SCKIPPHVLK YEAKTYDTWY TSLVQLENAA IKPEMESAKV RESNLDALVD
LYASLQEDDL FYGTWRRRCQ FVETNAALSY EQNGMWDKAQ KMYEAAQIKA RTGVIPFSQG
EYMLWEDHWV LCAQKLQQWD ILQDFAKHEN FQDLLLECAW RNTEMWQDGN QRDALDTLIK
GVMDAPTPRR AFFQSFMALL KFHNKLETHA EFAKSCDEAI QLSIRKWHQL PQQLTKAHIP
LLQNFQQLVE LHDAQVICQS LSSTNQSNLD VKSGELKLLL GAWRDRLPNV WDDITAWQDL
VTWRQHIFGL INQTYLQLLP QQGGNQNTNG ASFAYRGYHE TAWIINRFAH VSRKHNLPDV
CISQLSRIYT LPNIEIQEAF LKLREQAKCH FENPDELTSG LDVINNTNLN YFNPPQKAEF
YTLKGMFLEK LSQKEEADSA YGTALYFDIT AAKAWAEWGY FNERRFKADA NDVNSARQAL
TSYLQAAGSY KNAKSRKLLA RILWLLSLDD ATGTIAAGFD DFKGETPIWY WITYIPQLLT
GLAYKEGPRV HQILTKIAKS YPQALYFQLR TNREDMAVIK KNQEAKERAR QRAQSAANQQ
AAPLPQLREM RPALVKTEGG APKSSSVAPA PADGGTPAPA ATPVPAPTPT PAPASAPVPA
QAAQAQSDQQ QQQSGAGQKK PPWELTEEIM SHLKSAFPLL ALSMETMVDQ IQKHFKCPPD
EDAYRLIVAL LNDALAYVSR MPSSFAKIKL PSATETNITR FAETILPPHI KKSFEADFVQ
TKPTMDDYIY KLRRWRNKFE EKLDRRSTRV SLEAFSPHLS EFRYQRFDDV EIPGQYLEHK
DKNQDFIRIE RFLPNVELVR SISASYRRLK IRGHDASVHS WAVQHPAARH CRREERILQL
FRQLNQTLNR RKESRRRDMQ FTLPLMVPLA PHIRIVQEDT SYITLQGVYE DHCRRNSMKK
DDPVLFTMEK LRGVLDTKNA VCIRGDGHPT DARTDQAQKH GEQTATARLE VFNAIQEKWV
PHTVALEYFQ KIFPSFTDFW LFRRQLSYQM AALTFMTYIL YMHNRYPQKI NIARASGNIW
GSELMSYMSA GKPFFHNPEP VPFRLTPNLQ TLMGPLAMEG IFSCSLMAIA RCLLEGEHEL
ENALTLFVRD EMIFWFTSSH RAVQMTEHQL RESVQVNSDS IVKRATSLAQ SPASNLPANQ
TVIDLIAKAV NPMNLAQCDA LWMPYL
//