ID CDC6A_HALSA Reviewed; 413 AA.
AC Q9HSW6;
DT 19-SEP-2002, integrated into UniProtKB/Swiss-Prot.
DT 19-SEP-2002, sequence version 2.
DT 27-MAR-2024, entry version 117.
DE RecName: Full=ORC1-type DNA replication protein 10 {ECO:0000255|HAMAP-Rule:MF_01407};
GN Name=orc10; OrderedLocusNames=VNG_0045C;
OS Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)
OS (Halobacterium halobium).
OC Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC Halobacteriaceae; Halobacterium; Halobacterium salinarum NRC-34001.
OX NCBI_TaxID=64091;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700922 / JCM 11081 / NRC-1;
RX PubMed=11016950; DOI=10.1073/pnas.190337797;
RA Ng W.V., Kennedy S.P., Mahairas G.G., Berquist B., Pan M., Shukla H.D.,
RA Lasky S.R., Baliga N.S., Thorsson V., Sbrogna J., Swartzell S., Weir D.,
RA Hall J., Dahl T.A., Welti R., Goo Y.A., Leithauser B., Keller K., Cruz R.,
RA Danson M.J., Hough D.W., Maddocks D.G., Jablonski P.E., Krebs M.P.,
RA Angevine C.M., Dale H., Isenbarger T.A., Peck R.F., Pohlschroder M.,
RA Spudich J.L., Jung K.-H., Alam M., Freitas T., Hou S., Daniels C.J.,
RA Dennis P.P., Omer A.D., Ebhardt H., Lowe T.M., Liang P., Riley M., Hood L.,
RA DasSarma S.;
RT "Genome sequence of Halobacterium species NRC-1.";
RL Proc. Natl. Acad. Sci. U.S.A. 97:12176-12181(2000).
RN [2]
RP DISRUPTION PHENOTYPE.
RC STRAIN=ATCC 700922 / JCM 11081 / NRC-1;
RX PubMed=17559652; DOI=10.1186/1471-2156-8-31;
RA Berquist B.R., DasSarma P., DasSarma S.;
RT "Essential and non-essential DNA replication genes in the model halophilic
RT Archaeon, Halobacterium sp. NRC-1.";
RL BMC Genet. 8:31-31(2007).
CC -!- FUNCTION: Involved in regulation of DNA replication.
CC {ECO:0000255|HAMAP-Rule:MF_01407}.
CC -!- DISRUPTION PHENOTYPE: Essential for normal growth.
CC {ECO:0000269|PubMed:17559652}.
CC -!- SIMILARITY: Belongs to the CDC6/cdc18 family. {ECO:0000255|HAMAP-
CC Rule:MF_01407}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAG18684.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AE004437; AAG18684.1; ALT_INIT; Genomic_DNA.
DR PIR; H84164; H84164.
DR AlphaFoldDB; Q9HSW6; -.
DR SMR; Q9HSW6; -.
DR STRING; 64091.VNG_0045C; -.
DR PaxDb; 64091-VNG_0045C; -.
DR KEGG; hal:VNG_0045C; -.
DR PATRIC; fig|64091.14.peg.26; -.
DR HOGENOM; CLU_025112_3_1_2; -.
DR InParanoid; Q9HSW6; -.
DR Proteomes; UP000000554; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-UniRule.
DR CDD; cd08768; Cdc6_C; 1.
DR Gene3D; 1.10.8.60; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR HAMAP; MF_01407; ORC1_type_DNA_replic_protein; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR015163; Cdc6_C.
DR InterPro; IPR014277; Orc1/Cdc6_arc.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR NCBIfam; TIGR02928; orc1/cdc6 family replication initiation protein; 1.
DR PANTHER; PTHR10763; CELL DIVISION CONTROL PROTEIN 6-RELATED; 1.
DR PANTHER; PTHR10763:SF22; ORC1-TYPE DNA REPLICATION PROTEIN 3; 1.
DR Pfam; PF13401; AAA_22; 1.
DR Pfam; PF09079; Cdc6_C; 1.
DR SMART; SM00382; AAA; 1.
DR SMART; SM01074; Cdc6_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
PE 3: Inferred from homology;
KW ATP-binding; DNA replication; Nucleotide-binding; Reference proteome.
FT CHAIN 1..413
FT /note="ORC1-type DNA replication protein 10"
FT /id="PRO_0000150996"
FT BINDING 63..67
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01407"
FT BINDING 211
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01407"
FT BINDING 223
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01407"
SQ SEQUENCE 413 AA; 45833 MW; DAA7AC49C8257FCE CRC64;
MLSMPSFERK QNIFANKDAL GESYQPNKIE ERDDEIEKYM DALQPVIDGW EPNNIFVYGN
TGVGKTAVTD HLLDQLQTDV EAYDDVTLSV IYLNCKTLSS SYQVAVELVN KLRRPGAEIS
STGYPQQSVF KKLYQELEAL GGTILIVLDE VDAIGDRDDL LYELPRARSQ GNLEDAKVGI
IGISNDYKFQ EQLDPRVQDT LCERELQFPP YDALELANIL DSRTDIAIAD DSLAEGVTQH
CAALAARDSG SARQALDLLR LAGELAENQD ADAISTDHVE AARSELERER VEEGMRELTT
HGRLTLLAVV SKAAKADTPS RTRAIYDEYA SLCKSAANTD DPLKQRSVHN HLSDLHMLGI
LSKYENRSGS RGNYYSYELD VPFESAVDAM ADVLMLDAEI EKMEGLASRN GVL
//
