ID CLD14_MOUSE Reviewed; 239 AA.
AC Q9Z0S3; Q9D284;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 14-AUG-2001, sequence version 2.
DT 24-JAN-2024, entry version 151.
DE RecName: Full=Claudin-14;
GN Name=Cldn14;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Liver;
RA Morita K., Furuse M., Tsukita S.;
RL Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC TISSUE=Brain;
RX PubMed=11163249; DOI=10.1016/s0092-8674(01)00200-8;
RA Wilcox E.R., Burton Q.L., Naz S., Riazuddin S., Smith T.N., Ploplis B.,
RA Belyantseva I., Ben-Yosef T., Liburd N.A., Morell R.J., Kachar B., Wu D.K.,
RA Griffith A.J., Riazuddin S., Friedman T.B.;
RT "Mutations in the gene encoding tight junction claudin-14 cause autosomal
RT recessive deafness DFNB29.";
RL Cell 104:165-172(2001).
RN [3]
RP SEQUENCE REVISION TO 115; 129; 166 AND 187.
RA Wilcox E.R., Burton Q.L., Naz S., Riazuddin S., Smith T.N., Ploplis B.,
RA Belyantseva I., Ben-Yosef T., Liburd N.A., Morell R.J., Kachar B., Wu D.K.,
RA Griffith A.J., Riazuddin S., Friedman T.B.;
RL Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Colon;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
CC -!- FUNCTION: Plays a major role in tight junction-specific obliteration of
CC the intercellular space, through calcium-independent cell-adhesion
CC activity. {ECO:0000250}.
CC -!- INTERACTION:
CC Q9Z0S3; Q9Y5I7: CLDN16; Xeno; NbExp=3; IntAct=EBI-7774956, EBI-7774981;
CC -!- SUBCELLULAR LOCATION: Cell junction, tight junction. Cell membrane;
CC Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Expressed in all sensory epithelia of the inner ear
CC vestibular organs, as well as in liver and kidney.
CC {ECO:0000269|PubMed:11163249}.
CC -!- DEVELOPMENTAL STAGE: At postnatal day 4, expression is apically located
CC in the inner and outer hair cell region of the entire organ of Corti.
CC By postnatal day 8, expression is highest in the supporting cells of
CC the organ of Corti.
CC -!- SIMILARITY: Belongs to the claudin family. {ECO:0000305}.
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DR EMBL; AF124429; AAD17323.1; -; mRNA.
DR EMBL; AF314089; AAG60051.2; -; mRNA.
DR EMBL; AK020255; BAB32041.1; -; mRNA.
DR CCDS; CCDS28345.1; -.
DR RefSeq; NP_001159397.1; NM_001165925.1.
DR RefSeq; NP_001159398.1; NM_001165926.1.
DR RefSeq; NP_062373.3; NM_019500.4.
DR RefSeq; XP_006523130.1; XM_006523067.3.
DR AlphaFoldDB; Q9Z0S3; -.
DR SMR; Q9Z0S3; -.
DR IntAct; Q9Z0S3; 2.
DR MINT; Q9Z0S3; -.
DR STRING; 10090.ENSMUSP00000062045; -.
DR iPTMnet; Q9Z0S3; -.
DR PhosphoSitePlus; Q9Z0S3; -.
DR PaxDb; 10090-ENSMUSP00000062045; -.
DR ProteomicsDB; 283577; -.
DR Antibodypedia; 23104; 274 antibodies from 32 providers.
DR DNASU; 56173; -.
DR Ensembl; ENSMUST00000050962.5; ENSMUSP00000062045.5; ENSMUSG00000047109.14.
DR Ensembl; ENSMUST00000169391.8; ENSMUSP00000126455.2; ENSMUSG00000047109.14.
DR Ensembl; ENSMUST00000177648.8; ENSMUSP00000136156.2; ENSMUSG00000047109.14.
DR GeneID; 56173; -.
DR KEGG; mmu:56173; -.
