ID C9SHQ5_VERA1 Unreviewed; 1100 AA.
AC C9SHQ5;
DT 24-NOV-2009, integrated into UniProtKB/TrEMBL.
DT 24-NOV-2009, sequence version 1.
DT 27-MAR-2024, entry version 80.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN ORFNames=VDBG_04587 {ECO:0000313|EMBL:EEY18478.1};
OS Verticillium alfalfae (strain VaMs.102 / ATCC MYA-4576 / FGSC 10136)
OS (Verticillium wilt of alfalfa) (Verticillium albo-atrum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Glomerellales; Plectosphaerellaceae; Verticillium.
OX NCBI_TaxID=526221 {ECO:0000313|Proteomes:UP000008698};
RN [1] {ECO:0000313|Proteomes:UP000008698}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VaMs.102 / ATCC MYA-4576 / FGSC 10136
RC {ECO:0000313|Proteomes:UP000008698};
RX PubMed=21829347; DOI=10.1371/journal.ppat.1002137;
RA Klosterman S.J., Subbarao K.V., Kang S., Veronese P., Gold S.E.,
RA Thomma B.P.H.J., Chen Z., Henrissat B., Lee Y.-H., Park J.,
RA Garcia-Pedrajas M.D., Barbara D.J., Anchieta A., de Jonge R., Santhanam P.,
RA Maruthachalam K., Atallah Z., Amyotte S.G., Paz Z., Inderbitzin P.,
RA Hayes R.J., Heiman D.I., Young S., Zeng Q., Engels R., Galagan J.,
RA Cuomo C.A., Dobinson K.F., Ma L.-J.;
RT "Comparative genomics yields insights into niche adaptation of plant
RT vascular wilt pathogens.";
RL PLoS Pathog. 7:E1002137-E1002137(2011).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
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DR EMBL; DS985218; EEY18478.1; -; Genomic_DNA.
DR RefSeq; XP_003004981.1; XM_003004935.1.
DR AlphaFoldDB; C9SHQ5; -.
DR SMR; C9SHQ5; -.
DR STRING; 526221.C9SHQ5; -.
DR GeneID; 9530196; -.
DR KEGG; val:VDBG_04587; -.
DR eggNOG; KOG0519; Eukaryota.
DR HOGENOM; CLU_000445_3_2_1; -.
DR OMA; CLAAQMD; -.
DR OrthoDB; 1222064at2759; -.
DR Proteomes; UP000008698; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR CDD; cd06225; HAMP; 4.
DR CDD; cd16922; HATPase_EvgS-ArcB-TorS-like; 1.
DR CDD; cd00082; HisKA; 1.
DR CDD; cd17546; REC_hyHK_CKI1_RcsC-like; 1.
DR Gene3D; 1.10.287.130; -; 1.
DR Gene3D; 1.20.120.1530; -; 4.
DR Gene3D; 3.40.50.2300; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR InterPro; IPR011006; CheY-like_superfamily.
DR InterPro; IPR003660; HAMP_dom.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR003661; HisK_dim/P.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR PANTHER; PTHR45339; HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J; 1.
DR PANTHER; PTHR45339:SF1; HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J; 1.
DR Pfam; PF00672; HAMP; 2.
DR Pfam; PF18947; HAMP_2; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF00512; HisKA; 1.
DR Pfam; PF00072; Response_reg; 1.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM00304; HAMP; 4.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00388; HisKA; 1.
DR SMART; SM00448; REC; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF52172; CheY-like; 2.
DR SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR SUPFAM; SSF58104; Methyl-accepting chemotaxis protein (MCP) signaling domain; 1.
DR PROSITE; PS50885; HAMP; 4.
DR PROSITE; PS50109; HIS_KIN; 1.
DR PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE 4: Predicted;
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:EEY18478.1};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553, ECO:0000256|PROSITE-
KW ProRule:PRU00169}; Reference proteome {ECO:0000313|Proteomes:UP000008698};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 190..245
FT /note="HAMP"
FT /evidence="ECO:0000259|PROSITE:PS50885"
FT DOMAIN 297..349
FT /note="HAMP"
FT /evidence="ECO:0000259|PROSITE:PS50885"
FT DOMAIN 389..441
FT /note="HAMP"
FT /evidence="ECO:0000259|PROSITE:PS50885"
FT DOMAIN 484..536
FT /note="HAMP"
FT /evidence="ECO:0000259|PROSITE:PS50885"
FT DOMAIN 558..753
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
FT DOMAIN 903..1022
FT /note="Response regulatory"
FT /evidence="ECO:0000259|PROSITE:PS50110"
FT REGION 67..123
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1031..1100
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 109..123
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1031..1053
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 952
FT /note="4-aspartylphosphate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00169"
SQ SEQUENCE 1100 AA; 121132 MW; 31C8881954DAF62F CRC64;
MVDDSALAAA AAIVQSFAAD GSTPMSLPFR KDTTRIELPG RDTPAKRSLE LELAKLAQRI
DKLENRAHSA PTAFPETPNE VNDSLFGDDP TGTFPSLGGR VVSRPPLQRE GTQADSGSAG
SPLTDEALES LQEKVLDQEK GISSAREEIT SVSAQLLEQK ELQEQAFSRI EQDRVARLER
ELWKHQKANE AFQKALREIG EIVTAVARGD LSKKVRMNSV EMDPEITTFK RTINTMMDQL
QVFSSEVSRV AREVGTEGLL GGQARIEGVD GTWKELTDNG VKGMWNELTV NVNAMANNLT
TQVRDIIEVT TAVAKGDLTQ KVQADCRGEI FELKSTINSM VDQLQQFARE VTKIAREVGT
EGRLGGQATV HDVEGTWKDL TENVNGMAMN LTTQVREIAR ITTAVAKGDL TKKIGVPAQG
EILDLKNTIN TMVDRLGTFA FEVSKVAREV GTDGTLGGQA QVNNVEGKWK DLTENVNTMA
SNLTLQTTQV RAFSDITNLA TDGDFTKLVE VEASGEMDEL KRKINQMVSN LRDSIQRNTQ
AREAAELANK TKSEFLANMS HEIRTPMNGI IGMTQLTLDT DLTQYQREML NIVNSLANSL
LTIIDDILDL SKIEARRMVI EEIPYTLRGT VFNALKTLAI ILNLVGNAIK FTEHGEVSLT
IKKADELKFP CGPNQYAIEF VVTDTGIGIA ADKLDLIFDT FQQADGSMTR KFGGTGLGLS
ISKRLVKLMG GDLWVKSNHG KGSAFHFTCK VRLCDVGFES IEKQIKPYKG HQVLFVDKTQ
TAYGMEIRDM LGAIGLIPVV VDSEKSPSLD RVRGMAAASM PYDVIIVDSI DTARRLRSVD
DFKYLPIVLL APIVNVRMKA CLDLGITSYM TTPCKAVDLG NGMIPALENR ATPSLADNTK
SFEILLAEDN RVNQRLAVKI LEKYHHVVTV VGNGHEAVEA IKRKRFDVIL MDVQMPIMGG
FEATGKIRDY EREAGSHRTP IIALTAHAMM GDREKCIQAQ MDEYLSKPLQ QNHLIQTILK
CATLGGQLLE KNRERDQPHK KEDADKKTDD SGSSLRPSLE TRAFTSRDPL VGQGLDSPAL
VTADQEDPIS RFHSMRSHST
//
