ID CEP76_HUMAN Reviewed; 659 AA.
AC Q8TAP6; B0YJB2; B4DXG5; B4DZW1; Q658N5; Q9H9U7;
DT 15-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 27-MAR-2024, entry version 165.
DE RecName: Full=Centrosomal protein of 76 kDa;
DE Short=Cep76;
GN Name=CEP76; Synonyms=C18orf9;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
RC TISSUE=Teratocarcinoma, Testis, and Thymus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RG NHLBI resequencing and genotyping service (RS&G);
RL Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16177791; DOI=10.1038/nature03983;
RA Nusbaum C., Zody M.C., Borowsky M.L., Kamal M., Kodira C.D., Taylor T.D.,
RA Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X.,
RA Abouelleil A., Allen N.R., Anderson S., Bloom T., Bugalter B., Butler J.,
RA Cook A., DeCaprio D., Engels R., Garber M., Gnirke A., Hafez N., Hall J.L.,
RA Norman C.H., Itoh T., Jaffe D.B., Kuroki Y., Lehoczky J., Lui A.,
RA Macdonald P., Mauceli E., Mikkelsen T.S., Naylor J.W., Nicol R., Nguyen C.,
RA Noguchi H., O'Leary S.B., Piqani B., Smith C.L., Talamas J.A., Topham K.,
RA Totoki Y., Toyoda A., Wain H.M., Young S.K., Zeng Q., Zimmer A.R.,
RA Fujiyama A., Hattori M., Birren B.W., Sakaki Y., Lander E.S.;
RT "DNA sequence and analysis of human chromosome 18.";
RL Nature 437:551-555(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-73.
RC TISSUE=Stomach;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [7]
RP IDENTIFICATION BY MASS SPECTROMETRY, AND SUBCELLULAR LOCATION [LARGE SCALE
RP ANALYSIS].
RC TISSUE=Lymphoblast;
RX PubMed=14654843; DOI=10.1038/nature02166;
RA Andersen J.S., Wilkinson C.J., Mayor T., Mortensen P., Nigg E.A., Mann M.;
RT "Proteomic characterization of the human centrosome by protein correlation
RT profiling.";
RL Nature 426:570-574(2003).
RN [8]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18691976; DOI=10.1016/j.molcel.2008.07.007;
RA Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,
RA Greff Z., Keri G., Stemmann O., Mann M.;
RT "Kinase-selective enrichment enables quantitative phosphoproteomics of the
RT kinome across the cell cycle.";
RL Mol. Cell 31:438-448(2008).
RN [9]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-83, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [10]
RP FUNCTION, SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE, AND INTERACTION WITH
RP CCP110 AND CEP97.
RX PubMed=19460342; DOI=10.1016/j.devcel.2009.03.004;
RA Tsang W.Y., Spektor A., Vijayakumar S., Bista B.R., Li J., Sanchez I.,
RA Duensing S., Dynlacht B.D.;
RT "Cep76, a centrosomal protein that specifically restrains centriole
RT reduplication.";
RL Dev. Cell 16:649-660(2009).
RN [11]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-83, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Leukemic T-cell;
RX PubMed=19690332; DOI=10.1126/scisignal.2000007;
RA Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,
RA Rodionov V., Han D.K.;
RT "Quantitative phosphoproteomic analysis of T cell receptor signaling
RT reveals system-wide modulation of protein-protein interactions.";
RL Sci. Signal. 2:RA46-RA46(2009).
CC -!- FUNCTION: Centrosomal protein involved in regulation of centriole
CC duplication. Required to limit centriole duplication to once per cell
CC cycle by preventing centriole reduplication.
CC {ECO:0000269|PubMed:19460342}.
CC -!- SUBUNIT: Interacts with CCP110 and CEP97.
CC {ECO:0000269|PubMed:19460342}.
