ID CAS5_METJA Reviewed; 245 AA.
AC Q57827;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 27-MAR-2024, entry version 90.
DE RecName: Full=CRISPR-associated protein Cas5;
GN Name=cas5; OrderedLocusNames=MJ0382;
OS Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM
OS 10045 / NBRC 100440) (Methanococcus jannaschii).
OC Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales;
OC Methanocaldococcaceae; Methanocaldococcus.
OX NCBI_TaxID=243232;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440;
RX PubMed=8688087; DOI=10.1126/science.273.5278.1058;
RA Bult C.J., White O., Olsen G.J., Zhou L., Fleischmann R.D., Sutton G.G.,
RA Blake J.A., FitzGerald L.M., Clayton R.A., Gocayne J.D., Kerlavage A.R.,
RA Dougherty B.A., Tomb J.-F., Adams M.D., Reich C.I., Overbeek R.,
RA Kirkness E.F., Weinstock K.G., Merrick J.M., Glodek A., Scott J.L.,
RA Geoghagen N.S.M., Weidman J.F., Fuhrmann J.L., Nguyen D., Utterback T.R.,
RA Kelley J.M., Peterson J.D., Sadow P.W., Hanna M.C., Cotton M.D.,
RA Roberts K.M., Hurst M.A., Kaine B.P., Borodovsky M., Klenk H.-P.,
RA Fraser C.M., Smith H.O., Woese C.R., Venter J.C.;
RT "Complete genome sequence of the methanogenic archaeon, Methanococcus
RT jannaschii.";
RL Science 273:1058-1073(1996).
CC -!- FUNCTION: CRISPR (clustered regularly interspaced short palindromic
CC repeat) is an adaptive immune system that provides protection against
CC mobile genetic elements (viruses, transposable elements and conjugative
CC plasmids). CRISPR clusters contain spacers, sequences complementary to
CC antecedent mobile elements, and target invading nucleic acids. CRISPR
CC clusters are transcribed and processed into CRISPR RNA (crRNA) (By
CC similarity). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the CRISPR-associated protein Cas5 family.
CC Subtype I-A/Apern subfamily. {ECO:0000305}.
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DR EMBL; L77117; AAB98378.1; -; Genomic_DNA.
DR PIR; F64347; F64347.
DR AlphaFoldDB; Q57827; -.
DR SMR; Q57827; -.
DR STRING; 243232.MJ_0382; -.
DR PaxDb; 243232-MJ_0382; -.
DR EnsemblBacteria; AAB98378; AAB98378; MJ_0382.
DR KEGG; mja:MJ_0382; -.
DR eggNOG; arCOG02672; Archaea.
DR HOGENOM; CLU_1056094_0_0_2; -.
DR InParanoid; Q57827; -.
DR Proteomes; UP000000805; Chromosome.
DR GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
DR GO; GO:0043571; P:maintenance of CRISPR repeat elements; IEA:InterPro.
DR CDD; cd09753; Cas5_I-A; 1.
DR Gene3D; 3.30.70.3120; -; 1.
DR InterPro; IPR021124; CRISPR-assoc_prot_Cas5.
DR InterPro; IPR013422; CRISPR-assoc_prot_Cas5_N.
DR InterPro; IPR010153; CRISPR-assoc_prot_Cas5a-typ.
DR NCBIfam; TIGR01874; cas_cas5a; 1.
DR NCBIfam; TIGR02593; CRISPR_cas5; 1.
DR Pfam; PF09704; Cas_Cas5d; 1.
PE 3: Inferred from homology;
KW Antiviral defense; Reference proteome.
FT CHAIN 1..245
FT /note="CRISPR-associated protein Cas5"
FT /id="PRO_0000106845"
SQ SEQUENCE 245 AA; 28255 MW; 6169A4FFC51AE8BA CRC64;
MIMEALVALL RFPFYSFGKQ SYQVRQSLLL PSPSALKGAL AKGIILLGGK KGKSLDEIAK
KTVEELENKL IYVGAKPYKS SIIKTPILLK RLRNLEDQKN PEKSDAMRRE YVFAREILAI
YVFRRKLSEE EKDLMLKAVY LIDQLGDTEC VGNVIKTEWV EVKEEKAPLK TYVKFKKVSK
MSINGGIIEN MLETPNFGNK VKEEPYLLPL IEKRYRRSSY YVESDRIFDG NYKIIAFDEV
IGLWI
//
