ID   CC106_BOVIN             Reviewed;         278 AA.
AC   Q1LZ89;
DT   06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2006, sequence version 1.
DT   24-JAN-2024, entry version 82.
DE   RecName: Full=Coiled-coil domain-containing protein 106;
GN   Name=CCDC106;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Ascending colon;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Promotes the degradation of p53/TP53 protein and inhibits its
CC       transactivity. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with p53/TP53. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Note=Colocalizes with
CC       p53/TP53. {ECO:0000250}.
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DR   EMBL; BC116140; AAI16141.1; -; mRNA.
DR   RefSeq; NP_001073803.1; NM_001080334.1.
DR   RefSeq; XP_010813795.1; XM_010815493.2.
DR   RefSeq; XP_015313871.1; XM_015458385.1.
DR   AlphaFoldDB; Q1LZ89; -.
DR   SMR; Q1LZ89; -.
DR   STRING; 9913.ENSBTAP00000015303; -.
DR   PaxDb; 9913-ENSBTAP00000015303; -.
DR   Ensembl; ENSBTAT00000015303.4; ENSBTAP00000015303.3; ENSBTAG00000011517.4.
DR   GeneID; 618485; -.
DR   KEGG; bta:618485; -.
DR   CTD; 29903; -.
DR   VEuPathDB; HostDB:ENSBTAG00000011517; -.
DR   VGNC; VGNC:26831; CCDC106.
DR   eggNOG; ENOG502RTFM; Eukaryota.
DR   GeneTree; ENSGT00390000013183; -.
DR   HOGENOM; CLU_069155_0_0_1; -.
DR   InParanoid; Q1LZ89; -.
DR   OMA; VMSDTIN; -.
DR   OrthoDB; 4251447at2759; -.
DR   TreeFam; TF331729; -.
DR   Proteomes; UP000009136; Chromosome 18.
DR   Bgee; ENSBTAG00000011517; Expressed in floor plate of diencephalon and 106 other cell types or tissues.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IBA:GO_Central.
DR   InterPro; IPR031591; CCDC106.
DR   PANTHER; PTHR16477; COILED-COIL DOMAIN-CONTAINING PROTEIN 106; 1.
DR   PANTHER; PTHR16477:SF2; COILED-COIL DOMAIN-CONTAINING PROTEIN 106; 1.
DR   Pfam; PF15794; CCDC106; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Nucleus; Phosphoprotein; Reference proteome.
FT   CHAIN           1..278
FT                   /note="Coiled-coil domain-containing protein 106"
FT                   /id="PRO_0000274342"
FT   REGION          102..174
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          61..99
FT                   /evidence="ECO:0000255"
FT   MOTIF           151..164
FT                   /note="Bipartite nuclear localization signal"
FT                   /evidence="ECO:0000250"
FT   COMPBIAS        102..120
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        129..143
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        154..168
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         128
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9BWC9"
SQ   SEQUENCE   278 AA;  31387 MW;  6C441F0F51F7B100 CRC64;
     MNSRRRPVKK DSEALEISIP FDETPHLDPQ IFYSLSPSRG NFEEPSEAAS PTAALMNGVR
     AQLHLALERN SWLQKRIEDL EEERDFLRCQ LDKFISSARL DADDHCRGKP GPRRAEGDGR
     GGTGGEASDP ESAASSLSGA SEEGSTVERK RQKQKGGPGR RRFGKPKARE RQRVKDADGV
     LCRYKKILGT FQKLKSMSRA FEHHRVDRNT VALTTPIAEL LIVAPEKLAE VGEFDPSKER
     LLEYSRRCFL ALDEETLKKV QALKKSKLLL PITYRFKR
//