CC -!- INTERACTION:
CC Q8TAP6; O43687-2: AKAP7; NbExp=6; IntAct=EBI-742887, EBI-10185182;
CC Q8TAP6; P31749: AKT1; NbExp=3; IntAct=EBI-742887, EBI-296087;
CC Q8TAP6; A1A5B0: ANKRD36; NbExp=3; IntAct=EBI-742887, EBI-14100900;
CC Q8TAP6; Q9UBL3: ASH2L; NbExp=3; IntAct=EBI-742887, EBI-540797;
CC Q8TAP6; A0A0S2Z5G4: BANP; NbExp=3; IntAct=EBI-742887, EBI-16429704;
CC Q8TAP6; B4DE54: BANP; NbExp=3; IntAct=EBI-742887, EBI-16429313;
CC Q8TAP6; Q8N9N5: BANP; NbExp=3; IntAct=EBI-742887, EBI-744695;
CC Q8TAP6; Q8N9N5-2: BANP; NbExp=3; IntAct=EBI-742887, EBI-11524452;
CC Q8TAP6; Q8N9N5-7: BANP; NbExp=3; IntAct=EBI-742887, EBI-16429296;
CC Q8TAP6; Q6P5X5: C22orf39; NbExp=6; IntAct=EBI-742887, EBI-7317823;
CC Q8TAP6; Q9NP86: CABP5; NbExp=8; IntAct=EBI-742887, EBI-10311131;
CC Q8TAP6; P54284: CACNB3; NbExp=3; IntAct=EBI-742887, EBI-1184651;
CC Q8TAP6; A0A0S2Z3E6: CAPN3; NbExp=3; IntAct=EBI-742887, EBI-16430532;
CC Q8TAP6; Q969G5: CAVIN3; NbExp=3; IntAct=EBI-742887, EBI-3893101;
CC Q8TAP6; Q53HC0: CCDC92; NbExp=3; IntAct=EBI-742887, EBI-719994;
CC Q8TAP6; Q07002: CDK18; NbExp=3; IntAct=EBI-742887, EBI-746238;
CC Q8TAP6; Q92674: CENPI; NbExp=3; IntAct=EBI-742887, EBI-11085153;
CC Q8TAP6; Q86X95: CIR1; NbExp=3; IntAct=EBI-742887, EBI-627102;
CC Q8TAP6; P53673: CRYBA4; NbExp=9; IntAct=EBI-742887, EBI-7519711;
CC Q8TAP6; Q9HCP0: CSNK1G1; NbExp=3; IntAct=EBI-742887, EBI-1383814;
CC Q8TAP6; Q9NTM9: CUTC; NbExp=3; IntAct=EBI-742887, EBI-714918;
CC Q8TAP6; Q2TBE0: CWF19L2; NbExp=3; IntAct=EBI-742887, EBI-5453285;
CC Q8TAP6; P26196: DDX6; NbExp=3; IntAct=EBI-742887, EBI-351257;
CC Q8TAP6; O75398: DEAF1; NbExp=3; IntAct=EBI-742887, EBI-718185;
CC Q8TAP6; Q08495: DMTN; NbExp=3; IntAct=EBI-742887, EBI-715275;
CC Q8TAP6; Q92997: DVL3; NbExp=3; IntAct=EBI-742887, EBI-739789;
CC Q8TAP6; Q8IYY4: DZIP1L; NbExp=5; IntAct=EBI-742887, EBI-10264440;
CC Q8TAP6; Q96JC9: EAF1; NbExp=3; IntAct=EBI-742887, EBI-769261;
CC Q8TAP6; Q8N9N8: EIF1AD; NbExp=3; IntAct=EBI-742887, EBI-750700;
CC Q8TAP6; P19447: ERCC3; NbExp=3; IntAct=EBI-742887, EBI-1183307;
CC Q8TAP6; Q86YD7: FAM90A1; NbExp=6; IntAct=EBI-742887, EBI-6658203;
CC Q8TAP6; Q0VDC6: FKBP1A; NbExp=3; IntAct=EBI-742887, EBI-10226858;
CC Q8TAP6; Q9NXN4: GDAP2; NbExp=3; IntAct=EBI-742887, EBI-10316460;
CC Q8TAP6; Q9H8Y8: GORASP2; NbExp=3; IntAct=EBI-742887, EBI-739467;
CC Q8TAP6; Q03933: HSF2; NbExp=3; IntAct=EBI-742887, EBI-2556750;
CC Q8TAP6; Q9UBY9: HSPB7; NbExp=6; IntAct=EBI-742887, EBI-739361;
CC Q8TAP6; A1L0T0: ILVBL; NbExp=3; IntAct=EBI-742887, EBI-720553;
CC Q8TAP6; Q8NA54: IQUB; NbExp=3; IntAct=EBI-742887, EBI-10220600;
CC Q8TAP6; Q92993: KAT5; NbExp=3; IntAct=EBI-742887, EBI-399080;
