ID COL6_CAEEL Reviewed; 329 AA.
AC P18831; Q23437;
DT 01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT 27-MAY-2002, sequence version 2.
DT 27-MAR-2024, entry version 160.
DE RecName: Full=Cuticle collagen 6;
DE AltName: Full=Protein roller-8;
GN Name=rol-8; Synonyms=col-6; ORFNames=ZK1290.3;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=2753356; DOI=10.1016/0378-1119(89)90173-x;
RA Cox G.N., Fields C., Kramer J.M., Rosenzweig B., Hirsh D.;
RT "Sequence comparisons of developmentally regulated collagen genes of
RT Caenorhabditis elegans.";
RL Gene 76:331-344(1989).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE SPLICING.
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: Nematode cuticles are composed largely of collagen-like
CC proteins. The cuticle functions both as an exoskeleton and as a barrier
CC to protect the worm from its environment.
CC -!- SUBUNIT: Collagen polypeptide chains are complexed within the cuticle
CC by disulfide bonds and other types of covalent cross-links.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=a;
CC IsoId=P18831-1; Sequence=Displayed;
CC Name=b;
CC IsoId=P18831-2; Sequence=VSP_001238;
CC -!- SIMILARITY: Belongs to the cuticular collagen family. {ECO:0000305}.
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DR EMBL; M25477; AAA27991.1; -; Genomic_DNA.
DR EMBL; FO080700; CCD65932.1; -; Genomic_DNA.
DR EMBL; FO080700; CCD65931.1; -; Genomic_DNA.
DR PIR; JS0167; JS0167.
DR PIR; T34507; T34507.
DR RefSeq; NP_495582.1; NM_063181.5. [P18831-1]
DR RefSeq; NP_871912.1; NM_182112.3.
DR AlphaFoldDB; P18831; -.
DR SMR; P18831; -.
DR BioGRID; 39560; 1.
DR STRING; 6239.ZK1290.3a.1; -.
DR EPD; P18831; -.
DR PaxDb; 6239-ZK1290-3a; -.
DR PeptideAtlas; P18831; -.
DR EnsemblMetazoa; ZK1290.3.1; ZK1290.3.1; WBGene00004398. [P18831-1]
DR GeneID; 174226; -.
DR KEGG; cel:CELE_ZK1290.3; -.
DR UCSC; ZK1290.3a; c. elegans. [P18831-1]
DR AGR; WB:WBGene00004398; -.
DR WormBase; ZK1290.3a; CE29156; WBGene00004398; rol-8. [P18831-1]
DR WormBase; ZK1290.3b; CE32085; WBGene00004398; rol-8. [P18831-2]
DR eggNOG; KOG3544; Eukaryota.
DR HOGENOM; CLU_001074_4_2_1; -.
DR InParanoid; P18831; -.
DR OMA; RDMWLEM; -.
DR OrthoDB; 2882978at2759; -.
DR PhylomeDB; P18831; -.
DR PRO; PR:P18831; -.
DR Proteomes; UP000001940; Chromosome II.
DR Bgee; WBGene00004398; Expressed in material anatomical entity and 3 other cell types or tissues.
DR GO; GO:0005581; C:collagen trimer; IEA:UniProtKB-KW.
DR GO; GO:0042302; F:structural constituent of cuticle; IEA:UniProtKB-KW.
DR GO; GO:0048856; P:anatomical structure development; IEA:UniProt.
DR InterPro; IPR002486; Col_cuticle_N.
DR InterPro; IPR008160; Collagen.
DR PANTHER; PTHR24637; COLLAGEN; 1.
DR PANTHER; PTHR24637:SF286; CUTICLE COLLAGEN 6; 1.
DR Pfam; PF01484; Col_cuticle_N; 1.
DR Pfam; PF01391; Collagen; 2.
DR SMART; SM01088; Col_cuticle_N; 1.
PE 3: Inferred from homology;
KW Alternative splicing; Collagen; Cuticle; Disulfide bond;
KW Reference proteome; Repeat.
FT CHAIN 1..329
FT /note="Cuticle collagen 6"
FT /id="PRO_0000127590"
FT REGION 142..171
FT /note="Triple-helical region"
FT REGION 146..329
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 189..212
FT /note="Triple-helical region"
FT REGION 216..248
FT /note="Triple-helical region"
FT REGION 253..279
FT /note="Triple-helical region"
FT REGION 282..320
FT /note="Triple-helical region"
FT COMPBIAS 196..210
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 254..290
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 197..261
FT /note="MGPKGPPGPKGSPGEPPQDGKSGDDGMAGQPGPIGRPGRDGMKGAPGAAGRL
FT IPVPGPQGAPGKP -> I (in isoform b)"
FT /evidence="ECO:0000305"
FT /id="VSP_001238"
FT CONFLICT 245
FT /note="A -> R (in Ref. 1; AAA27991)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 329 AA; 32476 MW; E1D0B6EF68322E97 CRC64;
MDVKETEEQR QMRRIAFVAV VVSTAAVIAS VVTLPMLYNY VQSFQSHLMV ETDYCKARSR
DMWLEMTALQ AGKGMGHRMK RAWLFGQWIP ETSAGGGGSG NGGGNYGSGA STGGGANTAG
YGGYGAAVNA EPAAVCCTCN QGAAGPPGPE GPPGNDGKDG RNGNDGKNGR DAEVLPAPAS
EPCIICPTGA PGPMGAMGPK GPPGPKGSPG EPPQDGKSGD DGMAGQPGPI GRPGRDGMKG
APGAAGRLIP VPGPQGAPGK PGPIGPPGPK GNPGPDGQSY QGPPGPPGDS GTPGHEGRAG
PNGPAGPPGD NGEKGDCGHC PPPRTPPGY
//
