ID   CAPD_RICBR              Reviewed;         341 AA.
AC   Q1RIM4;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   16-MAY-2006, sequence version 1.
DT   27-MAR-2024, entry version 95.
DE   RecName: Full=UDP-glucose 4-epimerase;
DE            EC=5.1.3.2;
DE   AltName: Full=Galactowaldenase;
DE   AltName: Full=UDP-galactose 4-epimerase;
GN   Name=capD; OrderedLocusNames=RBE_0709;
OS   Rickettsia bellii (strain RML369-C).
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Rickettsiales;
OC   Rickettsiaceae; Rickettsieae; Rickettsia; belli group.
OX   NCBI_TaxID=336407;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RML369-C;
RX   PubMed=16703114; DOI=10.1371/journal.pgen.0020076;
RA   Ogata H., La Scola B., Audic S., Renesto P., Blanc G., Robert C.,
RA   Fournier P.-E., Claverie J.-M., Raoult D.;
RT   "Genome sequence of Rickettsia bellii illuminates the role of amoebae in
RT   gene exchanges between intracellular pathogens.";
RL   PLoS Genet. 2:733-744(2006).
CC   -!- FUNCTION: Epimerizes UDP-galactose to UDP-glucose. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=UDP-alpha-D-glucose = UDP-alpha-D-galactose;
CC         Xref=Rhea:RHEA:22168, ChEBI:CHEBI:58885, ChEBI:CHEBI:66914;
CC         EC=5.1.3.2;
CC   -!- SIMILARITY: Belongs to the polysaccharide synthase family.
CC       {ECO:0000305}.
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DR   EMBL; CP000087; ABE04790.1; -; Genomic_DNA.
DR   RefSeq; WP_011477377.1; NC_007940.1.
DR   AlphaFoldDB; Q1RIM4; -.
DR   SMR; Q1RIM4; -.
DR   KEGG; rbe:RBE_0709; -.
DR   eggNOG; COG1086; Bacteria.
DR   HOGENOM; CLU_013560_4_1_5; -.
DR   OrthoDB; 9803111at2; -.
DR   Proteomes; UP000001951; Chromosome.
DR   GO; GO:0003978; F:UDP-glucose 4-epimerase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009103; P:lipopolysaccharide biosynthetic process; IEA:UniProtKB-KW.
DR   CDD; cd05237; UDP_invert_4-6DH_SDR_e; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR013692; CapD_C.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR003869; Polysac_CapD-like.
DR   PANTHER; PTHR43318; UDP-N-ACETYLGLUCOSAMINE 4,6-DEHYDRATASE; 1.
DR   PANTHER; PTHR43318:SF2; UDP-N-ACETYLGLUCOSAMINE 4,6-DEHYDRATASE (INVERTING); 1.
DR   Pfam; PF08485; Polysacc_syn_2C; 1.
DR   Pfam; PF02719; Polysacc_synt_2; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   3: Inferred from homology;
KW   Isomerase; Lipopolysaccharide biosynthesis; Reference proteome.
FT   CHAIN           1..341
FT                   /note="UDP-glucose 4-epimerase"
FT                   /id="PRO_0000314601"
SQ   SEQUENCE   341 AA;  38596 MW;  E27CD38C3C5E9FA2 CRC64;
     MFVDKTLLIT GGTGSFGNAV LSRFLKNDII KDIKEIRIFS RDEKKQEDMR IALNNPKIKF
     YIGDVRNYNS IDDAMKGVDY VFHAAALKQV PTCEFYPMEA INTNILGAEN VLRAATINKV
     AKVIVLSTDK AVYPINAMGL SKALMEKLAI AKARMNVRDK TVFCVTRYGN VMASRGSVIP
     LFINQIKQNK DLTITEPSMT RFLMSLVDSV DLVLYAFEYG HQGDIFVQKS PASTIEVLAK
     ALQGIFNSKN KIRFIGTRHG EKHYESLVSS EEMAKAEDLG NYYRIPMDGR DLNYAKYFVE
     GEKKIALLED YTSHNTKRLN LEEVKELLLN LDYVQEELKN A
//