CC Q8TAP6; O60341: KDM1A; NbExp=3; IntAct=EBI-742887, EBI-710124;
CC Q8TAP6; Q6B0I6: KDM4D; NbExp=3; IntAct=EBI-742887, EBI-4311651;
CC Q8TAP6; Q9BVV6: KIAA0586; NbExp=2; IntAct=EBI-742887, EBI-11286926;
CC Q8TAP6; Q96AT1: KIAA1143; NbExp=7; IntAct=EBI-742887, EBI-2548425;
CC Q8TAP6; Q8TBB5: KLHDC4; NbExp=3; IntAct=EBI-742887, EBI-8472352;
CC Q8TAP6; Q969R5: L3MBTL2; NbExp=3; IntAct=EBI-742887, EBI-739909;
CC Q8TAP6; Q6PJG3: LATS1; NbExp=3; IntAct=EBI-742887, EBI-10253976;
CC Q8TAP6; Q8TAP4-4: LMO3; NbExp=3; IntAct=EBI-742887, EBI-11742507;
CC Q8TAP6; Q8TBB1: LNX1; NbExp=3; IntAct=EBI-742887, EBI-739832;
CC Q8TAP6; O95983: MBD3; NbExp=3; IntAct=EBI-742887, EBI-1783068;
CC Q8TAP6; O95983-2: MBD3; NbExp=3; IntAct=EBI-742887, EBI-11978579;
CC Q8TAP6; P55081: MFAP1; NbExp=3; IntAct=EBI-742887, EBI-1048159;
CC Q8TAP6; Q8IVT2: MISP; NbExp=3; IntAct=EBI-742887, EBI-2555085;
CC Q8TAP6; Q9NP98: MYOZ1; NbExp=3; IntAct=EBI-742887, EBI-744402;
CC Q8TAP6; Q9HC98-4: NEK6; NbExp=3; IntAct=EBI-742887, EBI-11750983;
CC Q8TAP6; Q13952-2: NFYC; NbExp=3; IntAct=EBI-742887, EBI-11956831;
CC Q8TAP6; Q8NBF2: NHLRC2; NbExp=3; IntAct=EBI-742887, EBI-10269163;
CC Q8TAP6; Q8NBF2-2: NHLRC2; NbExp=3; IntAct=EBI-742887, EBI-10697320;
CC Q8TAP6; A0A0S2Z4M0: NME5; NbExp=4; IntAct=EBI-742887, EBI-16430544;
CC Q8TAP6; P07237: P4HB; NbExp=3; IntAct=EBI-742887, EBI-395883;
CC Q8TAP6; Q9BYG5: PARD6B; NbExp=6; IntAct=EBI-742887, EBI-295391;
CC Q8TAP6; Q9HBE1-4: PATZ1; NbExp=3; IntAct=EBI-742887, EBI-11022007;
CC Q8TAP6; P09619: PDGFRB; NbExp=3; IntAct=EBI-742887, EBI-641237;
CC Q8TAP6; Q9NUG6: PDRG1; NbExp=3; IntAct=EBI-742887, EBI-307050;
CC Q8TAP6; Q17RL8: PDZD4; NbExp=3; IntAct=EBI-742887, EBI-10239064;
CC Q8TAP6; Q13526: PIN1; NbExp=6; IntAct=EBI-742887, EBI-714158;
CC Q8TAP6; Q13835-2: PKP1; NbExp=3; IntAct=EBI-742887, EBI-9087684;
CC Q8TAP6; O60733: PLA2G6; NbExp=3; IntAct=EBI-742887, EBI-12089905;
CC Q8TAP6; Q9NQ66: PLCB1; NbExp=3; IntAct=EBI-742887, EBI-3396023;
CC Q8TAP6; Q96HA1: POM121; NbExp=3; IntAct=EBI-742887, EBI-739990;
CC Q8TAP6; Q96HA1-2: POM121; NbExp=3; IntAct=EBI-742887, EBI-11956563;
CC Q8TAP6; P62937-2: PPIA; NbExp=3; IntAct=EBI-742887, EBI-25884072;
CC Q8TAP6; Q96JH8: RADIL; NbExp=3; IntAct=EBI-742887, EBI-744267;
CC Q8TAP6; Q5JS13-3: RALGPS1; NbExp=3; IntAct=EBI-742887, EBI-12217281;
CC Q8TAP6; Q96IZ5: RBM41; NbExp=3; IntAct=EBI-742887, EBI-740773;
CC Q8TAP6; P57055: RIPPLY3; NbExp=3; IntAct=EBI-742887, EBI-12092053;
CC Q8TAP6; Q8TEB7: RNF128; NbExp=6; IntAct=EBI-742887, EBI-2341619;
CC Q8TAP6; P32969: RPL9P9; NbExp=7; IntAct=EBI-742887, EBI-358122;
