ID CCL5_RAT Reviewed; 92 AA.
AC P50231;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 24-JAN-2024, entry version 135.
DE RecName: Full=C-C motif chemokine 5;
DE AltName: Full=SIS-delta;
DE AltName: Full=Small-inducible cytokine A5;
DE AltName: Full=T-cell-specific protein RANTES;
DE Flags: Precursor;
GN Name=Ccl5; Synonyms=Scya5;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Long Evans; TISSUE=Lung;
RA Jones M.L., Shanley T.P., Ward P.A.;
RL Submitted (FEB-1994) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Chemoattractant for blood monocytes, memory T-helper cells
CC and eosinophils. Causes the release of histamine from basophils and
CC activates eosinophils. May activate several chemokine receptors
CC including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G
CC protein-coupled receptor GPR75. Together with GPR75, may play a role in
CC neuron survival through activation of a downstream signaling pathway
CC involving the PI3, Akt and MAP kinases. By activating GPR75 may also
CC play a role in insulin secretion by islet cells.
CC {ECO:0000250|UniProtKB:P13501}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- SIMILARITY: Belongs to the intercrine beta (chemokine CC) family.
CC {ECO:0000305}.
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DR EMBL; U06436; AAA96499.1; -; mRNA.
DR AlphaFoldDB; P50231; -.
DR SMR; P50231; -.
DR STRING; 10116.ENSRNOP00000014865; -.
DR PhosphoSitePlus; P50231; -.
DR PaxDb; 10116-ENSRNOP00000014865; -.
DR AGR; RGD:69069; -.
DR RGD; 69069; Ccl5.
DR eggNOG; ENOG502S8D1; Eukaryota.
DR InParanoid; P50231; -.
DR PhylomeDB; P50231; -.
DR Reactome; R-RNO-380108; Chemokine receptors bind chemokines.
DR Reactome; R-RNO-418594; G alpha (i) signalling events.
DR PRO; PR:P50231; -.
DR Proteomes; UP000002494; Unplaced.
DR GO; GO:0005737; C:cytoplasm; ISO:RGD.
DR GO; GO:0005615; C:extracellular space; IDA:RGD.
DR GO; GO:0048020; F:CCR chemokine receptor binding; IBA:GO_Central.
DR GO; GO:0031726; F:CCR1 chemokine receptor binding; ISO:RGD.
DR GO; GO:0031730; F:CCR5 chemokine receptor binding; ISO:RGD.
DR GO; GO:0042056; F:chemoattractant activity; ISO:RGD.
DR GO; GO:0008009; F:chemokine activity; IDA:RGD.
DR GO; GO:0046817; F:chemokine receptor antagonist activity; ISO:RGD.
DR GO; GO:0042379; F:chemokine receptor binding; ISO:RGD.
DR GO; GO:0008201; F:heparin binding; IDA:RGD.
DR GO; GO:0042802; F:identical protein binding; ISO:RGD.
DR GO; GO:0004435; F:phosphatidylinositol phospholipase C activity; ISO:RGD.
DR GO; GO:0016004; F:phospholipase activator activity; ISO:RGD.
DR GO; GO:0042803; F:protein homodimerization activity; ISO:RGD.
DR GO; GO:0004672; F:protein kinase activity; ISO:RGD.
DR GO; GO:0043621; F:protein self-association; ISO:RGD.
DR GO; GO:0030298; F:receptor signaling protein tyrosine kinase activator activity; ISO:RGD.
DR GO; GO:0006816; P:calcium ion transport; ISO:RGD.
DR GO; GO:0007267; P:cell-cell signaling; ISO:RGD.
DR GO; GO:0071448; P:cellular response to alkyl hydroperoxide; IEP:RGD.
DR GO; GO:0071230; P:cellular response to amino acid stimulus; IEP:RGD.
DR GO; GO:0071345; P:cellular response to cytokine stimulus; IEP:RGD.
DR GO; GO:0071361; P:cellular response to ethanol; IEP:RGD.
DR GO; GO:0044344; P:cellular response to fibroblast growth factor stimulus; ISO:RGD.
