ID C9YVK6_STRSW Unreviewed; 478 AA.
AC C9YVK6;
DT 24-NOV-2009, integrated into UniProtKB/TrEMBL.
DT 24-NOV-2009, sequence version 1.
DT 27-MAR-2024, entry version 71.
DE RecName: Full=L-lysine N6-monooxygenase MbtG {ECO:0000256|ARBA:ARBA00016406};
DE EC=1.14.13.59 {ECO:0000256|ARBA:ARBA00013076};
DE AltName: Full=Lysine 6-N-hydroxylase {ECO:0000256|ARBA:ARBA00032738};
DE AltName: Full=Lysine N6-hydroxylase {ECO:0000256|ARBA:ARBA00032493};
DE AltName: Full=Lysine-N-oxygenase {ECO:0000256|ARBA:ARBA00029939};
DE AltName: Full=Mycobactin synthase protein G {ECO:0000256|ARBA:ARBA00031158};
GN OrderedLocusNames=SCAB_68811 {ECO:0000313|EMBL:CBG73877.1};
OS Streptomyces scabiei (strain 87.22).
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=680198 {ECO:0000313|EMBL:CBG73877.1, ECO:0000313|Proteomes:UP000001444};
RN [1] {ECO:0000313|EMBL:CBG73877.1, ECO:0000313|Proteomes:UP000001444}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=87.22 {ECO:0000313|EMBL:CBG73877.1,
RC ECO:0000313|Proteomes:UP000001444};
RX PubMed=20064060; DOI=10.1094/MPMI-23-2-0161;
RA Bignell D.R., Seipke R.F., Huguet-Tapia J.C., Chambers A.H., Parry R.J.,
RA Loria R.;
RT "Streptomyces scabies 87-22 contains a coronafacic acid-like biosynthetic
RT cluster that contributes to plant-microbe interactions.";
RL Mol. Plant Microbe Interact. 23:161-175(2010).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-lysine + NADPH + O2 = H2O + N(6)-hydroxy-L-lysine + NADP(+);
CC Xref=Rhea:RHEA:23228, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379,
CC ChEBI:CHEBI:32551, ChEBI:CHEBI:57783, ChEBI:CHEBI:57820,
CC ChEBI:CHEBI:58349; EC=1.14.13.59;
CC Evidence={ECO:0000256|ARBA:ARBA00000168};
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
CC -!- PATHWAY: Siderophore biosynthesis. {ECO:0000256|ARBA:ARBA00004924}.
CC -!- SIMILARITY: Belongs to the lysine N(6)-hydroxylase/L-ornithine N(5)-
CC oxygenase family. {ECO:0000256|ARBA:ARBA00007588}.
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DR EMBL; FN554889; CBG73877.1; -; Genomic_DNA.
DR RefSeq; WP_013004429.1; NC_013929.1.
DR AlphaFoldDB; C9YVK6; -.
DR STRING; 680198.SCAB_68811; -.
DR GeneID; 24312625; -.
DR KEGG; scb:SCAB_68811; -.
DR eggNOG; COG3486; Bacteria.
DR HOGENOM; CLU_020931_0_0_11; -.
DR Proteomes; UP000001444; Chromosome.
DR GO; GO:0047091; F:L-lysine 6-monooxygenase (NADPH) activity; IEA:UniProtKB-EC.
DR GO; GO:0044249; P:cellular biosynthetic process; IEA:UniProt.
DR GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR025700; Lys/Orn_oxygenase.
DR PANTHER; PTHR42802:SF1; L-ORNITHINE N(5)-MONOOXYGENASE; 1.
DR PANTHER; PTHR42802; MONOOXYGENASE; 1.
DR Pfam; PF13434; Lys_Orn_oxgnase; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 2.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000001444}.
SQ SEQUENCE 478 AA; 53503 MW; B67A5860E6E8813A CRC64;
MSPTPAHDQP DPEAPRDLVG IGIGPANLSL AALAQPLTAL DAVFYEQRPG FDWHPGLLIE
GATLQVPFLA DLVTLADPTS PWSFLNYLRT RDRLFPFYFA ERFHIQRAEY DAYCRWVAEN
LPGLRFGHQV DSVRWNPERD LFEVDHTRLG GDGRTEELGR TYARNIVLGV GTEPHVPEPL
KPLVEAAGVP VVHAADYLDE RDRLLAAGHI TVIGAGQSGA EVFLDLLRHR PPGRERLHWL
GRTEAFAPME YSKLGLEHFT PDYTRYFHAL TEPTRDRLVA AQWQLHKGIG TDTIAAIHDE
LYRRTLDGGW PDTVLTPGVH VRTAGRLATT RVELHLEHSE QGTRSRLTTD AVVLATGYRE
RPLDRVLAGL DPYMRRDHRE RCRVDENFRM ILDPSVTAAD RHVYVQNAEL HTHGVGAPDL
GLAAWRSATI LNTLTGKDPY PLPGRTAFTT FGLEPRPRIP AARQATTPTP LTPLVDVR
//