CC Q8TAP6; Q9Y467: SALL2; NbExp=4; IntAct=EBI-742887, EBI-746180;
CC Q8TAP6; Q9BWG6: SCNM1; NbExp=3; IntAct=EBI-742887, EBI-748391;
CC Q8TAP6; Q15047-2: SETDB1; NbExp=3; IntAct=EBI-742887, EBI-9090795;
CC Q8TAP6; Q9H788: SH2D4A; NbExp=3; IntAct=EBI-742887, EBI-747035;
CC Q8TAP6; Q9H0W8: SMG9; NbExp=3; IntAct=EBI-742887, EBI-2872322;
CC Q8TAP6; Q9NZD8: SPG21; NbExp=3; IntAct=EBI-742887, EBI-742688;
CC Q8TAP6; P51687: SUOX; NbExp=3; IntAct=EBI-742887, EBI-3921347;
CC Q8TAP6; Q15560: TCEA2; NbExp=3; IntAct=EBI-742887, EBI-710310;
CC Q8TAP6; Q8N8B7-2: TCEANC; NbExp=3; IntAct=EBI-742887, EBI-11955057;
CC Q8TAP6; Q9Y242: TCF19; NbExp=3; IntAct=EBI-742887, EBI-7413767;
CC Q8TAP6; Q7Z6R9: TFAP2D; NbExp=3; IntAct=EBI-742887, EBI-11952651;
CC Q8TAP6; P10827: THRA; NbExp=4; IntAct=EBI-742887, EBI-286285;
CC Q8TAP6; Q14106: TOB2; NbExp=3; IntAct=EBI-742887, EBI-2562000;
CC Q8TAP6; Q9Y5U2: TSSC4; NbExp=3; IntAct=EBI-742887, EBI-717229;
CC Q8TAP6; A0A0B4J1Y2: TTC21A; NbExp=6; IntAct=EBI-742887, EBI-10220701;
CC Q8TAP6; Q6ZVT0-3: TTLL10; NbExp=3; IntAct=EBI-742887, EBI-11979997;
CC Q8TAP6; Q9NNX1: TUFT1; NbExp=3; IntAct=EBI-742887, EBI-2557363;
CC Q8TAP6; O14530: TXNDC9; NbExp=3; IntAct=EBI-742887, EBI-707554;
CC Q8TAP6; Q14119: VEZF1; NbExp=3; IntAct=EBI-742887, EBI-11980193;
CC Q8TAP6; Q8IZQ1-2: WDFY3; NbExp=3; IntAct=EBI-742887, EBI-10264625;
CC Q8TAP6; P61981: YWHAG; NbExp=3; IntAct=EBI-742887, EBI-359832;
CC Q8TAP6; P25490: YY1; NbExp=3; IntAct=EBI-742887, EBI-765538;
CC Q8TAP6; O43167: ZBTB24; NbExp=6; IntAct=EBI-742887, EBI-744471;
CC Q8TAP6; Q9P1Z0: ZBTB4; NbExp=3; IntAct=EBI-742887, EBI-2564133;
CC Q8TAP6; Q96NC0: ZMAT2; NbExp=3; IntAct=EBI-742887, EBI-2682299;
CC Q8TAP6; O15231: ZNF185; NbExp=3; IntAct=EBI-742887, EBI-6874731;
CC Q8TAP6; Q96CK0: ZNF653; NbExp=3; IntAct=EBI-742887, EBI-12217757;
CC Q8TAP6; P36508: ZNF76; NbExp=3; IntAct=EBI-742887, EBI-7254550;
CC Q8TAP6; Q03923-3: ZNF85; NbExp=3; IntAct=EBI-742887, EBI-10223330;
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC center, centrosome {ECO:0000269|PubMed:14654843}. Cytoplasm,
CC cytoskeleton, microtubule organizing center, centrosome, centriole.
CC Note=Does not localize along the ciliary axoneme.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q8TAP6-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8TAP6-2; Sequence=VSP_037611;
CC Name=3;
CC IsoId=Q8TAP6-3; Sequence=VSP_037610, VSP_037612, VSP_037613;
CC -!- DEVELOPMENTAL STAGE: Expressed at low level in G1 and is induced in S
CC and G2 phase, during which point centrioles have already commenced
CC duplication (at protein level). {ECO:0000269|PubMed:19460342}.