DR GO; GO:0071403; P:cellular response to high density lipoprotein particle stimulus; IEP:RGD.
DR GO; GO:0071347; P:cellular response to interleukin-1; ISO:RGD.
DR GO; GO:0071396; P:cellular response to lipid; IEP:RGD.
DR GO; GO:0071222; P:cellular response to lipopolysaccharide; IEP:RGD.
DR GO; GO:0071315; P:cellular response to morphine; IEP:RGD.
DR GO; GO:0071560; P:cellular response to transforming growth factor beta stimulus; IEP:RGD.
DR GO; GO:0071356; P:cellular response to tumor necrosis factor; IEP:RGD.
DR GO; GO:0071346; P:cellular response to type II interferon; ISO:RGD.
DR GO; GO:0071307; P:cellular response to vitamin K; IEP:RGD.
DR GO; GO:0070098; P:chemokine-mediated signaling pathway; ISS:UniProtKB.
DR GO; GO:0002544; P:chronic inflammatory response; IEP:RGD.
DR GO; GO:0018894; P:dibenzo-p-dioxin metabolic process; IEP:RGD.
DR GO; GO:0048245; P:eosinophil chemotaxis; ISO:RGD.
DR GO; GO:0050673; P:epithelial cell proliferation; ISO:RGD.
DR GO; GO:0006887; P:exocytosis; ISO:RGD.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; ISS:UniProtKB.
DR GO; GO:0006954; P:inflammatory response; ISO:RGD.
DR GO; GO:0006874; P:intracellular calcium ion homeostasis; ISO:RGD.
DR GO; GO:0007159; P:leukocyte cell-cell adhesion; ISO:RGD.
DR GO; GO:0048247; P:lymphocyte chemotaxis; IDA:RGD.
DR GO; GO:0002548; P:monocyte chemotaxis; IBA:GO_Central.
DR GO; GO:0045744; P:negative regulation of G protein-coupled receptor signaling pathway; ISO:RGD.
DR GO; GO:2000110; P:negative regulation of macrophage apoptotic process; ISO:RGD.
DR GO; GO:0070233; P:negative regulation of T cell apoptotic process; ISO:RGD.
DR GO; GO:0045071; P:negative regulation of viral genome replication; ISO:RGD.
DR GO; GO:0042119; P:neutrophil activation; ISO:RGD.
DR GO; GO:0030593; P:neutrophil chemotaxis; IBA:GO_Central.
DR GO; GO:0045766; P:positive regulation of angiogenesis; IMP:RGD.
DR GO; GO:0051928; P:positive regulation of calcium ion transport; ISO:RGD.
DR GO; GO:0045785; P:positive regulation of cell adhesion; ISO:RGD.
DR GO; GO:0030335; P:positive regulation of cell migration; ISO:RGD.
DR GO; GO:0033634; P:positive regulation of cell-cell adhesion mediated by integrin; ISO:RGD.
DR GO; GO:0031328; P:positive regulation of cellular biosynthetic process; ISO:RGD.
DR GO; GO:0050679; P:positive regulation of epithelial cell proliferation; ISO:RGD.
DR GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IBA:GO_Central.
DR GO; GO:0031622; P:positive regulation of fever generation; IDA:RGD.
DR GO; GO:0010628; P:positive regulation of gene expression; IDA:RGD.
DR GO; GO:0034112; P:positive regulation of homotypic cell-cell adhesion; ISO:RGD.
DR GO; GO:0010759; P:positive regulation of macrophage chemotaxis; ISO:RGD.
DR GO; GO:0060754; P:positive regulation of mast cell chemotaxis; IDA:RGD.
DR GO; GO:0090026; P:positive regulation of monocyte chemotaxis; ISO:RGD.
DR GO; GO:2000503; P:positive regulation of natural killer cell chemotaxis; ISO:RGD.
DR GO; GO:0045666; P:positive regulation of neuron differentiation; IMP:RGD.
DR GO; GO:0045672; P:positive regulation of osteoclast differentiation; IDA:RGD.
DR GO; GO:0051897; P:positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; IDA:BHF-UCL.
DR GO; GO:0042327; P:positive regulation of phosphorylation; ISO:RGD.
