ID   CLP1_DROAN              Reviewed;         425 AA.
AC   B3MGZ0;
DT   26-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   02-SEP-2008, sequence version 1.
DT   24-JAN-2024, entry version 65.
DE   RecName: Full=Protein CLP1 homolog {ECO:0000255|HAMAP-Rule:MF_03035};
GN   Name=cbc; ORFNames=GF11182;
OS   Drosophila ananassae (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7217;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 14024-0371.13;
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: Required for endonucleolytic cleavage during polyadenylation-
CC       dependent pre-mRNA 3'-end formation. {ECO:0000255|HAMAP-Rule:MF_03035}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|HAMAP-Rule:MF_03035}.
CC   -!- SIMILARITY: Belongs to the Clp1 family. Clp1 subfamily.
CC       {ECO:0000255|HAMAP-Rule:MF_03035}.
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DR   EMBL; CH902619; EDV37908.1; -; Genomic_DNA.
DR   RefSeq; XP_001961086.1; XM_001961050.2.
DR   AlphaFoldDB; B3MGZ0; -.
DR   SMR; B3MGZ0; -.
DR   STRING; 7217.B3MGZ0; -.
DR   EnsemblMetazoa; FBtr0115882; FBpp0114374; FBgn0088222.
DR   GeneID; 6494046; -.
DR   KEGG; dan:6494046; -.
DR   eggNOG; KOG2749; Eukaryota.
DR   HOGENOM; CLU_018195_1_0_1; -.
DR   InParanoid; B3MGZ0; -.
DR   OMA; VQYVNCH; -.
DR   OrthoDB; 56092at2759; -.
DR   PhylomeDB; B3MGZ0; -.
DR   Proteomes; UP000007801; Unassembled WGS sequence.
DR   GO; GO:0005849; C:mRNA cleavage factor complex; IEA:InterPro.
DR   GO; GO:0000214; C:tRNA-intron endonuclease complex; ISS:UniProtKB.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0051731; F:polynucleotide 5'-hydroxyl-kinase activity; IEA:InterPro.
DR   GO; GO:0031124; P:mRNA 3'-end processing; IEA:UniProtKB-UniRule.
DR   GO; GO:0043484; P:regulation of RNA splicing; IEA:EnsemblMetazoa.
DR   GO; GO:0006388; P:tRNA splicing, via endonucleolytic cleavage and ligation; ISS:UniProtKB.
DR   CDD; cd01983; SIMIBI; 1.
DR   Gene3D; 2.60.120.1030; Clp1, DNA binding domain; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 2.40.30.330; Pre-mRNA cleavage complex subunit Clp1, C-terminal domain; 1.
DR   HAMAP; MF_03035; Clp1; 1.
DR   InterPro; IPR028606; Clp1.
DR   InterPro; IPR045116; Clp1/Grc3.
DR   InterPro; IPR010655; Clp1_C.
DR   InterPro; IPR038238; Clp1_C_sf.
DR   InterPro; IPR032324; Clp1_N.
DR   InterPro; IPR038239; Clp1_N_sf.
DR   InterPro; IPR032319; CLP1_P.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR12755; CLEAVAGE/POLYADENYLATION FACTOR IA SUBUNIT CLP1P; 1.
DR   PANTHER; PTHR12755:SF6; POLYRIBONUCLEOTIDE 5'-HYDROXYL-KINASE CLP1; 1.
DR   Pfam; PF06807; Clp1; 1.
DR   Pfam; PF16573; CLP1_N; 1.
DR   Pfam; PF16575; CLP1_P; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE   3: Inferred from homology;
KW   ATP-binding; mRNA processing; Nucleotide-binding; Nucleus;
KW   Reference proteome.
FT   CHAIN           1..425
FT                   /note="Protein CLP1 homolog"
FT                   /id="PRO_0000375177"
FT   BINDING         18
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03035"
FT   BINDING         59
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03035"
FT   BINDING         121..126
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03035"
SQ   SEQUENCE   425 AA;  46939 MW;  0B71E7C6C93D65B3 CRC64;
     MSEELSHGKD YTLESDSELR FEIEQKDAKV LVTLISGFAE LFGTELVKKK KYEFGVGAKV
     AIFTYQGCVL HVSGKMDVCY ISKETPMVQY LNCHAALEQF RTDAEDKDQR GPVAMVVGPM
     DVGKSTLCRI LLNYAVRVGR RPLYADLDVG QGAIAISGNV ATILIERPAS VEDGFPKTAP
     LVYHFGHKSP GGNSVLYNSV VSKMAEVTLQ SLNSNKRTKS SGIIINTCGW VKGSGYAHLL
     HAAQAYGACA IFVLDQERLY NELLRDVPQG VNVVLLPKSG GVVERSKELR HESRDLRMKE
     YFYGNPRAPF YPFSFEVKFQ DLRLYKIGAP PLPDSCMPIG MKAEDNKTKV VAVTPTPALI
     HHILALSFAE SVEDDVIGSN VAGFCCVTEV DMERQAVMVL SPQPRPLPPN SLLLWSELQF
     MDNHT
//