ID CSM3_CANAL Reviewed; 316 AA.
AC Q59X26; A0A1D8PHK5;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 26-APR-2005, sequence version 1.
DT 27-MAR-2024, entry version 81.
DE RecName: Full=Chromosome segregation in meiosis protein 3;
GN Name=CSM3; OrderedLocusNames=CAALFM_C206130WA;
GN ORFNames=CaO19.11586, CaO19.4105;
OS Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=237561;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA Scherer S.;
RT "The diploid genome sequence of Candida albicans.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA Chibana H., Nantel A., Magee P.T.;
RT "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT on the eight chromosomes.";
RL Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT specific measurements and provides a simple model for repeat and indel
RT structure.";
RL Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC -!- FUNCTION: Forms a fork protection complex (FPC) with TOF1 and which is
CC required for chromosome segregation during meiosis and DNA damage
CC repair. FPC coordinates leading and lagging strand synthesis and moves
CC with the replication fork. FPC stabilizes replication forks in a
CC configuration that is recognized by replication checkpoint sensors (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: Component of the fork protection complex (FPC) consisting of
CC TOF1 and CSM3. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the CSM3 family. {ECO:0000305}.
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DR EMBL; CP017624; AOW27621.1; -; Genomic_DNA.
DR RefSeq; XP_714276.1; XM_709183.1.
DR AlphaFoldDB; Q59X26; -.
DR SMR; Q59X26; -.
DR STRING; 237561.Q59X26; -.
DR EnsemblFungi; C2_06130W_A-T; C2_06130W_A-T-p1; C2_06130W_A.
DR GeneID; 3644083; -.
DR KEGG; cal:CAALFM_C206130WA; -.
DR CGD; CAL0000183710; CSM3.
DR VEuPathDB; FungiDB:C2_06130W_A; -.
DR eggNOG; KOG3004; Eukaryota.
DR HOGENOM; CLU_068092_0_0_1; -.
DR InParanoid; Q59X26; -.
DR OMA; ADMDDMW; -.
DR OrthoDB; 1388129at2759; -.
DR PRO; PR:Q59X26; -.
DR Proteomes; UP000000559; Chromosome 2.
DR GO; GO:0031298; C:replication fork protection complex; IBA:GO_Central.
DR GO; GO:0003677; F:DNA binding; IBA:GO_Central.
DR GO; GO:0006974; P:DNA damage response; IGI:CGD.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR GO; GO:0000076; P:DNA replication checkpoint signaling; IBA:GO_Central.
DR GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0043111; P:replication fork arrest; IBA:GO_Central.
DR GO; GO:0031297; P:replication fork processing; IEA:InterPro.
DR InterPro; IPR012923; Csm3.
DR InterPro; IPR040038; TIPIN/Csm3/Swi3.
DR PANTHER; PTHR13220; TIMELESS INTERACTING-RELATED; 1.
DR PANTHER; PTHR13220:SF11; TIMELESS-INTERACTING PROTEIN; 1.
DR Pfam; PF07962; Swi3; 1.
PE 3: Inferred from homology;
KW Cell cycle; DNA damage; DNA repair; DNA replication inhibitor; Meiosis;
KW Nucleus; Reference proteome.
FT CHAIN 1..316
FT /note="Chromosome segregation in meiosis protein 3"
FT /id="PRO_0000301714"
FT REGION 1..42
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 176..195
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 236..316
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 12..26
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 316 AA; 35689 MW; 737A839DDD257765 CRC64;
MSYVMDETEE GINIDNTQHD LELDRDSSTQ QPAQTHEDDG DLLGLDKPIK LKTRAKIAKV
DNQRIFNHNG IPLLVKTHSK LLRTLKKNDK NFYSEPRSSI SKSQKFEHEY ENLSSVLQFY
QLWCHGLFPK ATFKDCIHLI RALGARSPQL RLYRRELIAA ELHKLKVAKG IIADENQDAP
SIPEEENTTD PSNEEWNSMH MSALVPGSSN KNGLFVDSNS NEDFETTNEV NAAASLADKD
ALSTDDKAEQ TNAITSDTHN NDVDSDDPFS DDDDINIDAH TENLHPASGT QHQDRPKETT
EENEDLELEL MREYGA
//