DR GO; GO:0014911; P:positive regulation of smooth muscle cell migration; ISO:RGD.
DR GO; GO:0048661; P:positive regulation of smooth muscle cell proliferation; ISO:RGD.
DR GO; GO:0070234; P:positive regulation of T cell apoptotic process; ISO:RGD.
DR GO; GO:0010820; P:positive regulation of T cell chemotaxis; IDA:BHF-UCL.
DR GO; GO:2000406; P:positive regulation of T cell migration; ISO:RGD.
DR GO; GO:0042102; P:positive regulation of T cell proliferation; ISO:RGD.
DR GO; GO:0042531; P:positive regulation of tyrosine phosphorylation of STAT protein; ISO:RGD.
DR GO; GO:0031269; P:pseudopodium assembly; IDA:BHF-UCL.
DR GO; GO:0050796; P:regulation of insulin secretion; ISS:UniProtKB.
DR GO; GO:0043067; P:regulation of programmed cell death; IMP:RGD.
DR GO; GO:0050863; P:regulation of T cell activation; ISO:RGD.
DR GO; GO:0014823; P:response to activity; IEP:RGD.
DR GO; GO:0097305; P:response to alcohol; IEP:RGD.
DR GO; GO:0009617; P:response to bacterium; IEP:RGD.
DR GO; GO:0070723; P:response to cholesterol; IEP:RGD.
DR GO; GO:0034097; P:response to cytokine; IEP:RGD.
DR GO; GO:0043627; P:response to estrogen; IEP:RGD.
DR GO; GO:0051384; P:response to glucocorticoid; IEP:RGD.
DR GO; GO:0032868; P:response to insulin; IEP:RGD.
DR GO; GO:0032496; P:response to lipopolysaccharide; IEP:RGD.
DR GO; GO:0031667; P:response to nutrient levels; IEP:RGD.
DR GO; GO:0014070; P:response to organic cyclic compound; IEP:RGD.
DR GO; GO:0009651; P:response to salt stress; IEP:RGD.
DR GO; GO:0009636; P:response to toxic substance; ISO:RGD.
DR GO; GO:0034612; P:response to tumor necrosis factor; ISO:RGD.
DR GO; GO:0034341; P:response to type II interferon; IDA:BHF-UCL.
DR GO; GO:0009410; P:response to xenobiotic stimulus; IEP:RGD.
DR GO; GO:0035688; P:T-helper 1 cell diapedesis; IDA:BHF-UCL.
DR CDD; cd00272; Chemokine_CC; 1.
DR Gene3D; 2.40.50.40; -; 1.
DR InterPro; IPR039809; Chemokine_b/g/d.
DR InterPro; IPR000827; Chemokine_CC_CS.
DR InterPro; IPR001811; Chemokine_IL8-like_dom.
DR InterPro; IPR036048; Interleukin_8-like_sf.
DR PANTHER; PTHR12015:SF170; C-C MOTIF CHEMOKINE 5; 1.
DR PANTHER; PTHR12015; SMALL INDUCIBLE CYTOKINE A; 1.
DR Pfam; PF00048; IL8; 1.
DR SMART; SM00199; SCY; 1.
DR SUPFAM; SSF54117; Interleukin 8-like chemokines; 1.
DR PROSITE; PS00472; SMALL_CYTOKINES_CC; 1.
PE 3: Inferred from homology;
KW Chemotaxis; Cytokine; Disulfide bond; Inflammatory response;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..24
FT /evidence="ECO:0000255"
FT CHAIN 25..92
FT /note="C-C motif chemokine 5"
FT /id="PRO_0000005180"
FT DISULFID 34..58
FT /evidence="ECO:0000250"
FT DISULFID 35..74
FT /evidence="ECO:0000250"
SQ SEQUENCE 92 AA; 10170 MW; B4FBEC2B4208ABC6 CRC64;
MKISAAASLT VILVAAALCT PVPASPYGSD TTPCCFAYLS LALPRAHVKE YFYTSSKCSN
LAVVFVTRRN RQVCANPEKK WVQEYINYLE MS
//