DR UCSC; uc008aad.2; mouse.
DR AGR; MGI:1860425; -.
DR CTD; 23562; -.
DR MGI; MGI:1860425; Cldn14.
DR VEuPathDB; HostDB:ENSMUSG00000047109; -.
DR eggNOG; ENOG502QR8Z; Eukaryota.
DR GeneTree; ENSGT00940000161312; -.
DR HOGENOM; CLU_076370_1_1_1; -.
DR InParanoid; Q9Z0S3; -.
DR OMA; PTAYKDN; -.
DR OrthoDB; 4040914at2759; -.
DR PhylomeDB; Q9Z0S3; -.
DR TreeFam; TF331936; -.
DR BioGRID-ORCS; 56173; 1 hit in 79 CRISPR screens.
DR PRO; PR:Q9Z0S3; -.
DR Proteomes; UP000000589; Chromosome 16.
DR RNAct; Q9Z0S3; Protein.
DR Bgee; ENSMUSG00000047109; Expressed in lumbar subsegment of spinal cord and 101 other cell types or tissues.
DR ExpressionAtlas; Q9Z0S3; baseline and differential.
DR Genevisible; Q9Z0S3; MM.
DR GO; GO:0005923; C:bicellular tight junction; IDA:MGI.
DR GO; GO:0005886; C:plasma membrane; IDA:MGI.
DR GO; GO:0042802; F:identical protein binding; ISS:UniProtKB.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0070830; P:bicellular tight junction assembly; IBA:GO_Central.
DR GO; GO:0016338; P:calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules; ISS:UniProtKB.
DR GO; GO:0007155; P:cell adhesion; IBA:GO_Central.
DR Gene3D; 1.20.140.150; -; 1.
DR InterPro; IPR006187; Claudin.
DR InterPro; IPR017974; Claudin_CS.
DR InterPro; IPR004031; PMP22/EMP/MP20/Claudin.
DR PANTHER; PTHR12002; CLAUDIN; 1.
DR PANTHER; PTHR12002:SF99; CLAUDIN-14; 1.
DR Pfam; PF00822; PMP22_Claudin; 1.
DR PRINTS; PR01077; CLAUDIN.
DR PRINTS; PR01385; CLAUDIN14.
DR PROSITE; PS01346; CLAUDIN; 1.
PE 1: Evidence at protein level;
KW Cell junction; Cell membrane; Membrane; Reference proteome; Tight junction;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..239
FT /note="Claudin-14"
FT /id="PRO_0000144770"
FT TOPO_DOM 1..7
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 8..28
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 29..81
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 82..102
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 103..115
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 116..136
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 137..162
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 163..183
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 184..239
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CONFLICT 115
FT /note="T -> N (in Ref. 1; AAD17323)"
FT /evidence="ECO:0000305"
FT CONFLICT 119
FT /note="V -> M (in Ref. 4; BAB32041)"
FT /evidence="ECO:0000305"
FT CONFLICT 129
FT /note="G -> A (in Ref. 1; AAD17323)"
FT /evidence="ECO:0000305"
FT CONFLICT 166
FT /note="L -> M (in Ref. 1; AAD17323)"
FT /evidence="ECO:0000305"
FT CONFLICT 187
FT /note="D -> E (in Ref. 1; AAD17323)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 239 AA; 25614 MW; 24DE6AEADA56BB61 CRC64;
MASTAVQLLG FLLSFLGMVG TLITTILPHW RRTAHVGTNI LTAVSYLKGL WMECVWHSTG
IYQCQIYRSL LALPRDLQAA RALMVISCLL SGMACACAVV GMKCTRCAKG TPAKTTFAVL
GGALFLLAGL LCMVAVSWTT NDVVQNFYNP LLPSGMKFEI GQALYLGFIS SSLSLIGGTL
LCLSCQDEAP YRPYPPQSRA GATTTATAPA YRPPAAYKDN RAPSVTSAAH SGYRLNDYV
//
