ID CPND_DICDI Reviewed; 530 AA.
AC Q55GG1;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 27-MAR-2024, entry version 93.
DE RecName: Full=Copine-D;
GN Name=cpnD; ORFNames=DDB_G0267688;
OS Dictyostelium discoideum (Social amoeba).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [2]
RP DEVELOPMENTAL STAGE.
RX PubMed=17259548; DOI=10.1128/ec.00322-06;
RA Damer C.K., Bayeva M., Kim P.S., Ho L.K., Eberhardt E.S., Socec C.I.,
RA Lee J.S., Bruce E.A., Goldman-Yassen A.E., Naliboff L.C.;
RT "Copine A is required for cytokinesis, contractile vacuole function, and
RT development in Dictyostelium.";
RL Eukaryot. Cell 6:430-442(2007).
CC -!- COFACTOR:
CC Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC Evidence={ECO:0000255|PROSITE-ProRule:PRU00041};
CC -!- DEVELOPMENTAL STAGE: Expressed at relatively high levels in vegetative
CC cells. The expression goes down until the 8th hour of development and
CC then goes up at 14 to 16 hours. {ECO:0000269|PubMed:17259548}.
CC -!- SIMILARITY: Belongs to the copine family. {ECO:0000305}.
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DR EMBL; AAFI02000003; EAL73297.1; -; Genomic_DNA.
DR RefSeq; XP_647223.1; XM_642131.1.
DR AlphaFoldDB; Q55GG1; -.
DR SMR; Q55GG1; -.
DR STRING; 44689.Q55GG1; -.
DR PaxDb; 44689-DDB0216244; -.
DR EnsemblProtists; EAL73297; EAL73297; DDB_G0267688.
DR GeneID; 8616027; -.
DR KEGG; ddi:DDB_G0267688; -.
DR dictyBase; DDB_G0267688; cpnD.
DR eggNOG; KOG1327; Eukaryota.
DR HOGENOM; CLU_020452_3_2_1; -.
DR InParanoid; Q55GG1; -.
DR OMA; CHKTEYV; -.
DR PhylomeDB; Q55GG1; -.
DR Reactome; R-DDI-1483206; Glycerophospholipid biosynthesis.
DR Reactome; R-DDI-6798695; Neutrophil degranulation.
DR PRO; PR:Q55GG1; -.
DR Proteomes; UP000002195; Chromosome 1.
DR GO; GO:0005829; C:cytosol; IEA:UniProt.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005544; F:calcium-dependent phospholipid binding; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0071277; P:cellular response to calcium ion; IBA:GO_Central.
DR CDD; cd04048; C2A_Copine; 1.
DR CDD; cd04047; C2B_Copine; 1.
DR Gene3D; 2.60.40.150; C2 domain; 2.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR037768; C2B_Copine.
DR InterPro; IPR045052; Copine.
DR InterPro; IPR010734; Copine_C.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR10857; COPINE; 1.
DR PANTHER; PTHR10857:SF106; NICOTINIC RECEPTOR-ASSOCIATED PROTEIN 1; 1.
DR Pfam; PF00168; C2; 2.
DR Pfam; PF07002; Copine; 1.
DR SMART; SM00239; C2; 2.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 2.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS50004; C2; 2.
DR PROSITE; PS50234; VWFA; 1.
PE 2: Evidence at transcript level;
KW Calcium; Metal-binding; Reference proteome; Repeat.
FT CHAIN 1..530
FT /note="Copine-D"
FT /id="PRO_0000330657"
FT DOMAIN 1..122
FT /note="C2 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT DOMAIN 130..248
FT /note="C2 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT DOMAIN 289..507
FT /note="VWFA"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00219"
FT BINDING 25
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT BINDING 25
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT BINDING 31
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT BINDING 85
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT BINDING 85
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT BINDING 87
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT BINDING 87
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT BINDING 100
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
SQ SEQUENCE 530 AA; 59429 MW; B81ABDABF9E49749 CRC64;
MNPIQPIPKS KIEIRIKCKD LTSKDLLSQS DPQAIVYLKQ QQRNDWIQQG KTEKLKNQKS
PEFKQSITVD YHFEEVQLLK IVVIDIDKDI KLLKDFDDHD LIGEVNVSLG SILSSPGGRM
KMSLTKNGIL SGSITISTEE IRETGANIYF ALEGNHLDKK DLLSSDPYFK IYKSGGTLVY
QSDVIKNTLN PTFPPVYLKL EELNGGDMFR ELTFEFMDWD KIGDHDLIGR FTTNTDTILR
GGALEFEIIN PKKVGKSGYK NSGIIKFYIA RIQGDPTFLD YLHGGLEINL MVAIDCTASN
MPPDVSTSLH YNTPTQPSQY ASSIAAVGNV LAPYDYDQMI EVVGFGGLYN GHTSHCFPFN
LTNGDDNKSE AHGLQEVLDI YYNNVLKIPF SYPTNFENVI HHAIKRASKS TQSNQKYTVL
LIITDGDISD TQKTIDELVS ASKSALSVVI IGVGNYHFEA MKILDGDEKG LVDSKGNPSK
RDICQFVPFN DFKNYPEALA HETLKEIPSQ VLSFMKLSKI HPNQPRQFNC
//
