ID COE3_MOUSE Reviewed; 596 AA.
AC O08791; O08793;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1997, sequence version 1.
DT 24-JAN-2024, entry version 167.
DE RecName: Full=Transcription factor COE3;
DE AltName: Full=Early B-cell factor 3;
DE Short=EBF-3;
DE AltName: Full=Olf-1/EBF-like 2;
DE Short=O/E-2;
DE Short=OE-2;
GN Name=Ebf3; Synonyms=Coe3;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], ALTERNATIVE SPLICING, FUNCTION, AND SUBUNIT.
RC STRAIN=CD-1; TISSUE=Embryo;
RX PubMed=9151732; DOI=10.1523/jneurosci.17-11-04149.1997;
RA Wang S.S., Tsai R.Y.L., Reed R.R.;
RT "The characterization of the Olf-1/EBF-like HLH transcription factor
RT family: implications in olfactory gene regulation and neuronal
RT development.";
RL J. Neurosci. 17:4149-4158(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 58-229.
RC TISSUE=Embryonic head;
RX PubMed=9389446;
RX DOI=10.1002/(sici)1097-0177(199711)210:3<191::aid-aja1>3.0.co;2-b;
RA Garel S., Marin F., Mattei M.-G., Vesque C., Vincent A., Charnay P.;
RT "Family of Ebf/Olf-1-related genes potentially involved in neuronal
RT differentiation and regional specification in the central nervous system.";
RL Dev. Dyn. 210:191-205(1997).
CC -!- FUNCTION: Transcriptional activator (PubMed:9151732). Recognizes
CC variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3' (By
CC similarity). {ECO:0000250|UniProtKB:Q07802,
CC ECO:0000269|PubMed:9151732}.
CC -!- SUBUNIT: Forms either a homodimer or a heterodimer with a related
CC family member. {ECO:0000269|PubMed:9151732}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9H4W6}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=Long; Synonyms=9L;
CC IsoId=O08791-1; Sequence=Displayed;
CC Name=Short; Synonyms=0S;
CC IsoId=O08791-2; Sequence=VSP_001115, VSP_001116;
CC -!- TISSUE SPECIFICITY: Highly expressed in adult olfactory epithelium. In
CC embryo, expressed in epithalamus, hypothalamus, throughout the
CC brainstem and near the ventricular zones of mesencephalon, in rostral
CC rhombencephalon, in vomeronasal organ, at high level in developing
CC retina, developing spinal cord, at low level in dorsal root ganglia,
CC trigeminal ganglia, glossopharyngeal nerve ganglia. Not expressed in
CC developing inner eat.
CC -!- DEVELOPMENTAL STAGE: First detected at 9.5 dpc.
CC -!- SIMILARITY: Belongs to the COE family. {ECO:0000305}.
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DR EMBL; U92702; AAB58322.1; -; mRNA.
DR EMBL; U92704; AAB58324.1; -; mRNA.
DR EMBL; U82442; AAC64323.1; -; mRNA.
DR CCDS; CCDS21946.1; -. [O08791-2]
DR CCDS; CCDS52422.1; -. [O08791-1]
DR RefSeq; NP_001106886.1; NM_001113415.1. [O08791-1]
DR RefSeq; NP_034226.1; NM_010096.3. [O08791-2]
DR AlphaFoldDB; O08791; -.
DR SMR; O08791; -.
DR BioGRID; 199360; 2.
DR IntAct; O08791; 3.
DR MINT; O08791; -.
DR STRING; 10090.ENSMUSP00000147829; -.
DR iPTMnet; O08791; -.
DR PhosphoSitePlus; O08791; -.
DR MaxQB; O08791; -.
DR PaxDb; 10090-ENSMUSP00000101724; -.
DR PeptideAtlas; O08791; -.
DR ProteomicsDB; 285237; -. [O08791-1]
DR ProteomicsDB; 285238; -. [O08791-2]
DR Pumba; O08791; -.
DR Antibodypedia; 32510; 214 antibodies from 30 providers.
DR DNASU; 13593; -.
DR Ensembl; ENSMUST00000033378.13; ENSMUSP00000033378.6; ENSMUSG00000010476.15. [O08791-2]
DR Ensembl; ENSMUST00000210774.2; ENSMUSP00000147829.2; ENSMUSG00000010476.15. [O08791-1]
DR GeneID; 13593; -.
DR KEGG; mmu:13593; -.
DR UCSC; uc009ker.2; mouse. [O08791-2]
DR UCSC; uc012fvm.1; mouse. [O08791-1]
DR AGR; MGI:894289; -.
DR CTD; 253738; -.
DR MGI; MGI:894289; Ebf3.
DR VEuPathDB; HostDB:ENSMUSG00000010476; -.
DR eggNOG; KOG3836; Eukaryota.
DR GeneTree; ENSGT00950000182859; -.
DR HOGENOM; CLU_016320_3_1_1; -.
