ID CLP1H_CAEEL Reviewed; 937 AA.
AC P34531; P34532; P34533; Q65ZC5;
DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2004, sequence version 4.
DT 27-MAR-2024, entry version 134.
DE RecName: Full=CAP-Gly domain-containing linker protein 1 homolog {ECO:0000312|WormBase:M01A8.2a};
GN Name=clip-1 {ECO:0000312|WormBase:M01A8.2a};
GN ORFNames=M01A8.2 {ECO:0000312|WormBase:M01A8.2a};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=7906398; DOI=10.1038/368032a0;
RA Wilson R., Ainscough R., Anderson K., Baynes C., Berks M., Bonfield J.,
RA Burton J., Connell M., Copsey T., Cooper J., Coulson A., Craxton M.,
RA Dear S., Du Z., Durbin R., Favello A., Fraser A., Fulton L., Gardner A.,
RA Green P., Hawkins T., Hillier L., Jier M., Johnston L., Jones M.,
RA Kershaw J., Kirsten J., Laisster N., Latreille P., Lightning J., Lloyd C.,
RA Mortimore B., O'Callaghan M., Parsons J., Percy C., Rifken L., Roopra A.,
RA Saunders D., Shownkeen R., Sims M., Smaldon N., Smith A., Smith M.,
RA Sonnhammer E., Staden R., Sulston J., Thierry-Mieg J., Thomas K.,
RA Vaudin M., Vaughan K., Waterston R., Watson A., Weinstock L.,
RA Wilkinson-Sproat J., Wohldman P.;
RT "2.2 Mb of contiguous nucleotide sequence from chromosome III of C.
RT elegans.";
RL Nature 368:32-38(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE SPLICING.
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=a;
CC IsoId=P34531-1; Sequence=Displayed;
CC Name=b;
CC IsoId=P34531-2; Sequence=VSP_016341;
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; Z27081; CAA81607.2; -; Genomic_DNA.
DR EMBL; Z27081; CAH19085.1; -; Genomic_DNA.
DR PIR; G88551; G88551.
DR PIR; S40998; S40998.
DR PIR; S40999; S40999.
DR RefSeq; NP_001022682.1; NM_001027511.3. [P34531-1]
DR RefSeq; NP_001022683.1; NM_001027512.5. [P34531-2]
DR AlphaFoldDB; P34531; -.
DR SMR; P34531; -.
DR BioGRID; 41505; 1.
DR STRING; 6239.M01A8.2a.1; -.
DR iPTMnet; P34531; -.
DR EPD; P34531; -.
DR PaxDb; 6239-M01A8-2a; -.
DR PeptideAtlas; P34531; -.
DR EnsemblMetazoa; M01A8.2a.1; M01A8.2a.1; WBGene00010796. [P34531-1]
DR EnsemblMetazoa; M01A8.2b.1; M01A8.2b.1; WBGene00010796. [P34531-2]
DR GeneID; 176307; -.
DR KEGG; cel:CELE_M01A8.2; -.
DR UCSC; M01A8.2b; c. elegans. [P34531-1]
DR AGR; WB:WBGene00010796; -.
DR WormBase; M01A8.2a; CE33535; WBGene00010796; clip-1. [P34531-1]
DR WormBase; M01A8.2b; CE37262; WBGene00010796; clip-1. [P34531-2]
DR eggNOG; KOG4568; Eukaryota.
DR HOGENOM; CLU_296349_0_0_1; -.
DR InParanoid; P34531; -.
DR OMA; MSVPMVQ; -.
DR OrthoDB; 2882229at2759; -.
DR PRO; PR:P34531; -.
DR Proteomes; UP000001940; Chromosome III.
DR Bgee; WBGene00010796; Expressed in larva and 3 other cell types or tissues.
DR GO; GO:0030424; C:axon; IBA:GO_Central.
DR GO; GO:0000776; C:kinetochore; IBA:GO_Central.
DR GO; GO:0005875; C:microtubule associated complex; IBA:GO_Central.
DR GO; GO:0005635; C:nuclear envelope; IDA:WormBase.
DR GO; GO:0000922; C:spindle pole; IBA:GO_Central.
DR GO; GO:0008017; F:microtubule binding; IDA:WormBase.
DR GO; GO:0000132; P:establishment of mitotic spindle orientation; IBA:GO_Central.
