ID   C9SPX8_VERA1            Unreviewed;       854 AA.
AC   C9SPX8;
DT   24-NOV-2009, integrated into UniProtKB/TrEMBL.
DT   24-NOV-2009, sequence version 1.
DT   27-MAR-2024, entry version 56.
DE   SubName: Full=Guanylate kinase {ECO:0000313|EMBL:EEY20903.1};
GN   ORFNames=VDBG_07013 {ECO:0000313|EMBL:EEY20903.1};
OS   Verticillium alfalfae (strain VaMs.102 / ATCC MYA-4576 / FGSC 10136)
OS   (Verticillium wilt of alfalfa) (Verticillium albo-atrum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Glomerellales; Plectosphaerellaceae; Verticillium.
OX   NCBI_TaxID=526221 {ECO:0000313|Proteomes:UP000008698};
RN   [1] {ECO:0000313|Proteomes:UP000008698}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=VaMs.102 / ATCC MYA-4576 / FGSC 10136
RC   {ECO:0000313|Proteomes:UP000008698};
RX   PubMed=21829347; DOI=10.1371/journal.ppat.1002137;
RA   Klosterman S.J., Subbarao K.V., Kang S., Veronese P., Gold S.E.,
RA   Thomma B.P.H.J., Chen Z., Henrissat B., Lee Y.-H., Park J.,
RA   Garcia-Pedrajas M.D., Barbara D.J., Anchieta A., de Jonge R., Santhanam P.,
RA   Maruthachalam K., Atallah Z., Amyotte S.G., Paz Z., Inderbitzin P.,
RA   Hayes R.J., Heiman D.I., Young S., Zeng Q., Engels R., Galagan J.,
RA   Cuomo C.A., Dobinson K.F., Ma L.-J.;
RT   "Comparative genomics yields insights into niche adaptation of plant
RT   vascular wilt pathogens.";
RL   PLoS Pathog. 7:E1002137-E1002137(2011).
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DR   EMBL; DS985222; EEY20903.1; -; Genomic_DNA.
DR   RefSeq; XP_003002442.1; XM_003002396.1.
DR   AlphaFoldDB; C9SPX8; -.
DR   STRING; 526221.C9SPX8; -.
DR   GeneID; 9527436; -.
DR   KEGG; val:VDBG_07013; -.
DR   eggNOG; KOG0707; Eukaryota.
DR   eggNOG; KOG2491; Eukaryota.
DR   HOGENOM; CLU_017925_0_0_1; -.
DR   OMA; MMGIMDD; -.
DR   OrthoDB; 5490969at2759; -.
DR   Proteomes; UP000008698; Unassembled WGS sequence.
DR   GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   CDD; cd00071; GMPK; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR008145; GK/Ca_channel_bsu.
DR   InterPro; IPR008144; Guanylate_kin-like_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR021861; THO_THOC1.
DR   PANTHER; PTHR13265:SF0; HPR1; 1.
DR   PANTHER; PTHR13265; THO COMPLEX SUBUNIT 1; 1.
DR   Pfam; PF11957; efThoc1; 1.
DR   Pfam; PF00625; Guanylate_kin; 1.
DR   SMART; SM00072; GuKc; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS50052; GUANYLATE_KINASE_2; 1.
PE   4: Predicted;
KW   Kinase {ECO:0000313|EMBL:EEY20903.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008698};
KW   Transferase {ECO:0000313|EMBL:EEY20903.1}.
FT   DOMAIN          604..782
FT                   /note="Guanylate kinase-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50052"
FT   REGION          305..340
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          786..854
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        789..827
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   854 AA;  94655 MW;  0459F1155208EE27 CRC64;
     MPGTIVSDGR VSTVADVSAV LSDLLDRARG TKPPTIEPAL QKSDLGNDID RITAIFADGR
     GAEATESAAQ QSQDKIRQFA VIETAVRDLF KTLVFNTKIE SPEFVQLWNL FDIVSILSDN
     GSCDPALLFW MVEELLDSQT IAGCRKIFDF LESRRERITS SHFKQKQLVI LRTCNELLRR
     LSRAEDTAFC GRVFIFMFQS FPLGDRSSVN LRGEYHVENV TAYDQSAAPM DPDADKMEVE
     KDAAAGPDAN KQSSQDGAVN ADALYPVFWS LQESFSQPKK LFDMTNLEGF KQGLEATVKA
     FKVVQKEQGS RPPKAADSAV GGTKRKRNHD DQGDQSNAFN PKYLTSQDLF ELEISDLSFR
     RNILVQAYII LEFLLSLSAK AKEKLATIKT QNKSVMYMDQ TLSEEDAKWA SDMKEAVEDG
     LKQGSDGPHY HRMVETVLVR DRNWIRWKME GCPPIELPPL SPETWSKAQD ELYSITRNKR
     MKPPMGSLPL DFMQDEDDEK ALDKLRAPDR YELPELGSFR RKIADDDFEI EMPTNDETKA
     AAIESKASKS WRALRIAARS RLGLFDKISD PEKIDAIFGE IEDPDAVPEP EAAPEQKAVL
     PTDQRPVVIS GPPGVGKSTT TDVLLSRQPG AFAKVVRHTT RKPQDGEVAG RDFLFVDKQT
     FDMQRDGDAL IEYTTIDGDD YGTSRKTIDG IVASGKVPIL HMDQEARSFG FEARFVLLLP
     PNQETMEARL TAAGEREDAV KATGAAVAPY LAEGSILKEG FDEVLVNEKL DATFKALETF
     IYGAEQGVSE PEKTDEKPTE ETEAQTEHKL SEDAPAAAAD KNEDDAVMAD AAPAAEDPDK
     AQEGLGEFKP SAAT
//