ID COPZ_CAEEL Reviewed; 184 AA.
AC O17901;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 27-MAR-2024, entry version 133.
DE RecName: Full=Probable coatomer subunit zeta;
DE AltName: Full=Zeta-coat protein;
DE Short=Zeta-COP;
GN Name=copz-1 {ECO:0000312|WormBase:F59E10.3};
GN ORFNames=F59E10.3 {ECO:0000312|WormBase:F59E10.3};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: The coatomer is a cytosolic protein complex that binds to
CC dilysine motifs and reversibly associates with Golgi non-clathrin-
CC coated vesicles, which further mediate biosynthetic protein transport
CC from the ER, via the Golgi up to the trans Golgi network. Coatomer
CC complex is required for budding from Golgi membranes, and is essential
CC for the retrograde Golgi-to-ER transport of dilysine-tagged proteins
CC (By similarity). The zeta subunit may be involved in regulating the
CC coat assembly and, hence, the rate of biosynthetic protein transport
CC due to its association-dissociation properties with the coatomer
CC complex (By similarity). {ECO:0000250|UniProtKB:P53600}.
CC -!- SUBUNIT: Oligomeric complex that consists of at least the alpha, beta,
CC beta', gamma, delta, epsilon and zeta subunits.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Golgi apparatus membrane
CC {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic
CC side {ECO:0000250}. Cytoplasmic vesicle, COPI-coated vesicle membrane
CC {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic
CC side {ECO:0000250}. Note=The coatomer is cytoplasmic or polymerized on
CC the cytoplasmic side of the Golgi, as well as on the vesicles/buds
CC originating from it. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the adaptor complexes small subunit family.
CC {ECO:0000305}.
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DR EMBL; Z36949; CAA85416.1; -; Genomic_DNA.
DR PIR; T23002; T23002.
DR RefSeq; NP_496338.1; NM_063937.3.
DR AlphaFoldDB; O17901; -.
DR SMR; O17901; -.
DR BioGRID; 39985; 5.
DR STRING; 6239.F59E10.3.1; -.
DR EPD; O17901; -.
DR PaxDb; 6239-F59E10-3; -.
DR PeptideAtlas; O17901; -.
DR EnsemblMetazoa; F59E10.3.1; F59E10.3.1; WBGene00010333.
DR GeneID; 174675; -.
DR KEGG; cel:CELE_F59E10.3; -.
DR UCSC; F59E10.3; c. elegans.
DR AGR; WB:WBGene00010333; -.
DR WormBase; F59E10.3; CE11494; WBGene00010333; copz-1.
DR eggNOG; KOG3343; Eukaryota.
DR GeneTree; ENSGT00390000004405; -.
DR HOGENOM; CLU_086803_2_0_1; -.
DR InParanoid; O17901; -.
DR OMA; YDSHLAV; -.
DR OrthoDB; 7466at2759; -.
DR PhylomeDB; O17901; -.
DR Reactome; R-CEL-6807878; COPI-mediated anterograde transport.
DR Reactome; R-CEL-6811434; COPI-dependent Golgi-to-ER retrograde traffic.
DR PRO; PR:O17901; -.
DR Proteomes; UP000001940; Chromosome II.
DR Bgee; WBGene00010333; Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues.
DR GO; GO:0030126; C:COPI vesicle coat; ISS:UniProtKB.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0009792; P:embryo development ending in birth or egg hatching; IMP:WormBase.
DR GO; GO:0006891; P:intra-Golgi vesicle-mediated transport; ISS:UniProtKB.
DR GO; GO:0006886; P:intracellular protein transport; IMP:WormBase.
DR GO; GO:0048599; P:oocyte development; IMP:WormBase.
DR GO; GO:0006890; P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum; IBA:GO_Central.
DR CDD; cd14829; Zeta-COP; 1.
DR Gene3D; 3.30.450.60; -; 1.
DR InterPro; IPR022775; AP_mu_sigma_su.
DR InterPro; IPR000804; Clathrin_sm-chain_CS.
DR InterPro; IPR039652; Coatomer_zeta.
DR InterPro; IPR011012; Longin-like_dom_sf.
DR PANTHER; PTHR11043:SF0; COATOMER SUBUNIT ZETA; 1.
DR PANTHER; PTHR11043; ZETA-COAT PROTEIN; 1.
DR Pfam; PF01217; Clat_adaptor_s; 1.
DR SUPFAM; SSF64356; SNARE-like; 1.
DR PROSITE; PS00989; CLAT_ADAPTOR_S; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Cytoplasmic vesicle; ER-Golgi transport; Golgi apparatus;
KW Membrane; Protein transport; Reference proteome; Transport.
FT CHAIN 1..184
FT /note="Probable coatomer subunit zeta"
FT /id="PRO_0000193828"
SQ SEQUENCE 184 AA; 20757 MW; 9E33FFDAD38288DD CRC64;
MADFDTNPTS LYSIKGIVIL DQDGNRVLAK YYDRTTFGTV KEQKAFEKSL FSKTSRNTSA
DILLLDGVTC LYRSNVDLYF YVLGSTRENE LFLDATLTCL YDAVSVVLRK NVEKKALIDS
MDTIMLIIDE ICDEGIIMET DAQAVVQRTA LKSDEVSFSD QSVSQIGFSF MKSANEQFKW
SLLK
//
