ID CEF1_KLULA Reviewed; 543 AA.
AC Q6CU65;
DT 30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2004, sequence version 1.
DT 24-JAN-2024, entry version 106.
DE RecName: Full=Pre-mRNA-splicing factor CEF1;
GN Name=CEF1; OrderedLocusNames=KLLA0C07304g;
OS Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX NCBI_TaxID=284590;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX PubMed=15229592; DOI=10.1038/nature02579;
RA Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA Weissenbach J., Wincker P., Souciet J.-L.;
RT "Genome evolution in yeasts.";
RL Nature 430:35-44(2004).
CC -!- FUNCTION: Involved in pre-mRNA splicing and cell cycle control.
CC {ECO:0000250}.
CC -!- SUBUNIT: Associated with the spliceosome. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus
CC {ECO:0000255|PROSITE-ProRule:PRU00625}.
CC -!- SIMILARITY: Belongs to the CEF1 family. {ECO:0000305}.
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DR EMBL; CR382123; CAH01375.1; -; Genomic_DNA.
DR RefSeq; XP_452524.1; XM_452524.1.
DR AlphaFoldDB; Q6CU65; -.
DR SMR; Q6CU65; -.
DR STRING; 284590.Q6CU65; -.
DR PaxDb; 284590-Q6CU65; -.
DR GeneID; 2892559; -.
DR KEGG; kla:KLLA0_C07304g; -.
DR eggNOG; KOG0050; Eukaryota.
DR HOGENOM; CLU_009082_2_1_1; -.
DR InParanoid; Q6CU65; -.
DR Proteomes; UP000000598; Chromosome C.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0000974; C:Prp19 complex; IEA:InterPro.
DR GO; GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; IEA:InterPro.
DR CDD; cd00167; SANT; 1.
DR CDD; cd11659; SANT_CDC5_II; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 2.
DR InterPro; IPR047242; CDC5L/Cef1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017930; Myb_dom.
DR InterPro; IPR001005; SANT/Myb.
DR InterPro; IPR047240; SANT_CDC5L_II.
DR PANTHER; PTHR45885; CELL DIVISION CYCLE 5-LIKE PROTEIN; 1.
DR PANTHER; PTHR45885:SF1; CELL DIVISION CYCLE 5-LIKE PROTEIN; 1.
DR Pfam; PF13921; Myb_DNA-bind_6; 1.
DR SMART; SM00717; SANT; 2.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS51294; HTH_MYB; 1.
DR PROSITE; PS50090; MYB_LIKE; 1.
PE 3: Inferred from homology;
KW Coiled coil; Cytoplasm; DNA-binding; mRNA processing; mRNA splicing;
KW Nucleus; Reference proteome; Repeat; Spliceosome.
FT CHAIN 1..543
FT /note="Pre-mRNA-splicing factor CEF1"
FT /id="PRO_0000197101"
FT DOMAIN 1..58
FT /note="HTH myb-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DOMAIN 59..106
FT /note="Myb-like"
FT DNA_BIND 33..56
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT REGION 256..275
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 135..188
FT /evidence="ECO:0000255"
FT COILED 459..541
FT /evidence="ECO:0000255"
SQ SEQUENCE 543 AA; 62296 MW; FE812C43EA03D6A9 CRC64;
MAPVPIYVKG GIWTNLEDQI LKAAVQKYGT HAWSKVASLL QKKNARQCQS RWNEFLNPSL
NFKPFSQQED DKLLDLAKRI PNQWKSIGEM MGRPAQTCID RYNILLAIDK DDLELAATTG
VQIGEINPNN ESLPAKADKD ELLDEEREML AEARARLLNT QGKKATRKIR ERMLEESKRV
AFLQKRRELK QAGVDSKIKA PRKKYSSQMD YNEDIAYEQQ PLPGIYDTSK EDEQTEKLLK
SFEKLVERKG LLDRKSDEKK TIPQKRRQGE QITSSVTKLD SVLTDEYKKP KLELTPATLK
GSKRKINKTT SILHLFESLP SPKNDFEIVL DDLDEEMEST DAFNTESSYV NGKYPLEALI
SSTEHQSENK AMEIMEYIPT VFQIKTELQV PSPIVDPKNE IDRELNRIIS AKENGNPIYN
STEVNNYLEE IINSASTTEV PSTVLHPKLE TSLKTITPAT EHELLGMERK VHELRTALED
SVKSHREAVS QLSQDFEEKL HPTVSGLAYQ YYTDYMKYRN DHKTMQEETQ SLAEQIKLAQ
RSQ
//
