ID CDC61_HALSA Reviewed; 308 AA.
AC Q9HHZ9;
DT 14-MAY-2014, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 27-MAR-2024, entry version 134.
DE RecName: Full=ORC1-type DNA replication protein 1;
GN Name=orc1; OrderedLocusNames=VNG_6150G;
OS Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)
OS (Halobacterium halobium).
OG Plasmid pNRC200.
OC Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC Halobacteriaceae; Halobacterium; Halobacterium salinarum NRC-34001.
OX NCBI_TaxID=64091;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700922 / JCM 11081 / NRC-1; PLASMID=pNRC200;
RX PubMed=11016950; DOI=10.1073/pnas.190337797;
RA Ng W.V., Kennedy S.P., Mahairas G.G., Berquist B., Pan M., Shukla H.D.,
RA Lasky S.R., Baliga N.S., Thorsson V., Sbrogna J., Swartzell S., Weir D.,
RA Hall J., Dahl T.A., Welti R., Goo Y.A., Leithauser B., Keller K., Cruz R.,
RA Danson M.J., Hough D.W., Maddocks D.G., Jablonski P.E., Krebs M.P.,
RA Angevine C.M., Dale H., Isenbarger T.A., Peck R.F., Pohlschroder M.,
RA Spudich J.L., Jung K.-H., Alam M., Freitas T., Hou S., Daniels C.J.,
RA Dennis P.P., Omer A.D., Ebhardt H., Lowe T.M., Liang P., Riley M., Hood L.,
RA DasSarma S.;
RT "Genome sequence of Halobacterium species NRC-1.";
RL Proc. Natl. Acad. Sci. U.S.A. 97:12176-12181(2000).
RN [2]
RP DISRUPTION PHENOTYPE.
RC STRAIN=ATCC 700922 / JCM 11081 / NRC-1;
RX PubMed=17559652; DOI=10.1186/1471-2156-8-31;
RA Berquist B.R., DasSarma P., DasSarma S.;
RT "Essential and non-essential DNA replication genes in the model halophilic
RT Archaeon, Halobacterium sp. NRC-1.";
RL BMC Genet. 8:31-31(2007).
CC -!- FUNCTION: Involved in regulation of DNA replication. {ECO:0000250}.
CC -!- DISRUPTION PHENOTYPE: Not essential for normal growth.
CC {ECO:0000269|PubMed:17559652}.
CC -!- SIMILARITY: Belongs to the CDC6/cdc18 family. {ECO:0000305}.
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DR EMBL; AE004438; AAG20823.1; -; Genomic_DNA.
DR RefSeq; WP_010904037.1; NZ_BK010831.1.
DR AlphaFoldDB; Q9HHZ9; -.
DR SMR; Q9HHZ9; -.
DR GeneID; 68695353; -.
DR KEGG; hal:VNG_6150G; -.
DR PATRIC; fig|64091.14.peg.2182; -.
DR HOGENOM; CLU_025112_0_0_2; -.
DR InParanoid; Q9HHZ9; -.
DR OrthoDB; 270161at2157; -.
DR PhylomeDB; Q9HHZ9; -.
DR Proteomes; UP000000554; Plasmid pNRC200.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR CDD; cd18139; HLD_clamp_RarA; 1.
DR Gene3D; 1.10.8.60; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR014277; Orc1/Cdc6_arc.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR02928; orc1/cdc6 family replication initiation protein; 1.
DR PANTHER; PTHR10763; CELL DIVISION CONTROL PROTEIN 6-RELATED; 1.
DR PANTHER; PTHR10763:SF22; ORC1-TYPE DNA REPLICATION PROTEIN 3; 1.
DR Pfam; PF13401; AAA_22; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW ATP-binding; DNA replication; Nucleotide-binding; Plasmid;
KW Reference proteome.
FT CHAIN 1..308
FT /note="ORC1-type DNA replication protein 1"
FT /id="PRO_0000428863"
FT BINDING 51..55
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000250"
FT BINDING 183
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000250"
FT BINDING 195
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000250"
SQ SEQUENCE 308 AA; 35315 MW; 3A22C07CA5AE2F2E CRC64;
MITDARVLQP EFIPREVQHR DAEVNYLSSV LNPLTKGERA DSALLYGPSG VGKTCIAQFL
VEQLRGEVVA LNYQYVNCWE DHSRFQTLYR LLDGIGKTVD IHRQSTPTDV HLNRLRTADD
TSYVVILDEV DQLEDKSLLY DLYRIPHITM ILIANDEEDL FASLDQRLNS RLTDCERIHF
DPYHENELIP ILHDRVHWGL EEDVISDSHL QLIAANAGGD ARVVIGILRH SARTARETGS
DQITADLIEE VTPEAKSEIK QRTVDRFTPH QELLYNIITE HGEISPQDLY DAYCTRTDDP
KTKRMVRN
//