CC -!- SIMILARITY: Belongs to the CEP76 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAG64223.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};
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DR EMBL; AK022604; BAB14123.1; -; mRNA.
DR EMBL; AK301964; BAG63377.1; -; mRNA.
DR EMBL; AK303117; BAG64223.1; ALT_SEQ; mRNA.
DR EMBL; EF445040; ACA06091.1; -; Genomic_DNA.
DR EMBL; AP005482; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471113; EAX01543.1; -; Genomic_DNA.
DR EMBL; BC026307; AAH26307.1; -; mRNA.
DR EMBL; AL833727; CAH56252.1; -; mRNA.
DR CCDS; CCDS11861.1; -. [Q8TAP6-1]
DR CCDS; CCDS62390.1; -. [Q8TAP6-2]
DR RefSeq; NP_001258918.1; NM_001271989.1. [Q8TAP6-2]
DR RefSeq; NP_079175.2; NM_024899.3. [Q8TAP6-1]
DR AlphaFoldDB; Q8TAP6; -.
DR SMR; Q8TAP6; -.
DR BioGRID; 123028; 236.
DR IntAct; Q8TAP6; 130.
DR MINT; Q8TAP6; -.
DR STRING; 9606.ENSP00000262127; -.
DR iPTMnet; Q8TAP6; -.
DR PhosphoSitePlus; Q8TAP6; -.
DR SwissPalm; Q8TAP6; -.
DR BioMuta; CEP76; -.
DR DMDM; 59797956; -.
DR EPD; Q8TAP6; -.
DR jPOST; Q8TAP6; -.
DR MassIVE; Q8TAP6; -.
DR MaxQB; Q8TAP6; -.
DR PaxDb; 9606-ENSP00000262127; -.
DR PeptideAtlas; Q8TAP6; -.
DR ProteomicsDB; 73901; -. [Q8TAP6-1]
DR ProteomicsDB; 73902; -. [Q8TAP6-2]
DR ProteomicsDB; 73903; -. [Q8TAP6-3]
DR Pumba; Q8TAP6; -.
DR Antibodypedia; 21948; 175 antibodies from 23 providers.
DR DNASU; 79959; -.
DR Ensembl; ENST00000262127.7; ENSP00000262127.2; ENSG00000101624.11. [Q8TAP6-1]
DR Ensembl; ENST00000423709.6; ENSP00000403074.1; ENSG00000101624.11. [Q8TAP6-2]
DR GeneID; 79959; -.
DR KEGG; hsa:79959; -.
DR MANE-Select; ENST00000262127.7; ENSP00000262127.2; NM_024899.4; NP_079175.2.
DR UCSC; uc002kri.5; human. [Q8TAP6-1]
DR AGR; HGNC:25727; -.
DR CTD; 79959; -.
DR DisGeNET; 79959; -.
DR GeneCards; CEP76; -.
DR HGNC; HGNC:25727; CEP76.
DR HPA; ENSG00000101624; Low tissue specificity.
DR neXtProt; NX_Q8TAP6; -.
DR OpenTargets; ENSG00000101624; -.
DR PharmGKB; PA134916911; -.
DR VEuPathDB; HostDB:ENSG00000101624; -.
DR eggNOG; ENOG502QQEI; Eukaryota.
DR GeneTree; ENSGT00390000000781; -.
DR HOGENOM; CLU_027144_0_0_1; -.
DR InParanoid; Q8TAP6; -.
DR OMA; RRWWSEY; -.
DR OrthoDB; 315381at2759; -.
DR PhylomeDB; Q8TAP6; -.
DR TreeFam; TF329324; -.
DR PathwayCommons; Q8TAP6; -.
DR Reactome; R-HSA-2565942; Regulation of PLK1 Activity at G2/M Transition.
DR Reactome; R-HSA-380259; Loss of Nlp from mitotic centrosomes.
DR Reactome; R-HSA-380270; Recruitment of mitotic centrosome proteins and complexes.
DR Reactome; R-HSA-380284; Loss of proteins required for interphase microtubule organization from the centrosome.
DR Reactome; R-HSA-380320; Recruitment of NuMA to mitotic centrosomes.
DR Reactome; R-HSA-5620912; Anchoring of the basal body to the plasma membrane.