DR GO; GO:0007097; P:nuclear migration; IBA:GO_Central.
DR GO; GO:0051647; P:nucleus localization; IMP:WormBase.
DR GO; GO:0006997; P:nucleus organization; IMP:WormBase.
DR Gene3D; 2.30.30.190; CAP Gly-rich-like domain; 1.
DR InterPro; IPR036859; CAP-Gly_dom_sf.
DR InterPro; IPR000938; CAP-Gly_domain.
DR PANTHER; PTHR18916:SF88; CAP-GLY DOMAIN-CONTAINING LINKER PROTEIN 1 HOMOLOG; 1.
DR PANTHER; PTHR18916; DYNACTIN 1-RELATED MICROTUBULE-BINDING; 1.
DR Pfam; PF01302; CAP_GLY; 1.
DR SMART; SM01052; CAP_GLY; 1.
DR SUPFAM; SSF74924; Cap-Gly domain; 1.
DR PROSITE; PS00845; CAP_GLY_1; 1.
DR PROSITE; PS50245; CAP_GLY_2; 1.
PE 4: Predicted;
KW Alternative splicing; Coiled coil; Reference proteome.
FT CHAIN 1..937
FT /note="CAP-Gly domain-containing linker protein 1 homolog"
FT /id="PRO_0000083545"
FT DOMAIN 39..81
FT /note="CAP-Gly"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00045"
FT REGION 90..131
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 264..548
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 819..866
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 916..937
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 566..740
FT /evidence="ECO:0000255"
FT COILED 773..800
FT /evidence="ECO:0000255"
FT COMPBIAS 264..284
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 296..318
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 319..355
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 382..396
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 423..443
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 445..475
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 486..506
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 514..533
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 534..548
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 819..855
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 916..930
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 103..170
FT /note="Missing (in isoform b)"
FT /evidence="ECO:0000305"
FT /id="VSP_016341"
SQ SEQUENCE 937 AA; 104728 MW; 4E3AF98810F184B6 CRC64;
MNKSHLGTAD NPQEVVTAHD IGRLVDVVNV GKGFLRYVGP IHGKDGMFCG IELLEPNGKH
DGTFQGVSYF IATPYHGIFA PIFRVTLDAE ELPKPPPPNP SNRLSRSALP ALQLRNPLTQ
ERKPEEDVMS TSVYVSSSTK PIAIPTKQCR PPETDPMQMS MFSDMMDGSM FSNGSWSDIA
DSMITSNCTF TVRKGLPIDD DGDLMSVPMV QSVFNIDREA LRREEQLQSS IVLGESRIGV
EHLPIIEDEN ELETPLVETR TMPLPNDLNA NFSNKNSTTT FVEPETPKVE IRENGNLDNS
IETPPQQSPS GSSMVSHESD SSSKKDDTKS DKSPTKKSQK MEEKPVVKKK EEPAAPPPPP
KFPVKQKAPS KHQLMMEQLK ASIEAEKTKP KKEIKSRVSL LPPPAPKAPQ KENKEGGEMT
ETPRRTITKT PLKTVNAKAK TSPTPPVERQ KKERKPLYVA PPAKERVEKE KKIPSKPVVS
PPTTAEKKPV VSSIPSTSSA SKGPFPTSSF AGGKLQGPRK TSSSSTTTSA KKQKNPPIDE
KEKLSRLQHS THAFEATLIV MNRINEDNER KLGNISEQYE KKVSELGDLK KMLDEARKKF
EEDVEQMKNS NQQVIRNHAN AVESLQKTHE TQIAEKNKEF ERNFEEERAR REAEVCAMNN
RHQKVVACLD EKISEAEKQC EQLNVDKKVL QAALANDCDH RNQMLTKEIS SLQTALEMKS
AEMKELRQKN QNLSLQVDEI PLKELEISKW KHKSNEYKQM LDQKINGEKI LVQQIEDLRR
KQIHDEEEKE AMKRSFDLMQ FKYENGDDPN VTSVMSAPME SRFSTPTKVQ FRSRSSASGS
RPISMATSNG GDQRLSTSSH HDDSMNRSTI SMYTSHIRLP ENHADDVIYA PDEIISSRSG
SISQRLAISI ENDGEPTIKS ESSRIGNTSD SGIGLVM
//
