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Database: UniProt
Entry: CWC24_NEUCR
LinkDB: CWC24_NEUCR
Original site: CWC24_NEUCR 
ID   CWC24_NEUCR             Reviewed;         405 AA.
AC   Q7SDY3;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-DEC-2003, sequence version 1.
DT   08-MAY-2019, entry version 97.
DE   RecName: Full=Pre-mRNA-splicing factor cwc-24;
GN   Name=cwc-24; ORFNames=NCU01954;
OS   Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM
OS   1257 / FGSC 987).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
OC   Sordariomycetes; Sordariomycetidae; Sordariales; Sordariaceae;
OC   Neurospora.
OX   NCBI_TaxID=367110;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12712197; DOI=10.1038/nature01554;
RA   Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA   Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA   Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA   Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A.,
RA   Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L.,
RA   Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C.,
RA   Marcotte E., Greenberg D., Roy A., Foley K., Naylor J.,
RA   Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M.,
RA   Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S.,
RA   Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C.,
RA   Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA   DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA   Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA   Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M.,
RA   Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT   "The genome sequence of the filamentous fungus Neurospora crassa.";
RL   Nature 422:859-868(2003).
CC   -!- FUNCTION: Involved in pre-mRNA splicing. {ECO:0000250}.
CC   -!- SUBUNIT: Associated with the spliceosome. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CWC24 family. {ECO:0000305}.
DR   EMBL; CM002236; EAA35002.1; -; Genomic_DNA.
DR   RefSeq; XP_964238.1; XM_959145.2.
DR   SMR; Q7SDY3; -.
DR   PRIDE; Q7SDY3; -.
DR   EnsemblFungi; EAA35002; EAA35002; NCU01954.
DR   GeneID; 3880387; -.
DR   KEGG; ncr:NCU01954; -.
DR   EuPathDB; FungiDB:NCU01954; -.
DR   HOGENOM; HOG000174759; -.
DR   InParanoid; Q7SDY3; -.
DR   KO; K13127; -.
DR   Proteomes; UP000001805; Chromosome 1, Linkage Group I.
DR   GO; GO:0005684; C:U2-type spliceosomal complex; IBA:GO_Central.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:0034247; P:snoRNA splicing; IBA:GO_Central.
DR   Gene3D; 3.30.40.10; -; 1.
DR   InterPro; IPR039971; CWC24-like.
DR   InterPro; IPR000571; Znf_CCCH.
DR   InterPro; IPR036855; Znf_CCCH_sf.
DR   InterPro; IPR001841; Znf_RING.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   InterPro; IPR017907; Znf_RING_CS.
DR   PANTHER; PTHR12930; PTHR12930; 1.
DR   Pfam; PF00642; zf-CCCH; 1.
DR   Pfam; PF14634; zf-RING_5; 1.
DR   SMART; SM00184; RING; 1.
DR   SMART; SM00356; ZnF_C3H1; 1.
DR   SUPFAM; SSF90229; SSF90229; 1.
DR   PROSITE; PS50103; ZF_C3H1; 1.
DR   PROSITE; PS00518; ZF_RING_1; 1.
DR   PROSITE; PS50089; ZF_RING_2; 1.
PE   3: Inferred from homology;
KW   Complete proteome; DNA-binding; Metal-binding; mRNA processing;
KW   mRNA splicing; Nucleus; Reference proteome; Spliceosome; Zinc;
KW   Zinc-finger.
FT   CHAIN         1    405       Pre-mRNA-splicing factor cwc-24.
FT                                /FTId=PRO_0000055891.
FT   ZN_FING     221    249       C3H1-type. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00723}.
FT   ZN_FING     310    349       RING-type. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00175}.
FT   COMPBIAS    374    402       Glu-rich.
SQ   SEQUENCE   405 AA;  44440 MW;  89817695377ECF75 CRC64;
     MADTEQPPTA PTAPEPTTAT PTAPIAPVAI FKKRGAKGKA NLRKRPASPP PAAKDSDDDS
     SDFESSEDEA TGQRIKRRKK NHHSAAVMAS SRDHNASTNS GVTKEEQIRS NTIYEADRDA
     ALRLDATKQD ATKGSNWFDE DNEKEDLSVG NLLGRTRTMM KTKKKVGGED DAVQNSEREP
     DGTYRGLANQ ASYIQKNPNA PNRKVGPIKA PSNIRTITIT DMAPDVCKDY KQTGFCGFGD
     NCKFLHARED YAHGWQLDKE WENVTKGKKN LQGTVVASAD RRNKPKNTAE EEEDADAAEE
     ALLENIPFAC IICRGPYSNS PVVTRCGHYF CEACALKRYR KDPSCAACGS GTNGVFNAAK
     RLAKLLEKKK ARAERLRREA RERGEEVSEE EDEGEDEGEG AEGSD
//
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