ID CHM1B_DANRE Reviewed; 199 AA.
AC Q7ZVB1;
DT 30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 27-MAR-2024, entry version 109.
DE RecName: Full=Charged multivesicular body protein 1b;
DE AltName: Full=Chromatin-modifying protein 1b;
DE Short=CHMP1b;
GN Name=chmp1b; ORFNames=zgc:56134;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Kidney marrow;
RX PubMed=15520368; DOI=10.1073/pnas.0407241101;
RA Song H.-D., Sun X.-J., Deng M., Zhang G.-W., Zhou Y., Wu X.-Y., Sheng Y.,
RA Chen Y., Ruan Z., Jiang C.-L., Fan H.-Y., Zon L.I., Kanki J.P., Liu T.X.,
RA Look A.T., Chen Z.;
RT "Hematopoietic gene expression profile in zebrafish kidney marrow.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:16240-16245(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Probable peripherally associated component of the endosomal
CC sorting required for transport complex III (ESCRT-III) which is
CC involved in multivesicular bodies (MVBs) formation and sorting of
CC endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles
CC (ILVs) that are generated by invagination and scission from the
CC limiting membrane of the endosome and mostly are delivered to lysosomes
CC enabling degradation of membrane proteins, such as stimulated growth
CC factor receptors, lysosomal enzymes and lipids.
CC -!- SUBUNIT: Probable peripherally associated component of the endosomal
CC sorting required for transport complex III (ESCRT-III).
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250}. Endosome
CC {ECO:0000250}. Late endosome membrane {ECO:0000250}; Peripheral
CC membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the SNF7 family. {ECO:0000305}.
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DR EMBL; AY398326; AAQ97759.1; -; mRNA.
DR EMBL; BC045934; AAH45934.1; -; mRNA.
DR EMBL; BC065462; AAH65462.1; -; mRNA.
DR EMBL; BC067569; AAH67569.1; -; mRNA.
DR RefSeq; NP_956308.1; NM_200014.1.
DR RefSeq; XP_009299564.1; XM_009301289.2.
DR AlphaFoldDB; Q7ZVB1; -.
DR SMR; Q7ZVB1; -.
DR STRING; 7955.ENSDARP00000134015; -.
DR GeneID; 336426; -.
DR KEGG; dre:336426; -.
DR AGR; ZFIN:ZDB-GENE-030131-8370; -.
DR CTD; 57132; -.
DR ZFIN; ZDB-GENE-030131-8370; chmp1b.
DR HOGENOM; CLU_080826_0_1_1; -.
DR InParanoid; Q7ZVB1; -.
DR OMA; VMDRFET; -.
DR OrthoDB; 260657at2759; -.
DR PhylomeDB; Q7ZVB1; -.
DR PRO; PR:Q7ZVB1; -.
DR Proteomes; UP000000437; Alternate scaffold 5.
DR Proteomes; UP000000437; Chromosome 5.
DR Bgee; ENSDARG00000099624; Expressed in pharyngeal gill and 28 other cell types or tissues.
DR ExpressionAtlas; Q7ZVB1; baseline and differential.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR GO; GO:0000815; C:ESCRT III complex; IBA:GO_Central.
DR GO; GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005771; C:multivesicular body; IBA:GO_Central.
DR GO; GO:0032509; P:endosome transport via multivesicular body sorting pathway; IBA:GO_Central.
DR GO; GO:0045324; P:late endosome to vacuole transport; IBA:GO_Central.
DR GO; GO:0015031; P:protein transport; IBA:GO_Central.
DR Gene3D; 6.10.140.1230; -; 1.
DR InterPro; IPR005024; Snf7_fam.
DR PANTHER; PTHR10476; CHARGED MULTIVESICULAR BODY PROTEIN; 1.
DR PANTHER; PTHR10476:SF2; CHARGED MULTIVESICULAR BODY PROTEIN 1B; 1.
DR Pfam; PF03357; Snf7; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Cytoplasm; Endosome; Membrane; Protein transport;
KW Reference proteome; Transport.
FT CHAIN 1..199
FT /note="Charged multivesicular body protein 1b"
FT /id="PRO_0000211458"
FT REGION 167..199
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 10..30
FT /evidence="ECO:0000255"
FT COILED 178..199
FT /evidence="ECO:0000255"
FT MOTIF 186..196
FT /note="MIT-interacting motif"
FT COMPBIAS 168..186
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 199 AA; 22063 MW; 880EE28120DC1862 CRC64;
MSSMEKHLFN LKFAAKELQR NSKKCDKEEK AEKVKVKKAI QKGNMEVARI HAENAIRQKN
QSVNFLRMSA RVDAVAARVQ TAVTMNQVTK SMAGVVKGMD ATLKSMNLEK ISGLMEKFER
QFETLDVQTA QMEDSMSSTT TLTTPQGQVD TLMMEMADEA GLDLNMELPQ GQTGSVGTSV
ASAEQDELSQ RLAKLRDQV
//
