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Database: UniProt
Entry: CD52_MOUSE
LinkDB: CD52_MOUSE
Original site: CD52_MOUSE 
ID   CD52_MOUSE              Reviewed;          74 AA.
AC   Q64389;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   13-NOV-2019, entry version 115.
DE   RecName: Full=CAMPATH-1 antigen;
DE   AltName: Full=Lymphocyte differentiation antigen B7;
DE   AltName: CD_antigen=CD52;
DE   Flags: Precursor;
GN   Name=Cd52; Synonyms=Cdw52, Mb7;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
OC   Muroidea; Muridae; Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=2147207;
RA   Kubota H., Okazaki H., Onuma M., Kano S., Hattori M., Minato N.;
RT   "Identification and gene cloning of a new phosphatidylinositol-linked
RT   antigen expressed on mature lymphocytes. Down-regulation by lymphocyte
RT   activation.";
RL   J. Immunol. 145:3924-3931(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Epididymis;
RX   PubMed=7515288; DOI=10.1095/biolreprod50.4.896;
RA   Kirchhoff C.;
RT   "A major messenger ribonucleic acid of the rodent epididymis encodes a
RT   small glycosylphosphatidylinositol-anchored lymphocyte surface
RT   antigen.";
RL   Biol. Reprod. 50:896-902(1994).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=NOD; TISSUE=Thymus;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
RA   Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
RA   Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
RA   Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
RA   Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
RA   Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
RA   di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
RA   Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
RA   Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
RA   Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
RA   Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
RA   Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
RA   Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
RA   Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
RA   Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
RA   Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
RA   Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
RA   Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
RA   Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
RA   Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
RA   Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
RA   Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
RA   Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
RA   Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
RA   Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
RA   Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
RA   Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
RA   Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
RA   Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
RA   Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
RA   Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
RA   Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Mammary gland;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: May play a role in carrying and orienting carbohydrate,
CC       as well as having a more specific role.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor.
CC   -!- TISSUE SPECIFICITY: Expressed on lymphohematopoietic tissues,
CC       including thymus, spleen, and bone marrow, but not in liver,
CC       kidney, and brain.
DR   EMBL; M55561; AAA39889.1; -; mRNA.
DR   EMBL; X76696; CAA54125.1; -; mRNA.
DR   EMBL; AK088161; BAC40183.1; -; mRNA.
DR   EMBL; BC027495; AAH27495.1; -; mRNA.
DR   CCDS; CCDS38909.1; -.
DR   PIR; I48263; I48263.
DR   RefSeq; NP_038734.1; NM_013706.2.
DR   IntAct; Q64389; 2.
DR   STRING; 10090.ENSMUSP00000000696; -.
DR   PaxDb; Q64389; -.
DR   PRIDE; Q64389; -.
DR   Ensembl; ENSMUST00000000696; ENSMUSP00000000696; ENSMUSG00000000682.
DR   GeneID; 23833; -.
DR   KEGG; mmu:23833; -.
DR   UCSC; uc008vea.2; mouse.
DR   CTD; 1043; -.
DR   MGI; MGI:1346088; Cd52.
DR   GeneTree; ENSGT00860000134004; -.
DR   HOGENOM; HOG000111489; -.
DR   InParanoid; Q64389; -.
DR   KO; K06488; -.
DR   OMA; LVMIQIQ; -.
DR   OrthoDB; 1646255at2759; -.
DR   TreeFam; TF338573; -.
DR   Reactome; R-MMU-163125; Post-translational modification: synthesis of GPI-anchored proteins.
DR   ChiTaRS; Cd52; mouse.
DR   PRO; PR:Q64389; -.
DR   Proteomes; UP000000589; Chromosome 4.
DR   Bgee; ENSMUSG00000000682; Expressed in 176 organ(s), highest expression level in seminal vesicle.
DR   Genevisible; Q64389; MM.
DR   GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0097225; C:sperm midpiece; IDA:MGI.
DR   GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; IBA:GO_Central.
DR   GO; GO:0009617; P:response to bacterium; IEP:MGI.
DR   InterPro; IPR026643; CAMPATH-1.
DR   PANTHER; PTHR15029; PTHR15029; 1.
DR   Pfam; PF15116; CD52; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Complete proteome; Glycoprotein; GPI-anchor;
KW   Lipoprotein; Membrane; Reference proteome; Signal.
FT   SIGNAL        1     23       {ECO:0000255}.
FT   PEPTIDE      24     47       CAMPATH-1 antigen.
FT                                /FTId=PRO_0000020908.
FT   PROPEP       48     74       Removed in mature form. {ECO:0000255}.
FT                                /FTId=PRO_0000020909.
FT   LIPID        47     47       GPI-anchor amidated serine.
FT                                {ECO:0000255}.
FT   CARBOHYD     36     36       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
SQ   SEQUENCE   74 AA;  7798 MW;  E106F479AC481925 CRC64;
     MKSFLLFLTI ILLVVIQIQT GSLGQATTAA SGTNKNSTST KKTPLKSGAS SIIDAGACSF
     LFFANTLMCL FYLS
//
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