DR Reactome; R-HSA-8854518; AURKA Activation by TPX2.
DR SignaLink; Q8TAP6; -.
DR SIGNOR; Q8TAP6; -.
DR BioGRID-ORCS; 79959; 14 hits in 1157 CRISPR screens.
DR ChiTaRS; CEP76; human.
DR GeneWiki; CEP76; -.
DR GenomeRNAi; 79959; -.
DR Pharos; Q8TAP6; Tdark.
DR PRO; PR:Q8TAP6; -.
DR Proteomes; UP000005640; Chromosome 18.
DR RNAct; Q8TAP6; Protein.
DR Bgee; ENSG00000101624; Expressed in secondary oocyte and 165 other cell types or tissues.
DR ExpressionAtlas; Q8TAP6; baseline and differential.
DR Genevisible; Q8TAP6; HS.
DR GO; GO:0005814; C:centriole; IDA:UniProtKB.
DR GO; GO:0005813; C:centrosome; IDA:UniProtKB.
DR GO; GO:0005829; C:cytosol; TAS:Reactome.
DR GO; GO:0032991; C:protein-containing complex; IDA:MGI.
DR GO; GO:0046599; P:regulation of centriole replication; IMP:UniProtKB.
DR Gene3D; 3.10.620.30; -; 1.
DR InterPro; IPR028926; CEP76-C2.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR PANTHER; PTHR46436; CENTROSOMAL PROTEIN OF 76 KDA; 1.
DR PANTHER; PTHR46436:SF1; CENTROSOMAL PROTEIN OF 76 KDA; 1.
DR Pfam; PF15627; CEP76-C2; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cytoplasm; Cytoskeleton; Phosphoprotein;
KW Reference proteome.
FT CHAIN 1..659
FT /note="Centrosomal protein of 76 kDa"
FT /id="PRO_0000089501"
FT MOD_RES 75
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q0VEJ0"
FT MOD_RES 83
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648,
FT ECO:0007744|PubMed:19690332"
FT VAR_SEQ 1..178
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_037610"
FT VAR_SEQ 99..174
FT /note="TNIDPTRRYLYLQVLGGKAFLEHLQEPEPLPGQVCSTFTLCLHYRNQRFRSK
FT PVPCACEPDFHDGFLLEVHRESLG -> S (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_037611"
FT VAR_SEQ 431..445
FT /note="YIHKPTNPDEPPVAE -> LCFQPSDVPGKLSTL (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_037612"
FT VAR_SEQ 446..659
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_037613"
FT CONFLICT 314
FT /note="N -> S (in Ref. 1; BAB14123)"
FT /evidence="ECO:0000305"
FT CONFLICT 606
FT /note="R -> G (in Ref. 1; BAB14123)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 659 AA; 74413 MW; 66EB85DCDCBEE518 CRC64;
MSLPPEKASE LKQLIHQQLS KMDVHGRIRE ILAETIREEL APDQQHLSTE DLIKALRRRG
IIDDVMKELN FVTDSVEQEL PSSPKQPICF DRQSTLKKTN IDPTRRYLYL QVLGGKAFLE
HLQEPEPLPG QVCSTFTLCL HYRNQRFRSK PVPCACEPDF HDGFLLEVHR ESLGDGTRMA
DSTTMLSISD PIHMVLIKTD IFGETTLVAS YFLEWRSVLG SENGVTSLTV ELMGVGTESK
VSVGILNIKL EMYPPLNQTL SQEVVNTQLA LERQKTAEKE RLFLVYAKQW WREYLQIRPS
HNSRLVKIFA QDENGINRPV CSYVKPLRAG RLLDTPRQAA RFVNVLGYER APVIGGGGKQ
EQWCTLLAFL CRNKGDCEDH ANLLCSLLLG YGLEAFVCVG TKAKGVPHAW VMTCGTDGAI
TFWESLTGHR YIHKPTNPDE PPVAEQPKPL YPYRTIGCVF NHQMFLGNCQ PSDAVETCVF
DLNDESKWKP MSEEAIKSVC APGATTSLPP FPPLCASTID ASVTSNEIEM QLRLLVSEHR
KDLGLTTVWE DQLSYLLSPA LASYEFERTT SISAGNEEFQ DAIRRAVPDG HTFKGFPIHF
VYRNARRAFA TCLRSPFCEE IICCRGDQVR LAVRVRVFTY PESACAVWIM FACKYRSVL
//
