ID CMC3_CAEBR Reviewed; 532 AA.
AC Q628Z2; A8WMD0;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 23-NOV-2004, sequence version 1.
DT 27-MAR-2024, entry version 98.
DE RecName: Full=Probable calcium-binding mitochondrial carrier CBG00135;
GN ORFNames=CBG00135;
OS Caenorhabditis briggsae.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6238;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AF16;
RX PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA Durbin R.M., Waterston R.H.;
RT "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT genomics.";
RL PLoS Biol. 1:166-192(2003).
CC -!- FUNCTION: Calcium-dependent mitochondrial solute carrier.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC {ECO:0000305}.
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DR EMBL; HE601409; CAP21634.1; -; Genomic_DNA.
DR RefSeq; XP_002645256.1; XM_002645210.1.
DR AlphaFoldDB; Q628Z2; -.
DR SMR; Q628Z2; -.
DR STRING; 6238.Q628Z2; -.
DR EnsemblMetazoa; CBG00135.1; CBG00135.1; WBGene00023609.
DR GeneID; 8587254; -.
DR KEGG; cbr:CBG_00135; -.
DR CTD; 8587254; -.
DR WormBase; CBG00135; CBP05663; WBGene00023609; -.
DR eggNOG; KOG0036; Eukaryota.
DR HOGENOM; CLU_015166_2_0_1; -.
DR InParanoid; Q628Z2; -.
DR OMA; VISYAEW; -.
DR OrthoDB; 1330359at2759; -.
DR Proteomes; UP000008549; Chromosome X.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005347; F:ATP transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0015866; P:ADP transport; IBA:GO_Central.
DR GO; GO:0015867; P:ATP transport; IBA:GO_Central.
DR Gene3D; 1.10.238.10; EF-hand; 2.
DR Gene3D; 1.50.40.10; Mitochondrial carrier domain; 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR002067; Mit_carrier.
DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR InterPro; IPR023395; Mt_carrier_dom_sf.
DR PANTHER; PTHR24089:SF57; FI05451P; 1.
DR PANTHER; PTHR24089; SOLUTE CARRIER FAMILY 25; 1.
DR Pfam; PF13499; EF-hand_7; 1.
DR Pfam; PF00153; Mito_carr; 3.
DR PRINTS; PR00926; MITOCARRIER.
DR SMART; SM00054; EFh; 3.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF103506; Mitochondrial carrier; 1.
DR PROSITE; PS00018; EF_HAND_1; 2.
DR PROSITE; PS50222; EF_HAND_2; 3.
DR PROSITE; PS50920; SOLCAR; 3.
PE 3: Inferred from homology;
KW Calcium; Membrane; Metal-binding; Mitochondrion;
KW Mitochondrion inner membrane; Reference proteome; Repeat; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..532
FT /note="Probable calcium-binding mitochondrial carrier
FT CBG00135"
FT /id="PRO_0000243923"
FT TRANSMEM 249..266
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TRANSMEM 304..323
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TRANSMEM 349..362
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TRANSMEM 400..419
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TRANSMEM 442..459
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TRANSMEM 501..518
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT DOMAIN 70..105
FT /note="EF-hand 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT DOMAIN 107..136
FT /note="EF-hand 2"
FT /evidence="ECO:0000305"
FT DOMAIN 137..172
FT /note="EF-hand 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT DOMAIN 173..208
FT /note="EF-hand 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT REPEAT 243..329
FT /note="Solcar 1"
FT REPEAT 339..425
FT /note="Solcar 2"
FT REPEAT 436..526
FT /note="Solcar 3"
FT BINDING 83
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 85
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 87
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 89
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 94
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 150
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 152
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 154
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 156
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 161
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
SQ SEQUENCE 532 AA; 59572 MW; E48D870AEBD6E85B CRC64;
MSVTVETPLQ AGPLLKEKKQ ELIDIKNIQE HARTVQPFKA SKHQPLISGS VSKEAAIATH
AALHIDLTPE KEKKIREMYD RLDADNDGSI DIRDLTQALS SQTPHIPATM APKLLAKMKR
EDSDRVTYAD FTNYVIAHEA RLAEVFDQID SNRDGEVDVS EIKSYCKEMG VNLDDHKALS
IVKKMDQSGS SSVNLNEFQD FMLLYPSTDM REMVDFWRHN LIIDIGEDGQ VPEDFTPQEL
QSGVWWRHLV AGGVAGAMSR TCTAPFDRIK VYLQVNSTKT NKLGVVSCVH LLHAEGGLKS
FWRGNGINVI KIAPESAMKF MSYDQIKRWI QEYKGGAELT TYERLFAGSS AGAISQTAIY
PMEVMKTRLA LRRTGQLDRG MIHFAHKMYD KEGIRCFYKG YLPNLLGIIP YAGIDLTVYE
TLKSCYTQYY TEHTEPGVLA LLACGTCSST CGQLASYPLA LVRTRLQARA ISPKNSSQPD
TMIGQFKHIL QNEGFTGLYR GITPNFMKVI PAVSISYVVY EKVRKQLGAT MS
//