DR InParanoid; O08791; -.
DR OMA; NEAATPC; -.
DR OrthoDB; 3641706at2759; -.
DR PhylomeDB; O08791; -.
DR TreeFam; TF313391; -.
DR BioGRID-ORCS; 13593; 5 hits in 77 CRISPR screens.
DR ChiTaRS; Ebf3; mouse.
DR PRO; PR:O08791; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; O08791; Protein.
DR Bgee; ENSMUSG00000010476; Expressed in olfactory epithelium and 233 other cell types or tissues.
DR ExpressionAtlas; O08791; baseline and differential.
DR Genevisible; O08791; MM.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IDA:NTNU_SB.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IDA:NTNU_SB.
DR GO; GO:0045893; P:positive regulation of DNA-templated transcription; IDA:MGI.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:NTNU_SB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd11606; COE_DBD; 1.
DR CDD; cd01175; IPT_COE; 1.
DR Gene3D; 1.10.287.4280; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 2.60.40.3180; Transcription factor COE1, DNA-binding domain; 1.
DR InterPro; IPR032200; COE_DBD.
DR InterPro; IPR038173; COE_DBD_sf.
DR InterPro; IPR032201; COE_HLH.
DR InterPro; IPR038006; COE_IPT.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR002909; IPT_dom.
DR InterPro; IPR003523; Transcription_factor_COE.
DR InterPro; IPR018350; Transcription_factor_COE_CS.
DR PANTHER; PTHR10747; TRANSCRIPTION FACTOR COE FAMILY MEMBER; 1.
DR PANTHER; PTHR10747:SF4; TRANSCRIPTION FACTOR COE3; 1.
DR Pfam; PF16422; COE1_DBD; 1.
DR Pfam; PF16423; COE1_HLH; 1.
DR Pfam; PF01833; TIG; 1.
DR SMART; SM00429; IPT; 1.
DR SUPFAM; SSF81296; E set domains; 1.
DR PROSITE; PS01345; COE; 1.
PE 1: Evidence at protein level;
KW Activator; Alternative splicing; Developmental protein; DNA-binding;
KW Metal-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..596
FT /note="Transcription factor COE3"
FT /id="PRO_0000107833"
FT DOMAIN 263..346
FT /note="IPT/TIG"
FT ZN_FING 151..170
FT /note="C5-type"
FT /evidence="ECO:0000255"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 63..66
FT /note="Interaction with DNA"
FT /evidence="ECO:0000250"
FT REGION 197..204
FT /note="Interaction with DNA"
FT /evidence="ECO:0000250"
FT REGION 236..239
FT /note="Interaction with DNA"
FT /evidence="ECO:0000250"
FT REGION 451..483
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT SITE 163
FT /note="Interaction with DNA"
FT /evidence="ECO:0000250"
FT SITE 172
FT /note="Interaction with DNA"
FT /evidence="ECO:0000250"
FT VAR_SEQ 252..260
FT /note="Missing (in isoform Short)"
FT /evidence="ECO:0000305"
FT /id="VSP_001115"
FT VAR_SEQ 521..557
FT /note="IVPSSPTMAASSVTLPSNCSSTHGIFSFSPANVISAV -> M (in
FT isoform Short)"
FT /evidence="ECO:0000305"
FT /id="VSP_001116"
SQ SEQUENCE 596 AA; 64878 MW; 6934286C500F0ECE CRC64;
MFGIQENIPR GGTTMKEEPL GSGMNPVRSW MHTAGVVDAN TAAQSGVGLA RAHFEKQPPS
NLRKSNFFHF VLALYDRQGQ PVEIERTAFV DFVEKEKEPN NEKTNNGIHY KLQLLYSNGV
RTEQDLYVRL IDSMTKQAIV YEGQDKNPEM CRVLLTHEIM CSRCCDKKSC GNRNETPSDP
VIIDRFFLKF FLKCNQNCLK NAGNPRDMRR FQVVVSTTVN VDGHVLAVSD NMFVHNNSKH
GRRARRLDPS EGTAPSYLEN ATPCIKAISP SEGWTTGGAT VIIIGDNFFD GLQVVFGTML
VWSELITPHA IRVQTPPRHI PGVVEVTLSY KSKQFCKGAP GRFVYTALNE PTIDYGFQRL
QKVIPRHPGD PERLPKEVLL KRAADLVEAL YGMPHNNQEI ILKRAADIAE ALYSVPRNHN
QIPTLGNTPA HTGMMGVNSF SSQLAVNVSE TSQANDQVGY SRNTSSVSPR GYVPSSTPQQ
SNYNTVSTSM NGYGSGAMAN LGVPGSPGFL NGSSANSPYG IVPSSPTMAA SSVTLPSNCS
STHGIFSFSP ANVISAVKQK SAFAPVVRPQ ASPPPSCTSA NGNGLQAMSG LVVPPM
//
