ID CC74B_HUMAN Reviewed; 380 AA.
AC Q96LY2; Q6NW18;
DT 06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 24-JAN-2024, entry version 130.
DE RecName: Full=Coiled-coil domain-containing protein 74B;
GN Name=CCDC74B;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Trachea;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q96LY2-2; Q9NYB9-2: ABI2; NbExp=3; IntAct=EBI-17967022, EBI-11096309;
CC Q96LY2-2; Q8N9N5-2: BANP; NbExp=3; IntAct=EBI-17967022, EBI-11524452;
CC Q96LY2-2; Q5T8I9: HENMT1; NbExp=3; IntAct=EBI-17967022, EBI-9675710;
CC Q96LY2-2; Q8TAP4-4: LMO3; NbExp=3; IntAct=EBI-17967022, EBI-11742507;
CC Q96LY2-2; P40692: MLH1; NbExp=3; IntAct=EBI-17967022, EBI-744248;
CC Q96LY2-2; P17252: PRKCA; NbExp=3; IntAct=EBI-17967022, EBI-1383528;
CC Q96LY2-2; Q9BWG6: SCNM1; NbExp=3; IntAct=EBI-17967022, EBI-748391;
CC Q96LY2-2; Q15047-2: SETDB1; NbExp=3; IntAct=EBI-17967022, EBI-9090795;
CC Q96LY2-2; Q8TF42: UBASH3B; NbExp=3; IntAct=EBI-17967022, EBI-1380492;
CC Q96LY2-2; P61981: YWHAG; NbExp=3; IntAct=EBI-17967022, EBI-359832;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q96LY2-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q96LY2-2; Sequence=VSP_022730;
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DR EMBL; AK057609; BAB71533.1; -; mRNA.
DR EMBL; BC067771; AAH67771.1; -; mRNA.
DR CCDS; CCDS2155.1; -. [Q96LY2-1]
DR CCDS; CCDS58726.1; -. [Q96LY2-2]
DR RefSeq; NP_001245236.1; NM_001258307.1. [Q96LY2-2]
DR RefSeq; NP_997193.1; NM_207310.2. [Q96LY2-1]
DR AlphaFoldDB; Q96LY2; -.
DR SMR; Q96LY2; -.
DR BioGRID; 124829; 32.
DR IntAct; Q96LY2; 33.
DR MINT; Q96LY2; -.
DR STRING; 9606.ENSP00000308873; -.
DR iPTMnet; Q96LY2; -.
DR PhosphoSitePlus; Q96LY2; -.
DR BioMuta; CCDC74B; -.
DR DMDM; 74732259; -.
DR MassIVE; Q96LY2; -.
DR PaxDb; 9606-ENSP00000308873; -.
DR PeptideAtlas; Q96LY2; -.
DR Antibodypedia; 56078; 49 antibodies from 12 providers.
DR DNASU; 91409; -.
DR Ensembl; ENST00000310463.10; ENSP00000308873.6; ENSG00000152076.19. [Q96LY2-1]
DR Ensembl; ENST00000409943.8; ENSP00000386294.3; ENSG00000152076.19. [Q96LY2-2]
DR GeneID; 91409; -.
DR KEGG; hsa:91409; -.
DR MANE-Select; ENST00000409943.8; ENSP00000386294.3; NM_001258307.2; NP_001245236.1. [Q96LY2-2]
DR UCSC; uc002tqm.3; human. [Q96LY2-1]
DR AGR; HGNC:25267; -.
DR CTD; 91409; -.
DR GeneCards; CCDC74B; -.
DR HGNC; HGNC:25267; CCDC74B.
DR HPA; ENSG00000152076; Tissue enhanced (testis).
DR neXtProt; NX_Q96LY2; -.
DR OpenTargets; ENSG00000152076; -.
DR PharmGKB; PA143485426; -.
DR VEuPathDB; HostDB:ENSG00000152076; -.
DR eggNOG; ENOG502S5P9; Eukaryota.
DR GeneTree; ENSGT00390000007249; -.
DR HOGENOM; CLU_844571_0_0_1; -.
DR InParanoid; Q96LY2; -.
DR OMA; RNARSPC; -.
DR OrthoDB; 5389188at2759; -.
DR PhylomeDB; Q96LY2; -.
DR TreeFam; TF329669; -.
DR PathwayCommons; Q96LY2; -.
DR SignaLink; Q96LY2; -.
DR BioGRID-ORCS; 91409; 33 hits in 1074 CRISPR screens.
DR ChiTaRS; CCDC74B; human.
DR GenomeRNAi; 91409; -.
DR Pharos; Q96LY2; Tdark.
DR PRO; PR:Q96LY2; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; Q96LY2; Protein.
DR Bgee; ENSG00000152076; Expressed in right uterine tube and 98 other cell types or tissues.
DR ExpressionAtlas; Q96LY2; baseline and differential.
DR Genevisible; Q96LY2; HS.
DR InterPro; IPR029422; CCDC74_C.
DR InterPro; IPR040370; CCDC74A/CCDC74B/CCDC92.
DR InterPro; IPR039496; CCDC92/74_N.
DR PANTHER; PTHR14882; COILED-COIL DOMAIN-CONTAINING 74A; 1.
DR PANTHER; PTHR14882:SF7; COILED-COIL DOMAIN-CONTAINING PROTEIN 74A-RELATED; 1.
DR Pfam; PF14917; CCDC74_C; 1.
DR Pfam; PF14916; CCDC92; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Coiled coil; Reference proteome.
FT CHAIN 1..380
FT /note="Coiled-coil domain-containing protein 74B"
FT /id="PRO_0000274375"
FT REGION 1..51
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 89..108
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 128..202
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 47..93
FT /evidence="ECO:0000255"
FT COMPBIAS 13..46
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 89..103
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 161..197
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 100..165
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_022730"
FT VARIANT 169
FT /note="T -> M (in dbSNP:rs184349150)"
FT /id="VAR_030269"
FT VARIANT 346
FT /note="R -> H (in dbSNP:rs3177472)"
FT /id="VAR_030270"
SQ SEQUENCE 380 AA; 41826 MW; 2B18E643CEB9E242 CRC64;
MSGAGVAAGT RPPSSPTPGS RRRRQRPSVG VQSLRPQSPQ LRQSDPQKRN LDLEKSLQFL
QQQHSEMLAK LHEEIEHLKR ENKDLRYKLI MNQTSQKKDG PSGNHLSRAS APLGARWVCI
NGVWVEPGGP SPARLKEGSS RTHRPGGKHG RLAGGSADTV RSPADSLSTS SFQSVKSISN
SGKARPQPGS FNKQDSKADV PQKADLEEEP LLHNSKLDKV PGVQGQARKE KAEASNAGAA
CMGNSQHQGR QMGAAAHPPM ILPLPLRKPT TLRQCEVLIR ELWNTNLLQT QELQHLKSLL
EGSQRPQAVP EEASFPRDQE ATHFPKVSTK SLSKKCLLLS PPVAERAILP ALKQTPKNNF
AERQKRLQAM QKRRLHRSVL
//
